STRINGSTRING
AKT2 AKT2 ERAS ERAS ATF2 ATF2 FKBP4 FKBP4 SOS2 SOS2 HSP90B1 HSP90B1 LOC112392089 LOC112392089 KRAS KRAS PLCB2 PLCB2 SHC3 SHC3 LOC112392004 LOC112392004 ITPR2 ITPR2 LOC112392009 LOC112392009 LOC112392016 LOC112392016 MAP2K1 MAP2K1 GABBR2 GABBR2 KCNJ3 KCNJ3 KRT18 KRT18 CALM1 CALM1 SP1 SP1 ADCY6 ADCY6 MMP20 MMP20 CREB1 CREB1 GNAI2 GNAI2 LOC112395427 LOC112395427 GNAI1 GNAI1 FOS FOS ATF4 ATF4 LOC112395611 LOC112395611 ATF6B ATF6B NCOA2 NCOA2 HSPA8 HSPA8 EBAG9 EBAG9 SHC2 SHC2 CREB3L2 CREB3L2 ADCY8 ADCY8 KCNJ5 KCNJ5 GNAI3 GNAI3 LOC112397943 LOC112397943 LOC112397950 LOC112397950 KRT36 KRT36 RARA RARA LOC112398655 LOC112398655 KRT15 KRT15 LOC112398582 LOC112398582 LOC112398445 LOC112398445 LOC112398455 LOC112398455 SRC SRC KRT24 KRT24 LOC112398440 LOC112398440 LOC112398674 LOC112398674 LOC112399209 LOC112399209 MAPK3 MAPK3 LOC112399192 LOC112399192 LOC112399197 LOC112399197 CREB3L3 CREB3L3 LOC112400438 LOC112400438 PRKCD PRKCD NCOA3 NCOA3 ADCY1 ADCY1 MAP2K2 MAP2K2 MMP2 MMP2 ADCY7 ADCY7 MMP9 MMP9 GRM1 GRM1 ITPR1 ITPR1 LOC112400993 LOC112400993 OPRM1 OPRM1 SHC1 SHC1 CREB3L4 CREB3L4 ESR1 ESR1 CCDC170 CCDC170 CTSD CTSD LOC112402235 LOC112402235 HRAS HRAS CEP152 CEP152 SHC4 SHC4 PLCB3 PLCB3 CREB3L1 CREB3L1 LOC112402955 LOC112402955 PIK3CD PIK3CD LOC112403184 LOC112403184 LOC112402987 LOC112402987 ESR2 ESR2 PIK3CB PIK3CB LOC112403409 LOC112403409 KCNJ9 KCNJ9 GNAO1 GNAO1 HSPA2 HSPA2 HSPA6 HSPA6 HBEGF HBEGF PIK3R1 PIK3R1 ADCY2 ADCY2 SOS1 SOS1 CALM2 CALM2 ADCY4 ADCY4 AKT3 AKT3 NOS3 NOS3 CREB5 CREB5 BCL2 BCL2 PIK3CA PIK3CA JUN JUN TGFA TGFA RAF1 RAF1 LOC112407344 LOC112407344 LOC112407559 LOC112407559 ADCY5 ADCY5 LOC112407558 LOC112407558 AKT1 AKT1 KCNJ6 KCNJ6 ADCY9 ADCY9 HSP90AA1 HSP90AA1 PVALEF PVALEF CALML6 CALML6 PGR PGR CALML4 CALML4 GRB2 GRB2 CREB3 CREB3 GPER1 GPER1 MAPK1 MAPK1 PLCB1 PLCB1 NCOA1 NCOA1 POMC POMC ADCY3 ADCY3 GABBR1 GABBR1 CSDE1 CSDE1 NRAS NRAS PLCB4 PLCB4 EGFR EGFR PTRHD1 PTRHD1 HSP90AB1 HSP90AB1 ITPR3 ITPR3 FKBP5 FKBP5 PIK3R2 PIK3R2 PRKACA PRKACA PRKACB PRKACB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERASGTPase ERas. (225 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
FKBP4Peptidylprolyl isomerase. (458 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
HSP90B1Endoplasmin. (805 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
KRASGTPase KRas isoform X3. (227 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
SHC3SHC-transforming protein 3. (470 aa)
LOC112392004Heat shock 70 kDa protein 1B-like. (124 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
LOC112392009Heat shock 70 kDa protein. (156 aa)
LOC112392016Heat shock 70 kDa protein 1B. (174 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GABBR2Gamma-aminobutyric acid type B receptor subunit 2. (883 aa)
KCNJ3G protein-activated inward rectifier potassium channel 1. (501 aa)
KRT18Keratin, type I cytoskeletal 18; Belongs to the intermediate filament family. (429 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
SP1Transcription factor Sp1. (780 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
LOC112395427Heat shock 70 kDa protein 1-like; Belongs to the heat shock protein 70 family. (641 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
FOSProto-oncogene c-Fos. (380 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
LOC112395611Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (702 aa)
NCOA2Nuclear receptor coactivator. (1464 aa)
HSPA8Heat shock cognate 71 kDa protein; Belongs to the heat shock protein 70 family. (650 aa)
EBAG9Receptor-binding cancer antigen expressed on SiSo cells isoform X1. (336 aa)
SHC2SHC-transforming protein 2. (426 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1249 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
LOC112397943Keratin, type I microfibrillar 48 kDa, component 8C-1-like; Belongs to the intermediate filament family. (416 aa)
LOC112397950Keratin, type I cytoskeletal 12-like isoform X1; Belongs to the intermediate filament family. (484 aa)
KRT36Keratin, type I cuticular Ha6; Belongs to the intermediate filament family. (459 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
LOC112398655LOW QUALITY PROTEIN: keratin, type I cytoskeletal 42-like; Belongs to the intermediate filament family. (395 aa)
