STRINGSTRING
RXRG RXRG PRKCG PRKCG MMP14 MMP14 BRAF BRAF MAFB MAFB MMP24 MMP24 MAPK3 MAPK3 PRKCB PRKCB SLC34A1 SLC34A1 SLC34A2 SLC34A2 CREB3L3 CREB3L3 PDE4A PDE4A ADCY1 ADCY1 MMP15 MMP15 GCM2 GCM2 ADCY7 ADCY7 ITPR1 ITPR1 BGLAP BGLAP CREB3L4 CREB3L4 ARHGEF11 ARHGEF11 AKAP13 AKAP13 MEF2D MEF2D LRP5 LRP5 PLCB3 PLCB3 CREB3L1 CREB3L1 LOC112402955 LOC112402955 ARAF ARAF LOC112402987 LOC112402987 LOC112403033 LOC112403033 PTH1R PTH1R EGR1 EGR1 LOC112404727 LOC112404727 HBEGF HBEGF ADCY2 ADCY2 ADCY4 ADCY4 CREB5 CREB5 BCL2 BCL2 TNFSF11 TNFSF11 KL KL GCM1 GCM1 ARR3 ARR3 RAF1 RAF1 ADCY5 ADCY5 PTH PTH LOC112408488 LOC112408488 TRPV5 TRPV5 MMP25 MMP25 ADCY9 ADCY9 GNA13 GNA13 PRKCA PRKCA SOST SOST SLC9A3R1 SLC9A3R1 SLC34A3 SLC34A3 RXRA RXRA ARRB1 ARRB1 CREB3 CREB3 MAPK1 MAPK1 PLCB1 PLCB1 GNA12 GNA12 ADCY3 ADCY3 FGFR1 FGFR1 PLCB4 PLCB4 EGFR EGFR PTRHD1 PTRHD1 PDE4B PDE4B RUNX2 RUNX2 RXRB RXRB ITPR3 ITPR3 CDKN1A CDKN1A PDE4D PDE4D PDE4C PDE4C ARHGEF1 ARHGEF1 PRKACA PRKACA JUND JUND PRKACB PRKACB MMP13 MMP13 CASR CASR ADCY8 ADCY8 CREB3L2 CREB3L2 MMP17 MMP17 LOC112396244 LOC112396244 GNA11 GNA11 ATF6B ATF6B LOC112395611 LOC112395611 ATF4 ATF4 FOS FOS GNAI1 GNAI1 GNAI2 GNAI2 CREB1 CREB1 RHOA RHOA PLD2 PLD2 LOC112394343 LOC112394343 ADCY6 ADCY6 NACA NACA SP1 SP1 VDR VDR NR4A2 NR4A2 ARRB2 ARRB2 PLD1 PLD1 MAP2K1 MAP2K1 ITPR2 ITPR2 LRP6 LRP6 LOC112392060 LOC112392060 ATF2 ATF2 MEF2C MEF2C FGF23 FGF23 PTHLH PTHLH LOC112392076 LOC112392076 MEF2A MEF2A MMP16 MMP16 PLCB2 PLCB2 GATA3 GATA3 GNAI3 GNAI3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
MMP14Matrix metalloproteinase-14. (582 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
MAFBTranscription factor MafB. (323 aa)
MMP24Matrix metalloproteinase-24. (532 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
SLC34A1Sodium-dependent phosphate transport protein 2A. (639 aa)
SLC34A2Sodium-dependent phosphate transport protein 2B. (698 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
PDE4APhosphodiesterase. (858 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
MMP15LOW QUALITY PROTEIN: matrix metalloproteinase-15. (662 aa)
GCM2Chorion-specific transcription factor GCMb. (551 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2709 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (148 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1570 aa)
AKAP13A-kinase anchor protein 13. (857 aa)
MEF2DMyocyte-specific enhancer factor 2D. (504 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
LOC112402955Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (946 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
LOC112402987Neuroendocrine secretory protein 55-like. (241 aa)
LOC1124030331,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (514 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (583 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
LOC112404727A-kinase anchor protein 13-like isoform X1. (1923 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1037 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (502 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
KLKlotho. (1074 aa)
GCM1Chorion-specific transcription factor GCMa. (434 aa)
ARR3arrestin-C. (393 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1204 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (692 aa)
MMP25Matrix metalloproteinase-25 isoform X1. (552 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13. (282 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
SOSTSclerostin. (212 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
SLC34A3Sodium-dependent phosphate transport protein 2C. (602 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
ARRB1Beta-arrestin-1 isoform X1. (418 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (371 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12. (305 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PDE4BPhosphodiesterase. (736 aa)
RUNX2Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (408 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (442 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2670 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PDE4DPhosphodiesterase. (747 aa)
PDE4CPhosphodiesterase. (697 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (977 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
JUNDTranscription factor jun-D. (345 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
MMP13Collagenase 3. (471 aa)
CASRExtracellular calcium-sensing receptor. (1077 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1249 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
MMP17Matrix metalloproteinase-17. (511 aa)
LOC112396244Matrix metalloproteinase-17-like. (232 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (337 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (702 aa)
LOC112395611Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
FOSProto-oncogene c-Fos. (380 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RHOATransforming protein RhoA. (193 aa)
PLD2Phospholipase. (933 aa)
LOC11239434325-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Belongs to the cytochrome P450 family. (508 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
NACANascent polypeptide-associated complex subunit alpha isoform X1. (219 aa)
SP1Transcription factor Sp1. (780 aa)
VDRVitamin D3 receptor. (427 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
ARRB2Beta-arrestin-2. (409 aa)
PLD1Phospholipase. (1151 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2 isoform X1. (2701 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X4. (483 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (212 aa)
PTHLHParathyroid hormone-related protein. (177 aa)
LOC112392076A-kinase anchor protein 13-like. (107 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (501 aa)
MMP16Matrix metalloproteinase-16. (607 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (16%) [HD]