(56 nodes) Glycine, serine and threonine metabolism network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112414311	LOW QUALITY PROTEIN: myotubularin-related protein 9-like. (541 aa)
	ALAS2	5-aminolevulinate synthase. (594 aa)
	GNMT	Glycine N-methyltransferase. (295 aa)
	THNSL1	Threonine synthase-like 1. (743 aa)
	PHGDH	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	AGXT	Serine--pyruvate aminotransferase. (414 aa)
	GRHPR	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
	SARDH	Sarcosine dehydrogenase, mitochondrial. (918 aa)
	GATM	Glycine amidinotransferase, mitochondrial. (423 aa)
	GCAT	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial. (420 aa)
	LOC112410451	LOW QUALITY PROTEIN: probable low-specificity L-threonine aldolase 2. (388 aa)
	LOC112410696	L-threonine 3-dehydrogenase, mitochondrial. (373 aa)
	ALDH7A1	Alpha-aminoadipic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (539 aa)
	XPNPEP1	xaa-Pro aminopeptidase 1 isoform X6; Belongs to the peptidase M24B family. (730 aa)
	DMGDH	Dimethylglycine dehydrogenase, mitochondrial isoform X1. (866 aa)
	BHMT	Betaine--homocysteine S-methyltransferase 1 isoform X1; Involved in the regulation of homocysteine metabolism. (406 aa)
	LOC112406118	LOW QUALITY PROTEIN: uncharacterized protein LOC112406118; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (400 aa)
	AGXT2	Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (514 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	FASTKD3	FAST kinase domain-containing protein 3, mitochondrial isoform X1. (657 aa)
	SPO11	Meiotic recombination protein SPO11 isoform X1. (395 aa)
	PGAM2	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
	MTMR9	Myotubularin-related protein 9. (324 aa)
	LOC112400497	Myotubularin-related protein 9-like. (225 aa)
	GLYCTK	Glycerate kinase isoform X1. (523 aa)
	ALAS1	5-aminolevulinate synthase. (640 aa)
	CHDH	Choline dehydrogenase. (594 aa)
	AOC2	Amine oxidase. (756 aa)
	PSPH	Phosphoserine phosphatase. (225 aa)
	LOC112399121	Amine oxidase; Belongs to the copper/topaquinone oxidase family. (206 aa)
	LOC112398893	Amine oxidase. (763 aa)
	THNSL2	Threonine synthase-like 2. (484 aa)
	PNPLA8	Calcium-independent phospholipase A2-gamma isoform X1. (784 aa)
	DAO	D-amino-acid oxidase. (347 aa)
	DLD	Dihydrolipoyl dehydrogenase. (509 aa)
	SDS	L-serine dehydratase/L-threonine deaminase. (328 aa)
	SDSL	Serine dehydratase-like. (329 aa)
	GAMT	Guanidinoacetate N-methyltransferase. (312 aa)
	PPHLN1	Periphilin-1 isoform X1. (374 aa)
	LOC112395668	Phosphoserine aminotransferase. (370 aa)
	LOC112395635	Glycine cleavage system H protein, mitochondrial-like. (129 aa)
	AMT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (403 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
	SRR	Serine racemase. (344 aa)
	XPNPEP3	Probable Xaa-Pro aminopeptidase 3 isoform X1. (507 aa)
	PIPOX	Peroxisomal sarcosine oxidase. (390 aa)
	LOC112392791	LOW QUALITY PROTEIN: bisphosphoglycerate mutase-like. (258 aa)
	MAOA	Amine oxidase. (527 aa)
	PGAM1	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
	GCSH	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (207 aa)
	CTH	Cystathionine gamma-lyase isoform X1. (436 aa)
	GLDC	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1020 aa)
	MAOB	Amine oxidase. (520 aa)
	PEPD	xaa-Pro dipeptidase. (493 aa)
	LOC112415038	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (173 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	AGXT2	A0A341CYD8	A0A341C6J1	Serine--pyruvate aminotransferase.	Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.968
AGXT	ALAS1	A0A341CYD8	A0A341BHH0	Serine--pyruvate aminotransferase.	5-aminolevulinate synthase.	0.867
AGXT	ALAS2	A0A341CYD8	A0A341D7T7	Serine--pyruvate aminotransferase.	5-aminolevulinate synthase.	0.903
AGXT	ALDH7A1	A0A341CYD8	A0A341CG91	Serine--pyruvate aminotransferase.	Alpha-aminoadipic semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.735
AGXT	AMT	A0A341CYD8	A0A341AUF4	Serine--pyruvate aminotransferase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.950
AGXT	BHMT	A0A341CYD8	A0A341C9L3	Serine--pyruvate aminotransferase.	Betaine--homocysteine S-methyltransferase 1 isoform X1; Involved in the regulation of homocysteine metabolism.	0.853
AGXT	CHDH	A0A341CYD8	A0A341BH25	Serine--pyruvate aminotransferase.	Choline dehydrogenase.	0.640
AGXT	CTH	A0A341CYD8	A0A341AKG1	Serine--pyruvate aminotransferase.	Cystathionine gamma-lyase isoform X1.	0.718
AGXT	DAO	A0A341CYD8	A0A341B6H1	Serine--pyruvate aminotransferase.	D-amino-acid oxidase.	0.938
AGXT	DLD	A0A341CYD8	A0A341B581	Serine--pyruvate aminotransferase.	Dihydrolipoyl dehydrogenase.	0.895
AGXT	DMGDH	A0A341CYD8	A0A341C9M7	Serine--pyruvate aminotransferase.	Dimethylglycine dehydrogenase, mitochondrial isoform X1.	0.729
AGXT	GATM	A0A341CYD8	A0A341CTE8	Serine--pyruvate aminotransferase.	Glycine amidinotransferase, mitochondrial.	0.899
AGXT	GCAT	A0A341CYD8	A0A341CRF9	Serine--pyruvate aminotransferase.	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial.	0.923
AGXT	GCSH	A0A341CYD8	A0A341AL49	Serine--pyruvate aminotransferase.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.816
AGXT	GLDC	A0A341CYD8	A0A341AH48	Serine--pyruvate aminotransferase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.937
AGXT	GLYCTK	A0A341CYD8	A0A341BHJ1	Serine--pyruvate aminotransferase.	Glycerate kinase isoform X1.	0.954
AGXT	GNMT	A0A341CYD8	A0A341D547	Serine--pyruvate aminotransferase.	Glycine N-methyltransferase.	0.919
AGXT	GRHPR	A0A341CYD8	A0A341CVN9	Serine--pyruvate aminotransferase.	Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.947
AGXT	LOC112395635	A0A341CYD8	A0A341AYX4	Serine--pyruvate aminotransferase.	Glycine cleavage system H protein, mitochondrial-like.	0.816
AGXT	LOC112395668	A0A341CYD8	A0A341AZH7	Serine--pyruvate aminotransferase.	Phosphoserine aminotransferase.	0.804