STRINGSTRING
PLCB2 PLCB2 ARSI ARSI LOC112390379 LOC112390379 PRKACB PRKACB ADCY8 ADCY8 KCNK9 KCNK9 KCNJ5 KCNJ5 PRKCG PRKCG ATP1B1 ATP1B1 CACNA1G CACNA1G CAMK4 CAMK4 PRKCB PRKCB DAGLB DAGLB CAMK2D CAMK2D CREB3L3 CREB3L3 CACNA1F CACNA1F ADCY1 ADCY1 CACNA1D CACNA1D LDLR LDLR ADCY7 ADCY7 ITPR1 ITPR1 LOC112400993 LOC112400993 CAMK2B CAMK2B NPR1 NPR1 CREB3L4 CREB3L4 ATP1B2 ATP1B2 DAGLA DAGLA NPPA NPPA PLCB3 PLCB3 CREB3L1 CREB3L1 CACNA1S CACNA1S LOC112402955 LOC112402955 LOC112403052 LOC112403052 LOC112402987 LOC112402987 CAMK1G CAMK1G ATP1A2 ATP1A2 ATP2B4 ATP2B4 PDE2A PDE2A ADCY2 ADCY2 CALM2 CALM2 PRKCE PRKCE ADCY4 ADCY4 PRKD3 PRKD3 ATP2B1 ATP2B1 CREB5 CREB5 PRKD1 PRKD1 ATP2B3 ATP2B3 LOC112407559 LOC112407559 ADCY5 ADCY5 LOC112407558 LOC112407558 SCARB1 SCARB1 ORAI1 ORAI1 ADCY9 ADCY9 CACNA1H CACNA1H PVALEF PVALEF CALML6 CALML6 PRKCA PRKCA CALML4 CALML4 LOC112410931 LOC112410931 CREB3 CREB3 PLCB1 PLCB1 KCNK3 KCNK3 POMC POMC ADCY3 ADCY3 CAMK1 CAMK1 LOC112413050 LOC112413050 MC2R MC2R PLCB4 PLCB4 STAR STAR PTRHD1 PTRHD1 AGT AGT ATP1A1 ATP1A1 ITPR3 ITPR3 PRKACA PRKACA PRKD2 PRKD2 CREB3L2 CREB3L2 ATP1B3 ATP1B3 LIPE LIPE ATP1A3 ATP1A3 AGTR1 AGTR1 GNA11 GNA11 CAMK2G CAMK2G ATP2B2 ATP2B2 ATF6B ATF6B LOC112395611 LOC112395611 ATF4 ATF4 ATP1B4 ATP1B4 LOC112395389 LOC112395389 CREB1 CREB1 ATF1 ATF1 ADCY6 ADCY6 CACNA1I CACNA1I CALM1 CALM1 NR4A1 NR4A1 NR4A2 NR4A2 CAMK1D CAMK1D ITPR2 ITPR2 ATF2 ATF2 CACNA1C CACNA1C CAMK2A CAMK2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
ARSIArylsulfatase I. (573 aa)
LOC112390379Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (276 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1249 aa)
KCNK9Potassium channel subfamily K member. (374 aa)
KCNJ5G protein-activated inward rectifier potassium channel 4. (419 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV isoform X1. (529 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
DAGLBSn1-specific diacylglycerol lipase beta isoform X1. (669 aa)
CAMK2DCalcium/calmodulin-dependent protein kinase type II subunit delta; Belongs to the protein kinase superfamily. (449 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1910 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
LDLRLow-density lipoprotein receptor isoform X1. (857 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
LOC112400993Calmodulin-like; Belongs to the calmodulin family. (149 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta. (808 aa)
NPR1Guanylate cyclase. (1059 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (296 aa)
DAGLASn1-specific diacylglycerol lipase alpha isoform X1. (1040 aa)
NPPANatriuretic peptides A. (152 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1866 aa)
LOC112402955Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (946 aa)
LOC112403052Sodium/potassium-transporting ATPase subunit alpha. (1037 aa)
LOC112402987Neuroendocrine secretory protein 55-like. (241 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G; Belongs to the protein kinase superfamily. (476 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
PDE2APhosphodiesterase. (964 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
CALM2Calmodulin-2; Belongs to the calmodulin family. (149 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
PRKD3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (890 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (502 aa)
PRKD1Serine/threonine-protein kinase D1 isoform X1. (796 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1167 aa)
LOC112407559Calmodulin-like protein 3; Belongs to the calmodulin family. (190 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
LOC112407558Calmodulin-like. (140 aa)
SCARB1Scavenger receptor class B member 1 isoform X1; Belongs to the CD36 family. (511 aa)
ORAI1LOW QUALITY PROTEIN: calcium release-activated calcium channel protein 1. (410 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
CACNA1HVoltage-dependent T-type calcium channel subunit alpha-1H. (2239 aa)
PVALEFParvalbumin-like EF-hand-containing protein. (134 aa)
CALML6Calmodulin-like protein 6 isoform X1. (216 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
CALML4Calmodulin-like protein 4 isoform X1. (150 aa)
LOC112410931Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (520 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (371 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
KCNK3Potassium channel subfamily K member. (355 aa)
POMCPro-opiomelanocortin. (260 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1 isoform X1; Belongs to the protein kinase superfamily. (387 aa)
LOC1124130503 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; Belongs to the 3-beta-HSD family. (373 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
STARSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (336 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
PRKD2LOW QUALITY PROTEIN: serine/threonine-protein kinase D2. (806 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (279 aa)
LIPEHormone-sensitive lipase isoform X1. (799 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (941 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (337 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1. (507 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1320 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (702 aa)
LOC112395611Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (356 aa)
LOC112395389Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (403 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
ATF1Cyclic AMP-dependent transcription factor ATF-1 isoform X1. (336 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (1935 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (593 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
CAMK1DCalcium/calmodulin-dependent protein kinase type 1D; Belongs to the protein kinase superfamily. (385 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2111 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha; Belongs to the protein kinase superfamily. (478 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (16%) [HD]