(59 nodes) FAD/NAD(P)-binding domain superfamily network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	GPD2	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (727 aa)
	MTO1	Protein MTO1 homolog, mitochondrial. (674 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (665 aa)
	TXNRD1	Thioredoxin reductase 1, cytoplasmic. (497 aa)
	MICAL3	LOW QUALITY PROTEIN: F-actin-monooxygenase MICAL3. (1962 aa)
	GDI2	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (218 aa)
	CHML	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (651 aa)
	MAOB	Amine oxidase. (520 aa)
	PYROXD1	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 isoform X1. (502 aa)
	PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1. (878 aa)
	MAOA	Amine oxidase. (527 aa)
	HPS1	Hermansky-Pudlak syndrome 1 protein isoform X1. (906 aa)
	OSGIN1	Oxidative stress-induced growth inhibitor 1. (478 aa)
	PIPOX	Peroxisomal sarcosine oxidase. (390 aa)
	PCYOX1L	Prenylcysteine oxidase-like. (492 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (475 aa)
	LOC112396202	Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
	FMO2	Dimethylaniline monooxygenase [N-oxide-forming]. (537 aa)
	FMO3	Flavin-containing monooxygenase. (281 aa)
	FMO1	Dimethylaniline monooxygenase [N-oxide-forming]. (539 aa)
	SQLE	Squalene monooxygenase. (574 aa)
	FMO4	Dimethylaniline monooxygenase [N-oxide-forming]. (577 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (493 aa)
	FOXRED1	FAD-dependent oxidoreductase domain-containing protein 1 isoform X1. (527 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	SMOX	Spermine oxidase isoform X1. (585 aa)
	RETSAT	All-trans-retinol 13,14-reductase. (609 aa)
	LOC112399533	Amine oxidase. (529 aa)
	RNLS	Renalase. (443 aa)
	ETFDH	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
	GDI1	Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (417 aa)
	CHDH	Choline dehydrogenase. (594 aa)
	DPYD	Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family. (1025 aa)
	CFAP61	Cilia- and flagella-associated protein 61. (1237 aa)
	MICAL1	F-actin-monooxygenase MICAL1 isoform X1. (1067 aa)
	DMGDH	Dimethylglycine dehydrogenase, mitochondrial isoform X1. (866 aa)
	OSGIN2	Oxidative stress-induced growth inhibitor 2 isoform X1. (551 aa)
	PCYOX1	Prenylcysteine oxidase 1. (526 aa)
	KDM1B	Lysine-specific histone demethylase 1B isoform X1. (820 aa)
	PPOX	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (478 aa)
	LOC112407716	F-actin-monooxygenase MICAL2 isoform X1. (1722 aa)
	AIFM1	Apoptosis-inducing factor 1, mitochondrial. (613 aa)
	LOC112409775	Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. (521 aa)
	FDXR	NADPH:adrenodoxin oxidoreductase, mitochondrial isoform X1. (549 aa)
	SQOR	Sulfide:quinone oxidoreductase, mitochondrial isoform X1. (450 aa)
	FOXRED2	FAD-dependent oxidoreductase domain-containing protein 2 isoform X1. (687 aa)
	PAOX	Peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform X1. (436 aa)
	SARDH	Sarcosine dehydrogenase, mitochondrial. (918 aa)
	TXNRD3	Thioredoxin reductase 3 isoform X1. (580 aa)
	TXNRD2	Thioredoxin reductase 2, mitochondrial isoform X1. (566 aa)
