(14 nodes) Kringle superfamily network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (565 aa)
	ROR1	LOW QUALITY PROTEIN: inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (932 aa)
	KREMEN2	Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
	HABP2	Hyaluronan-binding protein 2 isoform X1. (553 aa)
	HGF	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
	PLG	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (814 aa)
	PRSS12	Neurotrypsin; Belongs to the peptidase S1 family. (861 aa)
	F12	LOW QUALITY PROTEIN: coagulation factor XII. (619 aa)
	HGFAC	Hepatocyte growth factor activator isoform X2. (664 aa)
	PLAU	Urokinase-type plasminogen activator. (431 aa)
	MST1	LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. (732 aa)
	ROR2	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (920 aa)
	PIK3IP1	Phosphoinositide-3-kinase-interacting protein 1 isoform X1. (264 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F12	F2	A0A341BFB1	A0A341BRQ7	LOW QUALITY PROTEIN: coagulation factor XII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.596
F12	HABP2	A0A341BFB1	A0A341CAL0	LOW QUALITY PROTEIN: coagulation factor XII.	Hyaluronan-binding protein 2 isoform X1.	0.513
F12	HGF	A0A341BFB1	A0A341C1A0	LOW QUALITY PROTEIN: coagulation factor XII.	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family.	0.695
F12	MST1	A0A341BFB1	A0A341ATW5	LOW QUALITY PROTEIN: coagulation factor XII.	LOW QUALITY PROTEIN: hepatocyte growth factor-like protein; Belongs to the peptidase S1 family.	0.693
F12	PLG	A0A341BFB1	A0A341BNE4	LOW QUALITY PROTEIN: coagulation factor XII.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.957
F12	ROR1	A0A341BFB1	A0A341D0N7	LOW QUALITY PROTEIN: coagulation factor XII.	LOW QUALITY PROTEIN: inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.472
F12	ROR2	A0A341BFB1	A0A341ADM7	LOW QUALITY PROTEIN: coagulation factor XII.	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.472
F2	F12	A0A341BRQ7	A0A341BFB1	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	LOW QUALITY PROTEIN: coagulation factor XII.	0.596
F2	HABP2	A0A341BRQ7	A0A341CAL0	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Hyaluronan-binding protein 2 isoform X1.	0.460
F2	HGFAC	A0A341BRQ7	A0A341BDV1	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Hepatocyte growth factor activator isoform X2.	0.546
F2	PLG	A0A341BRQ7	A0A341BNE4	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.935
HABP2	F12	A0A341CAL0	A0A341BFB1	Hyaluronan-binding protein 2 isoform X1.	LOW QUALITY PROTEIN: coagulation factor XII.	0.513
HABP2	F2	A0A341CAL0	A0A341BRQ7	Hyaluronan-binding protein 2 isoform X1.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.460
HABP2	HGFAC	A0A341CAL0	A0A341BDV1	Hyaluronan-binding protein 2 isoform X1.	Hepatocyte growth factor activator isoform X2.	0.469
HABP2	PLG	A0A341CAL0	A0A341BNE4	Hyaluronan-binding protein 2 isoform X1.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.486
HABP2	ROR1	A0A341CAL0	A0A341D0N7	Hyaluronan-binding protein 2 isoform X1.	LOW QUALITY PROTEIN: inactive tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.472
HABP2	ROR2	A0A341CAL0	A0A341ADM7	Hyaluronan-binding protein 2 isoform X1.	Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.	0.472
HGF	F12	A0A341C1A0	A0A341BFB1	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family.	LOW QUALITY PROTEIN: coagulation factor XII.	0.695
HGF	HGFAC	A0A341C1A0	A0A341BDV1	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family.	Hepatocyte growth factor activator isoform X2.	0.960
HGF	PLG	A0A341C1A0	A0A341BNE4	Hepatocyte growth factor isoform X1; Belongs to the peptidase S1 family.	Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]	0.430