STRINGSTRING
AKT2 AKT2 FOSB FOSB SPIB SPIB JUND JUND RELB RELB TGFB1 TGFB1 PIK3R2 PIK3R2 JUNB JUNB CALCR CALCR LCK LCK TREM2 TREM2 MAPK13 MAPK13 MAPK14 MAPK14 MAPK9 MAPK9 IKBKB IKBKB SQSTM1 SQSTM1 JAK1 JAK1 FOSL2 FOSL2 TGFBR1 TGFBR1 BLNK BLNK PLCG2 PLCG2 PPP3R2 PPP3R2 NFKB1 NFKB1 CHUK CHUK LOC112393500 LOC112393500 IFNG IFNG PPP3CA PPP3CA MAPK12 MAPK12 STAT2 STAT2 CSF1R CSF1R CREB1 CREB1 FOS FOS MAPK11 MAPK11 MAPK8 MAPK8 TGFB2 TGFB2 TNF TNF LOC112396191 LOC112396191 PPARG PPARG LOC112396195 LOC112396195 PPP3CB PPP3CB IGSF1 IGSF1 FYN FYN CSF1 CSF1 LOC112397896 LOC112397896 TNFRSF11B TNFRSF11B SIRPG SIRPG IL1A IL1A IL1B IL1B LOC112398388 LOC112398388 CAMK4 CAMK4 TGFBR2 TGFBR2 SOCS1 SOCS1 FHL2 FHL2 MAPK3 MAPK3 IL1R1 IL1R1 RAC1 RAC1 ACP5 ACP5 LOC112400438 LOC112400438 TYK2 TYK2 MAP2K7 MAP2K7 MITF MITF BTK BTK IKBKG IKBKG NOX1 NOX1 TEC TEC NCF1 NCF1 CYLD CYLD TAB2 TAB2 SPI1 SPI1 PPP3CC PPP3CC FOSL1 FOSL1 RELA RELA PIK3CD PIK3CD GAB2 GAB2 NFATC2 NFATC2 PIK3CB PIK3CB PTK6 PTK6 FCGR2B FCGR2B LOC112403899 LOC112403899 LOC112403906 LOC112403906 TRAF6 TRAF6 PIK3R1 PIK3R1 IRF9 IRF9 LCP2 LCP2 AKT3 AKT3 TNFRSF11A TNFRSF11A LOC112406422 LOC112406422 KIAA1468 KIAA1468 TNFSF11 TNFSF11 NFATC1 NFATC1 PIK3CA PIK3CA JUN JUN IFNB1 IFNB1 AKT1 AKT1 IFNGR2 IFNGR2 IFNAR1 IFNAR1 IFNAR2 IFNAR2 IFNGR1 IFNGR1 ITGB3 ITGB3 MAP3K14 MAP3K14 MAP2K6 MAP2K6 TAB1 TAB1 SOCS3 SOCS3 GRB2 GRB2 NCF4 NCF4 NFKBIA NFKBIA NOXA1 NOXA1 TRAF2 TRAF2 CTSK CTSK MAP2K1 MAP2K1 NFKB2 NFKB2 TYROBP TYROBP TNFRSF1A TNFRSF1A LOC112392029 LOC112392029 STAT1 STAT1 LOC112392089 LOC112392089 NCF2 NCF2 MAP3K7 MAP3K7 SYK SYK MAPK10 MAPK10 MAPK1 MAPK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FOSBProtein fosB isoform X1. (341 aa)
SPIBTranscription factor Spi-B isoform X1. (262 aa)
JUNDTranscription factor jun-D. (345 aa)
RELBTranscription factor RelB. (578 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
JUNBTranscription factor jun-B. (347 aa)
CALCRCalcitonin receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (524 aa)
LCKTyrosine-protein kinase. (509 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
SQSTM1Sequestosome-1 isoform X1. (440 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
FOSL2Fos-related antigen 2 isoform X1. (327 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
BLNKB-cell linker protein isoform X1. (528 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (229 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
LOC112393500Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (192 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
MAPK12Mitogen-activated protein kinase. (424 aa)
STAT2Signal transducer and activator of transcription. (899 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
FOSProto-oncogene c-Fos. (380 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC112396191Leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1. (465 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
LOC112396195Leukocyte immunoglobulin-like receptor subfamily B member 3. (620 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
IGSF1Immunoglobulin superfamily member 1 isoform X1. (1342 aa)
FYNTyrosine-protein kinase. (537 aa)
CSF1Macrophage colony-stimulating factor 1. (513 aa)
LOC112397896LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 3. (469 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
SIRPGSignal-regulatory protein gamma. (326 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LOC112398388Tyrosine-protein phosphatase non-receptor type substrate 1-like. (287 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV isoform X1. (529 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
SOCS1Suppressor of cytokine signaling 1. (214 aa)
FHL2Four and a half LIM domains protein 2. (279 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (723 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (148 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (349 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1214 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7. (399 aa)
MITFMicrophthalmia-associated transcription factor isoform X1. (526 aa)
BTKTyrosine-protein kinase. (687 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (569 aa)
TECTyrosine-protein kinase. (633 aa)
NCF1Neutrophil cytosol factor 1 isoform X1. (393 aa)
CYLDUbiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (953 aa)
TAB2TGF-beta-activated kinase 1 and MAP3K7-binding protein 2. (693 aa)
SPI1Transcription factor PU.1 isoform X1. (271 aa)
PPP3CCSerine/threonine-protein phosphatase. (549 aa)
FOSL1Fos-related antigen 1 isoform X2. (271 aa)
RELATranscription factor p65. (562 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
GAB2GRB2-associated-binding protein 2 isoform X1. (670 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PTK6LOW QUALITY PROTEIN: protein-tyrosine kinase 6. (367 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (326 aa)
LOC112403899Low affinity immunoglobulin gamma Fc region receptor II-like isoform X1. (188 aa)
LOC112403906Low affinity immunoglobulin gamma Fc region receptor III-like isoform X1. (257 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
IRF9LOW QUALITY PROTEIN: interferon regulatory factor 9. (478 aa)
LCP2Lymphocyte cytosolic protein 2 isoform X1. (555 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (689 aa)
LOC112406422Leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1. (346 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X2. (1214 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
IFNB1Interferon beta. (185 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
IFNGR2Interferon gamma receptor 2 isoform X2. (364 aa)
IFNAR1Interferon alpha/beta receptor 1 isoform X1. (561 aa)
IFNAR2Interferon alpha/beta receptor 2 isoform X1. (533 aa)
IFNGR1Interferon gamma receptor 1 isoform X1. (468 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (789 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (961 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1. (504 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NCF4Neutrophil cytosol factor 4. (339 aa)
NFKBIANF-kappa-B inhibitor alpha. (324 aa)
NOXA1NADPH oxidase activator 1. (626 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
CTSKCathepsin K isoform X1; Belongs to the peptidase C1 family. (358 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (126 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
LOC112392029Signal-regulatory protein beta-1-like. (271 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
SYKTyrosine-protein kinase. (626 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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