node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMT2 | CUNH12orf66 | A0A341CI46 | A0A341ASS4 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | KICSTOR complex protein C12orf66 homolog. | 0.901 |
BMT2 | ITFG2 | A0A341CI46 | A0A341AH00 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | KICSTOR complex protein ITFG2. | 0.880 |
BMT2 | KPTN | A0A341CI46 | A0A341DBX9 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | KICSTOR complex protein kaptin. | 0.869 |
BMT2 | SZT2 | A0A341CI46 | A0A341BFP5 | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | KICSTOR complex protein SZT2 isoform X1. | 0.839 |
CUNH12orf66 | BMT2 | A0A341ASS4 | A0A341CI46 | KICSTOR complex protein C12orf66 homolog. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.901 |
CUNH12orf66 | ITFG2 | A0A341ASS4 | A0A341AH00 | KICSTOR complex protein C12orf66 homolog. | KICSTOR complex protein ITFG2. | 0.998 |
CUNH12orf66 | KPTN | A0A341ASS4 | A0A341DBX9 | KICSTOR complex protein C12orf66 homolog. | KICSTOR complex protein kaptin. | 0.998 |
CUNH12orf66 | SZT2 | A0A341ASS4 | A0A341BFP5 | KICSTOR complex protein C12orf66 homolog. | KICSTOR complex protein SZT2 isoform X1. | 0.993 |
ITFG2 | BMT2 | A0A341AH00 | A0A341CI46 | KICSTOR complex protein ITFG2. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.880 |
ITFG2 | CUNH12orf66 | A0A341AH00 | A0A341ASS4 | KICSTOR complex protein ITFG2. | KICSTOR complex protein C12orf66 homolog. | 0.998 |
ITFG2 | KPTN | A0A341AH00 | A0A341DBX9 | KICSTOR complex protein ITFG2. | KICSTOR complex protein kaptin. | 0.999 |
ITFG2 | SZT2 | A0A341AH00 | A0A341BFP5 | KICSTOR complex protein ITFG2. | KICSTOR complex protein SZT2 isoform X1. | 0.993 |
KPTN | BMT2 | A0A341DBX9 | A0A341CI46 | KICSTOR complex protein kaptin. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.869 |
KPTN | CUNH12orf66 | A0A341DBX9 | A0A341ASS4 | KICSTOR complex protein kaptin. | KICSTOR complex protein C12orf66 homolog. | 0.998 |
KPTN | ITFG2 | A0A341DBX9 | A0A341AH00 | KICSTOR complex protein kaptin. | KICSTOR complex protein ITFG2. | 0.999 |
KPTN | SZT2 | A0A341DBX9 | A0A341BFP5 | KICSTOR complex protein kaptin. | KICSTOR complex protein SZT2 isoform X1. | 0.994 |
SZT2 | BMT2 | A0A341BFP5 | A0A341CI46 | KICSTOR complex protein SZT2 isoform X1. | S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] | 0.839 |
SZT2 | CUNH12orf66 | A0A341BFP5 | A0A341ASS4 | KICSTOR complex protein SZT2 isoform X1. | KICSTOR complex protein C12orf66 homolog. | 0.993 |
SZT2 | ITFG2 | A0A341BFP5 | A0A341AH00 | KICSTOR complex protein SZT2 isoform X1. | KICSTOR complex protein ITFG2. | 0.993 |
SZT2 | KPTN | A0A341BFP5 | A0A341DBX9 | KICSTOR complex protein SZT2 isoform X1. | KICSTOR complex protein kaptin. | 0.994 |