KRT15Keratin, type I cytoskeletal 15; Belongs to the intermediate filament family. (443 aa)
LOC112398582Keratin, type I cytoskeletal 13-like; Belongs to the intermediate filament family. (416 aa)
LOC112398445Keratin, type I cytoskeletal 17-like isoform X1; Belongs to the intermediate filament family. (449 aa)
LOC112398455LOW QUALITY PROTEIN: keratin, type I cytoskeletal 16-like; Belongs to the intermediate filament family. (408 aa)
SRCTyrosine-protein kinase. (601 aa)
KRT24LOW QUALITY PROTEIN: keratin, type I cytoskeletal 24; Belongs to the intermediate filament family. (499 aa)
LOC112398440Keratin, type I cytoskeletal 14-like; Belongs to the intermediate filament family. (474 aa)
LOC112398674Keratin, type I cytoskeletal 19; Belongs to the intermediate filament family. (400 aa)
LOC112399209Keratin, type I cytoskeletal 26-like; Belongs to the intermediate filament family. (255 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
LOC112399192LOW QUALITY PROTEIN: keratin, type I cuticular Ha5-like; Belongs to the intermediate filament family. (445 aa)
LOC112399197LOW QUALITY PROTEIN: keratin, type I cuticular Ha2-like; Belongs to the intermediate filament family. (475 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
NCOA3Nuclear receptor coactivator. (1400 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
MMP272 kDa type IV collagenase. (661 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1194 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
LOC112400993Calmodulin-like; Belongs to the calmodulin family. (149 aa)
OPRM1Mu-type opioid receptor isoform X3; Belongs to the G-protein coupled receptor 1 family. (403 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ESR1Estrogen receptor. (604 aa)
CCDC170LOW QUALITY PROTEIN: coiled-coil domain-containing protein 170. (730 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (411 aa)
LOC112402235Interferon-induced transmembrane protein 3-like. (146 aa)
HRASGTPase HRas isoform X1. (189 aa)
CEP152Centrosomal protein of 152 kDa. (1724 aa)
SHC4SHC-transforming protein 4 isoform X1. (630 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC112402955Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (946 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
LOC112403184Peptidylprolyl isomerase. (647 aa)
LOC112402987Neuroendocrine secretory protein 55-like. (241 aa)
ESR2Estrogen receptor beta isoform X1. (527 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC112403409LOW QUALITY PROTEIN: restin homolog. (543 aa)
KCNJ9G protein-activated inward rectifier potassium channel 3. (393 aa)
GNAO1LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(O) subunit alpha. (363 aa)
HSPA2Heat shock-related 70 kDa protein 2; Belongs to the heat shock protein 70 family. (638 aa)
HSPA6LOW QUALITY PROTEIN: heat shock 70 kDa protein 6; Belongs to the heat shock protein 70 family. (645 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
CALM2Calmodulin-2; Belongs to the calmodulin family. (149 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (502 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC112407344Heat shock cognate 71 kDa protein-like. (299 aa)
LOC112407559Calmodulin-like protein 3; Belongs to the calmodulin family. (190 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
LOC112407558Calmodulin-like. (140 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
KCNJ6G protein-activated inward rectifier potassium channel 2. (514 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
PVALEFParvalbumin-like EF-hand-containing protein. (134 aa)
CALML6Calmodulin-like protein 6 isoform X1. (216 aa)
PGRProgesterone receptor. (888 aa)
CALML4Calmodulin-like protein 4 isoform X1. (150 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (371 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
POMCPro-opiomelanocortin. (260 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
GABBR1Gamma-aminobutyric acid type B receptor subunit 1 isoform X1. (872 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NRASGTPase NRas. (189 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
FKBP5Peptidylprolyl isomerase. (457 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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