STRINGSTRING
DKK2 DKK2 LRP5 LRP5 DKK1 DKK1 WIF1 WIF1 SFRP5 SFRP5 KREMEN1 KREMEN1 SFRP1 SFRP1 DKK4 DKK4 SOST SOST KREMEN2 KREMEN2 LOC112407988 LOC112407988 LRP6 LRP6 LOC112407979 LOC112407979
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DKK2Dickkopf-related protein 2. (259 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
DKK1Dickkopf-related protein 1. (268 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
SFRP5Secreted frizzled-related protein 5. (446 aa)
KREMEN1Kremen protein 1. (348 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
DKK4LOW QUALITY PROTEIN: dickkopf-related protein 4. (251 aa)
SOSTSclerostin. (212 aa)
KREMEN2Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (461 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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