STRINGSTRING
AKT2 AKT2 BAX BAX ERAS ERAS GSK3B GSK3B PDGFD PDGFD AXL AXL PIK3R2 PIK3R2 VEGFA VEGFA EIF4EBP1 EIF4EBP1 EGFR EGFR NRG1 NRG1 NRAS NRAS CSDE1 CSDE1 JAK1 JAK1 MAPK1 MAPK1 PDGFA PDGFA GRB2 GRB2 PDGFB PDGFB PRKCA PRKCA LOC112408488 LOC112408488 AKT1 AKT1 MET MET RPS6KB1 RPS6KB1 LOC112407246 LOC112407246 RAF1 RAF1 TGFA TGFA FGFR2 FGFR2 PIK3CA PIK3CA LOC112406592 LOC112406592 FOXO3 FOXO3 LOC112406614 LOC112406614 BCL2 BCL2 AKT3 AKT3 SOS1 SOS1 GAS6 GAS6 PIK3R1 PIK3R1 HGF HGF NRG2 NRG2 PIK3CB PIK3CB ARAF ARAF PIK3CD PIK3CD MTOR MTOR BAD BAD SHC4 SHC4 CEP152 CEP152 HRAS HRAS RPS6KB2 RPS6KB2 SHC1 SHC1 IL6R IL6R RPS6 RPS6 KDR KDR MAP2K2 MAP2K2 PDGFRA PDGFRA LOC112400438 LOC112400438 PDGFC PDGFC FGF2 FGF2 PTEN PTEN STAT3 STAT3 PRKCB PRKCB MAPK3 MAPK3 BCL2L1 BCL2L1 BCL2L11 BCL2L11 SRC SRC ERBB2 ERBB2 PLCG1 PLCG1 EIF4E1B EIF4E1B BRAF BRAF EGF EGF PRKCG PRKCG EIF4E2 EIF4E2 SHC2 SHC2 IL6 IL6 ERBB3 ERBB3 GAB1 GAB1 EIF4E EIF4E NF1 NF1 PLCG2 PLCG2 JAK2 JAK2 MAP2K1 MAP2K1 SOS2 SOS2 FGFR3 FGFR3 PDGFRB PDGFRB LOC112392089 LOC112392089 TBCA TBCA IGF1R IGF1R KRAS KRAS IGF1 IGF1 SHC3 SHC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
BAXApoptosis regulator BAX. (192 aa)
ERASGTPase ERas. (225 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (396 aa)
AXLTyrosine-protein kinase receptor UFO. (887 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform isoform X1. (699 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC112407246LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (156 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC112406592Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa)
FOXO3Forkhead box protein O3. (672 aa)
LOC112406614LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
GAS6Growth arrest-specific protein 6. (540 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform isoform X2. (850 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
BADBcl2-associated agonist of cell death. (168 aa)
SHC4SHC-transforming protein 4 isoform X1. (630 aa)
CEP152Centrosomal protein of 152 kDa. (1724 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
KDRVascular endothelial growth factor receptor 2 isoform X4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (314 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
SRCTyrosine-protein kinase. (601 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (253 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
SHC2SHC-transforming protein 2. (426 aa)
IL6Interleukin-6. (208 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3 isoform X1. (1337 aa)
GAB1GRB2-associated-binding protein 1 isoform X3. (724 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
NF1Neurofibromin isoform X1. (2841 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
KRASGTPase KRas isoform X3. (227 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
SHC3SHC-transforming protein 3. (470 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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