(93 nodes) Viral protein interaction with cytokine and cytokine receptor network (Neophocaena asiaeorientalis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	LOC112392000	C-X-C motif chemokine. (74 aa)
	IL2RA	Interleukin-2 receptor subunit alpha. (275 aa)
	LTBR	Tumor necrosis factor receptor superfamily member 3. (421 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (445 aa)
	IL34	Interleukin-34. (219 aa)
	LOC112394151	C-C motif chemokine. (99 aa)
	CSF1R	Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
	LOC112394306	C-C motif chemokine. (97 aa)
	IL6	Interleukin-6. (208 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (205 aa)
	CXCL12	Stromal cell-derived factor 1 isoform X3; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	CCL28	C-C motif chemokine. (127 aa)
	TNFSF10	Tumor necrosis factor ligand superfamily member. (288 aa)
	CCL20	C-C motif chemokine. (97 aa)
	CSF1	Macrophage colony-stimulating factor 1. (513 aa)
	LOC112398031	Lymphotactin-like. (111 aa)
	CCR4	C-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (359 aa)
	LOC112398058	Lymphotactin-like. (111 aa)
	IL18RAP	Interleukin-18 receptor accessory protein isoform X1. (584 aa)
	IL18R1	Interleukin-18 receptor 1 isoform X1. (555 aa)
	IL37	LOW QUALITY PROTEIN: interleukin-37. (145 aa)
	LOC112399992	C-C motif chemokine. (94 aa)
	CCL25	C-C motif chemokine 25. (153 aa)
	CCR6	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	CCR10	C-C chemokine receptor type 10; Belongs to the G-protein coupled receptor 1 family. (363 aa)
	IL20RB	Interleukin-20 receptor subunit beta isoform X1. (342 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14 isoform X1; Belongs to the tumor necrosis factor family. (311 aa)
	CCR7	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	CX3CL1	LOW QUALITY PROTEIN: fractalkine. (378 aa)
	CCL22	C-C motif chemokine. (93 aa)
	LOC112401433	Tumor necrosis factor receptor superfamily member 10B-like. (456 aa)
	IL6R	Interleukin-6 receptor subunit alpha. (465 aa)
	CCL1	C-C motif chemokine 1 isoform X1. (93 aa)
	CCL17	LOW QUALITY PROTEIN: C-C motif chemokine 17. (102 aa)
	TNFRSF10A	Tumor necrosis factor receptor superfamily member 10A isoform X1. (452 aa)
	LOC112401755	C-C motif chemokine 13-like. (129 aa)
	LOC112402267	Tumor necrosis factor receptor superfamily member 22-like. (321 aa)
	TNFRSF1B	Tumor necrosis factor receptor superfamily member 1B. (454 aa)
	IL20	LOW QUALITY PROTEIN: interleukin-20. (190 aa)
	IL10	Interleukin-10. (178 aa)
	IL19	Interleukin-19. (177 aa)
	CCR3	C-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (358 aa)
	IL24	Interleukin-24 isoform X1. (183 aa)
	LOC112403768	C-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	CCR9	C-C chemokine receptor type 9 isoform X1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	CCR1	C-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	CXCL14	C-X-C motif chemokine 14. (99 aa)
	CCR2	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
	XCR1	Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (333 aa)
	IL10RA	Interleukin-10 receptor subunit alpha isoform X1. (594 aa)
	CXCR5	C-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	ACKR3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	CCL27	C-C motif chemokine 27. (88 aa)
	CCL21	C-C motif chemokine 21 isoform X1. (131 aa)
	LOC112405641	C-X-C motif chemokine. (104 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	LOC112405635	C-X-C motif chemokine. (104 aa)
	CXCL10	C-X-C motif chemokine. (103 aa)
	LOC112405696	C-X-C motif chemokine. (112 aa)
	CXCL9	C-X-C motif chemokine. (160 aa)
	LOC112405468	Uncharacterized protein LOC112405468. (87 aa)
	CCL19	C-C motif chemokine. (174 aa)
	LOC112405603	C-X-C motif chemokine. (104 aa)
	LOC112405640	C-X-C motif chemokine. (113 aa)
	CCR8	C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CXCL11	C-X-C motif chemokine 11 isoform X2. (100 aa)
	PPBP	C-X-C motif chemokine. (119 aa)
	CXCL13	C-X-C motif chemokine 13. (109 aa)
	LOC112408083	C-C motif chemokine. (90 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1. (581 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	LOC112413276	C-C motif chemokine. (112 aa)
	CXCR4	C-X-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
	CXCR1	C-X-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
	LOC112411917	C-X-C chemokine receptor type 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	RUFY4	RUN and FYVE domain-containing protein 4 isoform X1. (571 aa)
	ACKR4	Atypical chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (350 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (600 aa)
	CXCR3	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	IL20RA	Interleukin-20 receptor subunit alpha. (502 aa)
	IL10RB	Interleukin-10 receptor subunit beta isoform X1. (361 aa)
	LOC112408084	C-C motif chemokine 3-like. (87 aa)
	CCL5	C-C motif chemokine. (91 aa)
	LOC112408041	C-C motif chemokine. (95 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	LOC112408139	C-C motif chemokine. (96 aa)
	LOC112408113	C-C motif chemokine. (122 aa)
	LOC112408082	C-C motif chemokine. (92 aa)
	CCL16	C-C motif chemokine. (120 aa)
	CX3CR1	CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACKR3	CCL1	A0A341C168	A0A341BMM2	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 1 isoform X1.	0.460
ACKR3	CCL16	A0A341C168	A0A341CFT0	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.646
ACKR3	CCL19	A0A341C168	A0A341C5I7	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.755
ACKR3	CCL20	A0A341C168	A0A341B2I9	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.505
ACKR3	CCL21	A0A341C168	A0A341C418	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 21 isoform X1.	0.796
ACKR3	CCL27	A0A341C168	A0A341C3X9	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine 27.	0.672
ACKR3	CCL5	A0A341C168	A0A341CHH1	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C motif chemokine.	0.573
ACKR3	CCR2	A0A341C168	A0A341BZS1	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.613
ACKR3	CCR6	A0A341C168	A0A341BG61	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family.	0.611
ACKR3	CCR7	A0A341C168	A0A341BI40	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.623
ACKR3	CCR8	A0A341C168	A0A341C5W6	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-C chemokine receptor type 8; Belongs to the G-protein coupled receptor 1 family.	0.570
ACKR3	CX3CL1	A0A341C168	A0A341BK30	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: fractalkine.	0.530
ACKR3	CXCL10	A0A341C168	A0A341C524	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.714
ACKR3	CXCL11	A0A341C168	A0A341C610	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine 11 isoform X2.	0.929
ACKR3	CXCL12	A0A341C168	A0A341AZT3	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Stromal cell-derived factor 1 isoform X3; Belongs to the intercrine alpha (chemokine CxC) family.	0.998
ACKR3	CXCL13	A0A341C168	A0A341C656	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine 13.	0.649
ACKR3	CXCL8	A0A341C168	A0A341C4Z1	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family.	0.607
ACKR3	CXCL9	A0A341C168	A0A341C538	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C motif chemokine.	0.654
ACKR3	CXCR1	A0A341C168	A0A341CXM2	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family.	0.480
ACKR3	CXCR3	A0A341C168	A0A341CKR9	Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	C-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family.	0.715