	LOC112412216	Leucine-zipper-like transcriptional regulator 1 isoform X6. (1359 aa)
	LOC112413003	Flavin-containing monooxygenase. (394 aa)
	GSR	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (492 aa)
	AIFM2	Apoptosis-inducing factor 2 isoform X1. (373 aa)
	LOC112413035	Flavin-containing monooxygenase. (382 aa)
	LOC112413465	Rab GDP dissociation inhibitor beta-like. (196 aa)
	L2HGDH	L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1. (463 aa)
	KDM1A	Lysine-specific histone demethylase 1A. (730 aa)
	IL4I1	L-amino-acid oxidase. (588 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIFM1	DLD	A0A341CIX5	A0A341B581	Apoptosis-inducing factor 1, mitochondrial.	Dihydrolipoyl dehydrogenase.	0.576
AIFM1	DMGDH	A0A341CIX5	A0A341C9M7	Apoptosis-inducing factor 1, mitochondrial.	Dimethylglycine dehydrogenase, mitochondrial isoform X1.	0.439
AIFM1	GSR	A0A341CIX5	A0A341D267	Apoptosis-inducing factor 1, mitochondrial.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.662
AIFM1	L2HGDH	A0A341CIX5	A0A341D6S2	Apoptosis-inducing factor 1, mitochondrial.	L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1.	0.539
AIFM1	PDPR	A0A341CIX5	A0A341AKU4	Apoptosis-inducing factor 1, mitochondrial.	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1.	0.441
AIFM1	PIPOX	A0A341CIX5	A0A341AR56	Apoptosis-inducing factor 1, mitochondrial.	Peroxisomal sarcosine oxidase.	0.771
AIFM1	SARDH	A0A341CIX5	A0A341CTU1	Apoptosis-inducing factor 1, mitochondrial.	Sarcosine dehydrogenase, mitochondrial.	0.439
AIFM1	TXNRD1	A0A341CIX5	A0A341AB81	Apoptosis-inducing factor 1, mitochondrial.	Thioredoxin reductase 1, cytoplasmic.	0.536
AIFM1	TXNRD2	A0A341CIX5	A0A341CXT6	Apoptosis-inducing factor 1, mitochondrial.	Thioredoxin reductase 2, mitochondrial isoform X1.	0.536
AIFM1	TXNRD3	A0A341CIX5	A0A341CWK8	Apoptosis-inducing factor 1, mitochondrial.	Thioredoxin reductase 3 isoform X1.	0.536
AIFM2	DLD	A0A341D2V3	A0A341B581	Apoptosis-inducing factor 2 isoform X1.	Dihydrolipoyl dehydrogenase.	0.536
AIFM2	DMGDH	A0A341D2V3	A0A341C9M7	Apoptosis-inducing factor 2 isoform X1.	Dimethylglycine dehydrogenase, mitochondrial isoform X1.	0.439
AIFM2	ETFDH	A0A341D2V3	A0A341BGC5	Apoptosis-inducing factor 2 isoform X1.	Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.	0.499
AIFM2	GSR	A0A341D2V3	A0A341D267	Apoptosis-inducing factor 2 isoform X1.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.662
AIFM2	L2HGDH	A0A341D2V3	A0A341D6S2	Apoptosis-inducing factor 2 isoform X1.	L-2-hydroxyglutarate dehydrogenase, mitochondrial isoform X1.	0.539
AIFM2	PDPR	A0A341D2V3	A0A341AKU4	Apoptosis-inducing factor 2 isoform X1.	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X1.	0.439
AIFM2	PIPOX	A0A341D2V3	A0A341AR56	Apoptosis-inducing factor 2 isoform X1.	Peroxisomal sarcosine oxidase.	0.771
AIFM2	SARDH	A0A341D2V3	A0A341CTU1	Apoptosis-inducing factor 2 isoform X1.	Sarcosine dehydrogenase, mitochondrial.	0.439
AIFM2	TXNRD1	A0A341D2V3	A0A341AB81	Apoptosis-inducing factor 2 isoform X1.	Thioredoxin reductase 1, cytoplasmic.	0.536
AIFM2	TXNRD2	A0A341D2V3	A0A341CXT6	Apoptosis-inducing factor 2 isoform X1.	Thioredoxin reductase 2, mitochondrial isoform X1.	0.536