STRINGSTRING
FCGBP FCGBP ANGPT2 ANGPT2 EGLN2 EGLN2 PIK3R2 PIK3R2 EGLN1 EGLN1 LOC112414233 LOC112414233 XK XK CDKN1A CDKN1A VEGFA VEGFA EIF4EBP1 EIF4EBP1 ELOC ELOC HK1 HK1 HKDC1 HKDC1 EGFR EGFR LOC112412913 LOC112412913 VHL VHL LOC112412867 LOC112412867 EDN1 EDN1 PGK1 PGK1 MAPK1 MAPK1 ARNT ARNT TLR4 TLR4 LDHAL6B LDHAL6B PRKCA PRKCA ELOB ELOB CREBBP CREBBP IFNGR1 IFNGR1 PFKL PFKL IFNGR2 IFNGR2 AKT1 AKT1 RPS6KB1 RPS6KB1 ANGPT1 ANGPT1 ENO4 ENO4 PIK3CA PIK3CA LOC112406614 LOC112406614 FLT1 FLT1 BCL2 BCL2 TEK TEK PFKP PFKP TFRC TFRC NOS3 NOS3 AKT3 AKT3 PIK3R1 PIK3R1 HK2 HK2 LTF LTF PIK3CB PIK3CB PIK3CD PIK3CD INS INS MTOR MTOR RELA RELA NPPA NPPA ENO1 ENO1 TIMP1 TIMP1 RPS6KB2 RPS6KB2 HIF1A HIF1A LOC112401637 LOC112401637 IL6R IL6R RPS6 RPS6 CAMK2B CAMK2B LOC112400470 LOC112400470 INSR INSR PDHB PDHB MAP2K2 MAP2K2 LOC112399878 LOC112399878 LOC112400480 LOC112400480 LOC112400438 LOC112400438 MKNK1 MKNK1 SERPINE1 SERPINE1 SLC2A1 SLC2A1 CAMK2D CAMK2D STAT3 STAT3 EPO EPO LOC112399194 LOC112399194 LOC112399877 LOC112399877 PRKCB PRKCB ALDOA ALDOA MAPK3 MAPK3 HMOX1 HMOX1 ERBB2 ERBB2 PLCG1 PLCG1 EIF4E1B EIF4E1B ANGPT4 ANGPT4 EGLN3 EGLN3 EGF EGF CUL2 CUL2 HK3 HK3 PRKCG PRKCG EIF4E2 EIF4E2 CAMK2G CAMK2G MKNK2 MKNK2 IL6 IL6 PDHA1 PDHA1 RBX1 RBX1 EP300 EP300 PFKM PFKM ENO3 ENO3 NOS2 NOS2 PDHA2 PDHA2 EIF4E EIF4E IFNG IFNG NFKB1 NFKB1 ALDOC ALDOC PLCG2 PLCG2 ALDOB ALDOB MAP2K1 MAP2K1 ENO2 ENO2 LTBR LTBR LDHB LDHB LOC112392089 LOC112392089 TBCA TBCA GAPDH GAPDH CDKN1B CDKN1B IGF1R IGF1R PFKFB3 PFKFB3 CAMK2A CAMK2A IGF1 IGF1 PDK1 PDK1 ARSI ARSI AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FCGBPIgGFc-binding protein. (2584 aa)
ANGPT2Angiopoietin-2 isoform X1. (496 aa)
EGLN2Egl nine homolog 2 isoform X1. (425 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
EGLN1Egl nine homolog 1. (225 aa)
LOC112414233Cytochrome b-245 heavy chain isoform X1. (570 aa)
XKXK-related protein. (444 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
ELOCelongin-C; Belongs to the SKP1 family. (112 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
LOC112412913L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
VHLVon Hippel-Lindau disease tumor suppressor. (219 aa)
LOC112412867LOW QUALITY PROTEIN: L-lactate dehydrogenase C chain-like; Belongs to the LDH/MDH superfamily. (224 aa)
EDN1Endothelin-1. (202 aa)
PGK1Phosphoglycerate kinase. (417 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ARNTAryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
LDHAL6BLOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6B; Belongs to the LDH/MDH superfamily. (335 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
ELOBelongin-B. (118 aa)
CREBBPCREB-binding protein. (2443 aa)
IFNGR1Interferon gamma receptor 1 isoform X1. (468 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (732 aa)
IFNGR2Interferon gamma receptor 2 isoform X2. (364 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
ENO4Enolase 4. (616 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC112406614LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
FLT1Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (803 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
TFRCTransferrin receptor protein 1 isoform X1. (772 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HK2Hexokinase-2. (917 aa)
LTFLactotransferrin isoform X1; Belongs to the transferrin family. (711 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
RELATranscription factor p65. (562 aa)
NPPANatriuretic peptides A. (152 aa)
ENO1Alpha-enolase. (444 aa)
TIMP1Metalloproteinase inhibitor 1. (260 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
LOC112401637L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (374 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
RPS640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (808 aa)
LOC112400470Serotransferrin-like; Belongs to the transferrin family. (707 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
LOC112399878Zonadhesin-like. (2483 aa)
LOC112400480Inhibitor of carbonic anhydrase; Belongs to the transferrin family. (700 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MKNK1MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily. (435 aa)
SERPINE1Plasminogen activator inhibitor 1 isoform X1; Belongs to the serpin family. (402 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta; Belongs to the protein kinase superfamily. (449 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EPOErythropoietin. (266 aa)
LOC112399194Keratin-associated protein 10-10-like. (91 aa)
LOC112399877Zonadhesin-like. (257 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
ALDOAFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
HMOX1Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (288 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (253 aa)
ANGPT4Angiopoietin-4. (498 aa)
EGLN3Egl nine homolog 3. (239 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
CUL2Cullin-2; Belongs to the cullin family. (745 aa)
HK3Hexokinase-3 isoform X1. (989 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (507 aa)
MKNK2MAP kinase-interacting serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (463 aa)
IL6Interleukin-6. (208 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X2. (108 aa)
EP300Histone acetyltransferase p300. (2399 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
ENO3Beta-enolase isoform X1. (546 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
PDHA2annotation not available (387 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (303 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
ALDOCFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
ALDOBFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ENO2Gamma-enolase. (434 aa)
LTBRTumor necrosis factor receptor superfamily member 3. (421 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
TBCATubulin-specific chaperone A; Belongs to the TBCA family. (108 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (333 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
PFKFB36-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform X1. (521 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (478 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
ARSIArylsulfatase I. (573 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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