(62 nodes) Ribonuclease H-like superfamily network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIWIL4	Piwi-like protein 4; Belongs to the argonaute family. (852 aa)
	ISG20	Interferon-stimulated gene 20 kDa protein. (171 aa)
	AEN	Apoptosis-enhancing nuclease. (316 aa)
	EXD1	piRNA biogenesis protein EXD1 isoform X1. (588 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
	ESRP2	Epithelial splicing regulatory protein 2 isoform X1. (767 aa)
	PRPF8	pre-mRNA-processing-splicing factor 8. (2335 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa)
	ZBED4	Zinc finger BED domain-containing protein 4. (1174 aa)
	TEFM	Transcription elongation factor, mitochondrial. (360 aa)
	AGO1	Protein argonaute-1 isoform X1; Belongs to the argonaute family. (860 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	EXD2	Exonuclease 3'-5' domain-containing protein 2. (623 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (794 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2279 aa)
	GIN1	Gypsy retrotransposon integrase-like protein 1 isoform X1. (528 aa)
	REV3L	DNA polymerase zeta catalytic subunit. (3133 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (865 aa)
	REXO1	RNA exonuclease 1 homolog. (1284 aa)
	ZMYM1	Zinc finger MYM-type protein 1 isoform X1. (1146 aa)
	ZMYM6	Zinc finger MYM-type protein 6 isoform X1. (1347 aa)
	PIWIL3	LOW QUALITY PROTEIN: piwi-like protein 3; Belongs to the argonaute family. (672 aa)
	ERI2	ERI1 exoribonuclease 2 isoform X1. (710 aa)
	REXO5	RNA exonuclease 5. (772 aa)
	PARN	poly(A)-specific ribonuclease PARN isoform X1. (638 aa)
	TOE1	Target of EGR1 protein 1 isoform X1. (510 aa)
	FAM200A	LOW QUALITY PROTEIN: protein FAM200A. (576 aa)
	POLA1	DNA polymerase. (1468 aa)
	LOC112401115	General transcription factor II-I repeat domain-containing protein 2. (948 aa)
	PIWIL2	Piwi-like protein 2 isoform X1; Belongs to the argonaute family. (971 aa)
	KRBA2	KRAB-A domain-containing protein 2. (411 aa)
	PNLDC1	poly(A)-specific ribonuclease PNLDC1. (531 aa)
	ISG20L2	Interferon-stimulated 20 kDa exonuclease-like 2 isoform X1. (348 aa)
	EXOSC10	Exosome component 10 isoform X1. (957 aa)
	REXO2	Oligoribonuclease, mitochondrial. (237 aa)
	TREX1	Three-prime repair exonuclease 1. (314 aa)
	NYNRIN	Protein NYNRIN. (1882 aa)
	SRBD1	S1 RNA-binding domain-containing protein 1 isoform X1. (1011 aa)
	ZNF862	Zinc finger protein 862 isoform X1. (1171 aa)
	ZBED6CL	LOW QUALITY PROTEIN: ZBED6 C-terminal-like protein. (327 aa)
	LOC112405917	Uncharacterized protein LOC112405917 isoform X2. (584 aa)
	TREX2	LOW QUALITY PROTEIN: three prime repair exonuclease 2. (218 aa)
	ZBED1	Zinc finger BED domain-containing protein 1. (703 aa)
	RNASEH1	Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (287 aa)
	ZBED5	Zinc finger BED domain-containing protein 5. (694 aa)
	PIWIL1	Piwi-like protein 1; Belongs to the argonaute family. (861 aa)
	LOC112408989	LOW QUALITY PROTEIN: uncharacterized protein LOC112408989. (714 aa)
	ERI3	ERI1 exoribonuclease 3 isoform X1. (337 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8 isoform X1. (349 aa)
	LOC112410995	Uncharacterized protein LOC112410995. (375 aa)
	EXD3	Exonuclease mut-7 homolog isoform X1. (930 aa)
	ZNF618	Zinc finger protein 618 isoform X1. (900 aa)
	REXO4	LOW QUALITY PROTEIN: RNA exonuclease 4. (595 aa)
	ZBED9	SCAN domain-containing protein 3. (1326 aa)
	ERI1	3'-5' exoribonuclease 1 isoform X1. (349 aa)
	WRN	Werner syndrome ATP-dependent helicase isoform X1. (1445 aa)
	ESRP1	Epithelial splicing regulatory protein 1 isoform X6. (681 aa)
	POLG	LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1. (1227 aa)
	RNASEH2A	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (297 aa)
	POLD1	DNA polymerase. (1107 aa)
	POLQ	DNA polymerase theta. (2597 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEN	EXOSC10	A0A341ADJ8	A0A341BSM3	Apoptosis-enhancing nuclease.	Exosome component 10 isoform X1.	0.556
AEN	REXO2	A0A341ADJ8	A0A341BYA0	Apoptosis-enhancing nuclease.	Oligoribonuclease, mitochondrial.	0.522
AGO1	AGO2	A0A341AVI2	A0A341B1R1	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.984
AGO1	AGO3	A0A341AVI2	A0A341AVN4	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.634
AGO1	AGO4	A0A341AVI2	A0A341AYB2	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.979
AGO1	ERI3	A0A341AVI2	A0A341CN03	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	ERI1 exoribonuclease 3 isoform X1.	0.422
AGO2	AGO1	A0A341B1R1	A0A341AVI2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.984
AGO2	AGO3	A0A341B1R1	A0A341AVN4	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.963
AGO2	AGO4	A0A341B1R1	A0A341AYB2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.929
AGO2	CNOT7	A0A341B1R1	A0A341CN18	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 7.	0.572
AGO3	AGO1	A0A341AVN4	A0A341AVI2	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.634
AGO3	AGO2	A0A341AVN4	A0A341B1R1	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.963
AGO3	AGO4	A0A341AVN4	A0A341AYB2	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.574
AGO4	AGO1	A0A341AYB2	A0A341AVI2	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-1 isoform X1; Belongs to the argonaute family.	0.979
AGO4	AGO2	A0A341AYB2	A0A341B1R1	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.929
AGO4	AGO3	A0A341AYB2	A0A341AVN4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.574
CNOT7	AGO2	A0A341CN18	A0A341B1R1	CCR4-NOT transcription complex subunit 7.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.572
CNOT7	CNOT8	A0A341CN18	A0A341CND0	CCR4-NOT transcription complex subunit 7.	CCR4-NOT transcription complex subunit 8 isoform X1.	0.961
CNOT7	PAN2	A0A341CN18	A0A341APW7	CCR4-NOT transcription complex subunit 7.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.410
CNOT7	PARN	A0A341CN18	A0A341BDN6	CCR4-NOT transcription complex subunit 7.	poly(A)-specific ribonuclease PARN isoform X1.	0.526