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| | BAX | Apoptosis regulator BAX. (192 aa) |
| | RELA | Transcription factor p65. (562 aa) |
| | HRAS | GTPase HRas isoform X1. (189 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa) |
| | LOC112402235 | Interferon-induced transmembrane protein 3-like. (146 aa) |
| | CTSD | Cathepsin D; Belongs to the peptidase A1 family. (411 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | S1PR5 | Sphingosine 1-phosphate receptor 5. (506 aa) |
| | MAP2K2 | Dual specificity mitogen-activated protein kinase kinase 2. (303 aa) |
| | PPP2R3A | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1149 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa) |
| | CERS4 | Ceramide synthase 4. (393 aa) |
| | S1PR2 | Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa) |
| | LOC112400438 | Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa) |
| | RAC1 | Ras-related C3 botulinum toxin substrate 1. (148 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | ABCC1 | Multidrug resistance-associated protein 1 isoform X1. (1464 aa) |
| | MAPK3 | Mitogen-activated protein kinase 3. (265 aa) |
| | ASAH2 | Neutral ceramidase. (757 aa) |
| | SGMS1 | Phosphatidylcholine:ceramide cholinephosphotransferase 1. (413 aa) |
| | NSMAF | Protein FAN. (1255 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa) |
| | GNAI3 | Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa) |
| | SGMS2 | Phosphatidylcholine:ceramide cholinephosphotransferase 2. (365 aa) |
| | FYN | Tyrosine-protein kinase. (537 aa) |
| | S1PR4 | Sphingosine 1-phosphate receptor 4. (489 aa) |
| | TNF | Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | LOC112395611 | Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa) |
| | MAPK11 | Mitogen-activated protein kinase. (376 aa) |
| | GNAI1 | Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa) |
| | GNAI2 | Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa) |
| | RHOA | Transforming protein RhoA. (193 aa) |
| | PLD2 | Phospholipase. (933 aa) |
| | SPTLC2 | Serine palmitoyltransferase 2. (537 aa) |
| | ROCK2 | Rho-associated protein kinase 2 isoform X1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1302 aa) |
| | MAPK12 | Mitogen-activated protein kinase. (424 aa) |
| | CERS5 | Ceramide synthase 5. (353 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | NFKB1 | Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa) |
| | PLD1 | Phospholipase. (1151 aa) |
| | SPTLC3 | Serine palmitoyltransferase 3 isoform X1. (548 aa) |
| | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A. (445 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (311 aa) |
| | LOC112392089 | RAC-alpha serine/threonine-protein kinase. (138 aa) |
| | BID | BH3-interacting domain death agonist isoform X1. (326 aa) |
| | CERS3 | Ceramide synthase 3. (389 aa) |
| | ADAMTS17 | A disintegrin and metalloproteinase with thrombospondin motifs 17. (881 aa) |
| | S1PR3 | Sphingosine 1-phosphate receptor 3; Belongs to the G-protein coupled receptor 1 family. (378 aa) |
| | KRAS | GTPase KRas isoform X3. (227 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa) |
| | PLCB2 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa) |
| | PLCB3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa) |
| | PPP2R5B | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (497 aa) |
| | MS4A2 | High affinity immunoglobulin epsilon receptor subunit beta. (242 aa) |
| | PIK3CD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa) |
| | GAB2 | GRB2-associated-binding protein 2 isoform X1. (670 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa) |
| | FCER1A | High affinity immunoglobulin epsilon receptor subunit alpha isoform X1. (258 aa) |
| | ADORA1 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (326 aa) |
| | PTK6 | LOW QUALITY PROTEIN: protein-tyrosine kinase 6. (367 aa) |
| | S1PR1 | Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa) |
| | PPP2R5E | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa) |
| | LOC112403425 | Protein kinase C zeta type-like. (85 aa) |
| | PPP2R5A | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (488 aa) |
| | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | AKT3 | Non-specific serine/threonine protein kinase. (531 aa) |
| | PPP2R1B | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (696 aa) |
| | NOS3 | Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa) |
| | BCL2 | Apoptosis regulator Bcl-2 isoform X1. (233 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (423 aa) |
| | LOC112406592 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa) |
| | CERS6 | Ceramide synthase 6 isoform X1. (384 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa) |
| | FCER1G | High affinity immunoglobulin epsilon receptor subunit gamma. (86 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | AKT1 | RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5 isoform X2. (1366 aa) |
| | PDPK1 | 3-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa) |
| | ASAH1 | Acid ceramidase isoform X1; Belongs to the acid ceramidase family. (395 aa) |
| | PPP2R5C | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (538 aa) |
| | DEGS2 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2 isoform X1. (337 aa) |
| | PRKCZ | LOW QUALITY PROTEIN: protein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (546 aa) |
| | SPTLC1 | Serine palmitoyltransferase 1. (473 aa) |
| | BDKRB2 | B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | RAC3 | Ras-related C3 botulinum toxin substrate 3. (221 aa) |
| | LOC112410281 | annotation not available (287 aa) |
| | GNA13 | Guanine nucleotide-binding protein subunit alpha-13. (282 aa) |
| | SPHK1 | Sphingosine kinase 1. (391 aa) |
| | PRKCA | Non-specific serine/threonine protein kinase. (541 aa) |
| | RAC2 | Ras-related C3 botulinum toxin substrate 2. (197 aa) |
| | ADAMTS19 | A disintegrin and metalloproteinase with thrombospondin motifs 19. (945 aa) |
| | PPP2R2D | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa) |
| | PPP2R3C | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa) |
| | TRAF2 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | MAPK1 | Mitogen-activated protein kinase. (343 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (271 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa) |
| | GNA12 | Guanine nucleotide-binding protein subunit alpha-12. (305 aa) |
| | ADORA3 | Adenosine receptor A3 isoform X1; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | CSDE1 | Cold shock domain-containing protein E1 isoform X1. (798 aa) |
| | NRAS | GTPase NRas. (189 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (244 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | PLCB4 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa) |
| | DEGS1 | Sphingolipid delta(4)-desaturase DES1 isoform X1. (323 aa) |
| | MAPK14 | Mitogen-activated protein kinase. (360 aa) |
| | PPP2R5D | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | PIK3R2 | Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa) |
| | OPRD1 | Delta-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (368 aa) |
| | PPP2R3B | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (578 aa) |
| | CERS1 | Ceramide synthase 1. (239 aa) |
| | PPP2R1A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa) |
| | KNG1 | Kininogen-1 isoform X1. (627 aa) |
| | SPHK2 | Sphingosine kinase 2 isoform X1. (655 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa) |
| | ERAS | GTPase ERas. (225 aa) |
