(89 nodes) Th1 and Th2 cell differentiation network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MAF	LOW QUALITY PROTEIN: transcription factor Maf; Belongs to the bZIP family. (323 aa)
	DLL3	Delta-like protein 3. (587 aa)
	NFKBIB	NF-kappa-B inhibitor beta. (353 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	IL12RB1	Interleukin-12 receptor subunit beta-1 isoform X1. (762 aa)
	LOC112414040	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	NOTCH3	Neurogenic locus notch homolog protein 3. (2320 aa)
	LOC112413938	HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family. (260 aa)
	RUNX3	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (433 aa)
	LCK	Tyrosine-protein kinase. (509 aa)
	NFKBIE	NF-kappa-B inhibitor epsilon isoform X1. (428 aa)
	LOC112414069	HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
	MAPK13	Mitogen-activated protein kinase. (366 aa)
	MAPK14	Mitogen-activated protein kinase. (360 aa)
	MAML1	LOW QUALITY PROTEIN: mastermind-like protein 1. (983 aa)
	MAPK9	Mitogen-activated protein kinase. (424 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
	NOTCH2	Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	MAPK1	Mitogen-activated protein kinase. (343 aa)
	NOTCH1	LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
	NFKBIA	NF-kappa-B inhibitor alpha. (324 aa)
	EYS	LOW QUALITY PROTEIN: protein eyes shut homolog. (3129 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (600 aa)
	JAG2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1064 aa)
	IFNGR1	Interferon gamma receptor 1 isoform X1. (468 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (364 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	LOC112408477	Uncharacterized protein LOC112408477. (247 aa)
	JUN	LOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
	LOC112406848	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC112406849	boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1. (276 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	CD3G	T-cell surface glycoprotein CD3 gamma chain. (178 aa)
	CD3D	T-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
	CD3E	T-cell surface glycoprotein CD3 epsilon chain. (195 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
	RELA	Transcription factor p65. (562 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (549 aa)
	IL13	Interleukin-13. (145 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
	IKBKG	NF-kappa-B essential modulator isoform X1. (498 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1214 aa)
	RBPJL	Recombining binding protein suppressor of hairless-like protein. (516 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
	LOC112400027	Recombining binding protein suppressor of hairless isoform X1. (487 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (832 aa)
	LOC112399174	Signal transducer and activator of transcription. (618 aa)
	MAPK3	Mitogen-activated protein kinase 3. (265 aa)
	TBX21	T-box transcription factor TBX21. (501 aa)
	LAT	Linker for activation of T-cells family member 1 isoform X1. (260 aa)
	STAT5A	Signal transducer and activator of transcription. (726 aa)
	LOC112398972	Tyrosine-protein kinase. (612 aa)
	PLCG1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
	CD247	T-cell surface glycoprotein CD3 zeta chain. (165 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (480 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)
	MAPK11	Mitogen-activated protein kinase. (376 aa)
	FOS	Proto-oncogene c-Fos. (380 aa)
	MAPK12	Mitogen-activated protein kinase. (424 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	MAML3	Mastermind-like protein 3. (899 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (511 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2 isoform X1. (859 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
	PPP3R2	LOW QUALITY PROTEIN: calcineurin subunit B type 2. (229 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	LOC112392034	Signal transducer and activator of transcription 5A-like. (105 aa)
	NFATC3	Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
	CD4	T-cell surface glycoprotein CD4. (455 aa)
	IL2RA	Interleukin-2 receptor subunit alpha. (275 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	MAML2	Mastermind-like protein 2 isoform X1. (1117 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	DMA	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
	DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
	Neas-DQA	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
	Neas-DOB	HLA class II histocompatibility antigen, DO beta chain. (273 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD247	CD3D	A0A341B5Y6	A0A341BY90	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 delta chain isoform X1.	0.996
CD247	CD3E	A0A341B5Y6	A0A341BY51	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 epsilon chain.	0.999
CD247	CD3G	A0A341B5Y6	A0A341BZQ1	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD3 gamma chain.	0.999
CD247	CD4	A0A341B5Y6	A0A341AHR6	T-cell surface glycoprotein CD3 zeta chain.	T-cell surface glycoprotein CD4.	0.486
CD247	DMA	A0A341B5Y6	A0A0U2GPM3	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	0.796
CD247	DRA	A0A341B5Y6	A0A0U2GPH7	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.865
CD247	IL2RB	A0A341B5Y6	A0A341CRR8	T-cell surface glycoprotein CD3 zeta chain.	Interleukin-2 receptor subunit beta.	0.791
CD247	JAK1	A0A341B5Y6	A0A341D0I0	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.467
CD247	JAK2	A0A341B5Y6	A0A341AKB6	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.474
CD247	JAK3	A0A341B5Y6	A0A341D8D9	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.509
CD247	LAT	A0A341B5Y6	A0A341BBD9	T-cell surface glycoprotein CD3 zeta chain.	Linker for activation of T-cells family member 1 isoform X1.	0.688
CD247	LCK	A0A341B5Y6	A0A341D621	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.878
CD247	LOC112398972	A0A341B5Y6	A0A341BA78	T-cell surface glycoprotein CD3 zeta chain.	Tyrosine-protein kinase.	0.998
CD247	LOC112406848	A0A341B5Y6	A0A341CA33	T-cell surface glycoprotein CD3 zeta chain.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.860
CD247	LOC112406849	A0A341B5Y6	A0A341CA17	T-cell surface glycoprotein CD3 zeta chain.	boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1.	0.854
CD247	LOC112408477	A0A341B5Y6	A0A341CGW1	T-cell surface glycoprotein CD3 zeta chain.	Uncharacterized protein LOC112408477.	0.758
CD247	LOC112413938	A0A341B5Y6	A0A341D7D8	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family.	0.796
CD247	LOC112414040	A0A341B5Y6	A0A341D7V7	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.858
CD247	LOC112414069	A0A341B5Y6	A0A341D5D9	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DM beta chain isoform X1.	0.846
CD247	Neas-DOB	A0A341B5Y6	A0A0R9CVE8	T-cell surface glycoprotein CD3 zeta chain.	HLA class II histocompatibility antigen, DO beta chain.	0.855