STRINGSTRING
DMA DMA NFKBIB NFKBIB TGFB1 TGFB1 JAK3 JAK3 IL27RA IL27RA IL12RB1 IL12RB1 LOC112414040 LOC112414040 AHR AHR LOC112413938 LOC112413938 LCK LCK NFKBIE NFKBIE LOC112414069 LOC112414069 IRF4 IRF4 IL6ST IL6ST IL17A IL17A IL17F IL17F HSP90AB1 HSP90AB1 MAPK13 MAPK13 RXRB RXRB MAPK14 MAPK14 MAPK9 MAPK9 IKBKB IKBKB JAK1 JAK1 MAPK10 MAPK10 MAPK1 MAPK1 RORC RORC RXRA RXRA NFKBIA NFKBIA IL2RB IL2RB HSP90AA1 HSP90AA1 IFNGR1 IFNGR1 RUNX1 RUNX1 IFNGR2 IFNGR2 IL2RG IL2RG LOC112408477 LOC112408477 SMAD4 SMAD4 SMAD2 SMAD2 JUN JUN LOC112406848 LOC112406848 LOC112406849 LOC112406849 NFATC1 NFATC1 CD3G CD3G CD3D CD3D CD3E CD3E NFATC2 NFATC2 MTOR MTOR RELA RELA HIF1A HIF1A PPP3CC PPP3CC IL6R IL6R IL4 IL4 IKBKG IKBKG TYK2 TYK2 IL2 IL2 FOXP3 FOXP3 IL21 IL21 IL4R IL4R STAT3 STAT3 LOC112399174 LOC112399174 IL1R1 IL1R1 MAPK3 MAPK3 TGFBR2 TGFBR2 TBX21 TBX21 LAT LAT DUSP15 DUSP15 IL21R IL21R STAT5A STAT5A IL1B IL1B LOC112398972 LOC112398972 PLCG1 PLCG1 RARA RARA LOC112398563 LOC112398563 FOXS1 FOXS1 CD247 CD247 RXRG RXRG IL1RAP IL1RAP PPP3CB PPP3CB MAPK8 MAPK8 IL6 IL6 MAPK11 MAPK11 FOS FOS IL22 IL22 MAPK12 MAPK12 IL23A IL23A STAT6 STAT6 PPP3CA PPP3CA IFNG IFNG RORA RORA CHUK CHUK NFKB1 NFKB1 PPP3R2 PPP3R2 TGFBR1 TGFBR1 JAK2 JAK2 SMAD3 SMAD3 LOC112392034 LOC112392034 NFATC3 NFATC3 IL23R IL23R CD4 CD4 IL2RA IL2RA STAT1 STAT1 GATA3 GATA3 PRKCQ PRKCQ DRA DRA Neas-DQA Neas-DQA Neas-DOB Neas-DOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DMAHLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
NFKBIBNF-kappa-B inhibitor beta. (353 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
JAK3Tyrosine-protein kinase. (1104 aa)
IL27RAInterleukin-27 receptor subunit alpha isoform X1. (656 aa)
IL12RB1Interleukin-12 receptor subunit beta-1 isoform X1. (762 aa)
LOC112414040HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
AHRAryl hydrocarbon receptor. (845 aa)
LOC112413938HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family. (260 aa)
LCKTyrosine-protein kinase. (509 aa)
NFKBIENF-kappa-B inhibitor epsilon isoform X1. (428 aa)
LOC112414069HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
IRF4Interferon regulatory factor 4. (452 aa)
IL6STInterleukin-6 receptor subunit beta. (918 aa)
IL17Ainterleukin-17A isoform X1. (155 aa)
IL17Finterleukin-17F. (165 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (442 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
RORCNuclear receptor ROR-gamma isoform X1. (544 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
NFKBIANF-kappa-B inhibitor alpha. (324 aa)
IL2RBInterleukin-2 receptor subunit beta. (600 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
IFNGR1Interferon gamma receptor 1 isoform X1. (468 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
IFNGR2Interferon gamma receptor 2 isoform X2. (364 aa)
IL2RGCytokine receptor common subunit gamma isoform X1. (381 aa)
LOC112408477Uncharacterized protein LOC112408477. (247 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
LOC112406848DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
LOC112406849boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1. (276 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (195 aa)
NFATC2Nuclear factor of activated T-cells, cytoplasmic 2 isoform X1. (943 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
RELATranscription factor p65. (562 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
PPP3CCSerine/threonine-protein phosphatase. (549 aa)
IL6RInterleukin-6 receptor subunit alpha. (465 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1214 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
FOXP3LOW QUALITY PROTEIN: forkhead box protein P3. (452 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X1. (832 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC112399174Signal transducer and activator of transcription. (618 aa)
IL1R1Interleukin-1 receptor type 1 isoform X1. (723 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
TBX21T-box transcription factor TBX21. (501 aa)
LATLinker for activation of T-cells family member 1 isoform X1. (260 aa)
DUSP15Dual specificity protein phosphatase 15; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (235 aa)
IL21RInterleukin-21 receptor. (537 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LOC112398972Tyrosine-protein kinase. (612 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
LOC112398563Interferon regulatory factor 4-like isoform X1. (406 aa)
FOXS1Forkhead box protein S1. (330 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (165 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
IL1RAPInterleukin-1 receptor accessory protein isoform X1. (685 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL6Interleukin-6. (208 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
FOSProto-oncogene c-Fos. (380 aa)
IL22Interleukin-22. (189 aa)
MAPK12Mitogen-activated protein kinase. (424 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
STAT6Signal transducer and activator of transcription. (859 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RORANuclear receptor ROR-alpha. (386 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (229 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
LOC112392034Signal transducer and activator of transcription 5A-like. (105 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1073 aa)
IL23RInterleukin-23 receptor. (630 aa)
CD4T-cell surface glycoprotein CD4. (455 aa)
IL2RAInterleukin-2 receptor subunit alpha. (275 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
DRAHLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
Neas-DQAHLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
Neas-DOBHLA class II histocompatibility antigen, DO beta chain. (273 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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