(70 nodes) RIG-I-like receptor signaling pathway network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFKBIB	NF-kappa-B inhibitor beta. (353 aa)
	OTUD5	OTU domain-containing protein 5. (447 aa)
	IRF3	Interferon regulatory factor 3. (419 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1672 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
	SIKE1	Suppressor of IKBKE 1. (207 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (324 aa)
	ISG15	Ubiquitin-like protein ISG15. (170 aa)
	TRIM65	Tripartite motif-containing protein 65 isoform X1. (586 aa)
	TRIM47	Tripartite motif-containing protein 47. (400 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X isoform X1; Belongs to the DEAD box helicase family. (662 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (517 aa)
	RNF125	E3 ubiquitin-protein ligase RNF125. (232 aa)
	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25. (635 aa)
	COIL	Coilin. (573 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (497 aa)
	LOC112407025	Interferon alpha-1-like. (189 aa)
	IFNB1	Interferon beta. (185 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	IFNK	Interferon kappa. (207 aa)
	CXCL10	C-X-C motif chemokine. (103 aa)
	CXCL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
	TMEM173	Stimulator of interferon genes protein isoform X1. (378 aa)
	AZI2	5-azacytidine-induced protein 2. (393 aa)
	NLRX1	NLR family member X1 isoform X1. (973 aa)
	IKBKE	Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (773 aa)
	IRF7	Interferon regulatory factor 7. (474 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	RELA	Transcription factor p65. (562 aa)
	TKFC	triokinase/FMN cyclase isoform X1. (577 aa)
	CYLD	Ubiquitin carboxyl-terminal hydrolase CYLD isoform X1; Belongs to the peptidase C19 family. (953 aa)
	FGFR1OP2	FGFR1 oncogene partner 2 isoform X1. (253 aa)
	IKBKG	NF-kappa-B essential modulator isoform X1. (498 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (163 aa)
	DHX58	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DHX58. (683 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (88 aa)
	TBKBP1	TANK-binding kinase 1-binding protein 1. (505 aa)
	MAVS	Mitochondrial antiviral-signaling protein isoform X1. (581 aa)
	LOC112396076	ATP-dependent RNA helicase DDX3X-like; Belongs to the DEAD box helicase family. (656 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LOC112395028	LOW QUALITY PROTEIN: interferon alpha-8-like. (171 aa)
	LOC112395025	Interferon omega-1-like. (250 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	LOC112395029	LOW QUALITY PROTEIN: interferon alpha-8-like. (171 aa)
	LOC112395020	Interferon alpha-1-like. (189 aa)
	MAPK11	Mitogen-activated protein kinase. (376 aa)
	LOC112395033	Interferon omega-1-like. (250 aa)
	RIPK1	Receptor-interacting serine/threonine-protein kinase 1. (667 aa)
	IFNE	Interferon epsilon. (193 aa)
	LOC112395027	Interferon alpha-1-like. (189 aa)
	LOC112395023	Interferon alpha-1-like. (189 aa)
	MAPK12	Mitogen-activated protein kinase. (424 aa)
	IFIH1	Interferon-induced helicase C domain-containing protein 1. (1023 aa)
	TBK1	Serine/threonine-protein kinase TBK1. (729 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (425 aa)
	RNF135	LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF135. (447 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (311 aa)
	LOC112392044	Ubiquitin-like protein ATG12. (54 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	A0A341BBS7	A0A341CA44	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.998
ATG12	DHX58	A0A341BBS7	A0A341BD10	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DHX58.	0.571
ATG12	FADD	A0A341BBS7	A0A341BTL7	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.479
ATG12	IFIH1	A0A341BBS7	A0A341ARB8	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Interferon-induced helicase C domain-containing protein 1.	0.697
ATG12	MAVS	A0A341BBS7	A0A341BAR9	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Mitochondrial antiviral-signaling protein isoform X1.	0.913
ATG12	NLRX1	A0A341BBS7	A0A341C0M3	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	NLR family member X1 isoform X1.	0.529
ATG5	ATG12	A0A341CA44	A0A341BBS7	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.998
ATG5	CASP10	A0A341CA44	A0A341CGP1	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-10; Belongs to the peptidase C14A family.	0.544
ATG5	CASP8	A0A341CA44	A0A341CEH2	Autophagy protein 5; Involved in autophagic vesicle formation.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.669
ATG5	DHX58	A0A341CA44	A0A341BD10	Autophagy protein 5; Involved in autophagic vesicle formation.	LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DHX58.	0.707
ATG5	FADD	A0A341CA44	A0A341BTL7	Autophagy protein 5; Involved in autophagic vesicle formation.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.899
ATG5	IFIH1	A0A341CA44	A0A341ARB8	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon-induced helicase C domain-containing protein 1.	0.794
ATG5	LOC112392044	A0A341CA44	A0A341AFG0	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12.	0.998
ATG5	MAVS	A0A341CA44	A0A341BAR9	Autophagy protein 5; Involved in autophagic vesicle formation.	Mitochondrial antiviral-signaling protein isoform X1.	0.956
ATG5	NLRX1	A0A341CA44	A0A341C0M3	Autophagy protein 5; Involved in autophagic vesicle formation.	NLR family member X1 isoform X1.	0.617
ATG5	RIPK1	A0A341CA44	A0A341AUM8	Autophagy protein 5; Involved in autophagic vesicle formation.	Receptor-interacting serine/threonine-protein kinase 1.	0.481
ATG5	TBK1	A0A341CA44	A0A341AQ18	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase TBK1.	0.441
ATG5	TNF	A0A341CA44	A0A341AXW8	Autophagy protein 5; Involved in autophagic vesicle formation.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.461
AZI2	CHUK	A0A341C1A2	A0A341AMA5	5-azacytidine-induced protein 2.	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1.	0.644
AZI2	IKBKB	A0A341C1A2	A0A341D197	5-azacytidine-induced protein 2.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.644