STRINGSTRING
ADIPOQ ADIPOQ PIK3R1 PIK3R1 HK2 HK2 LOC112403425 LOC112403425 PIK3CB PIK3CB PIK3CD PIK3CD INS INS MTOR MTOR IRS4 IRS4 GCK GCK PKLR PKLR CACNA1D CACNA1D INSR INSR LOC112399963 LOC112399963 PRKCD PRKCD LOC112400438 LOC112400438 MAPK3 MAPK3 SOCS1 SOCS1 CACNA1G CACNA1G HK3 HK3 MAFA MAFA IRS1 IRS1 PARP8 PARP8 TNF TNF MAPK8 MAPK8 SOCS4 SOCS4 SLC2A2 SLC2A2 TNIK TNIK CACNA1C CACNA1C ABCC8 ABCC8 KCNJ11 KCNJ11 SLC2A4 SLC2A4 CACNA1B CACNA1B MAPK1 MAPK1 MAPK10 MAPK10 IKBKB IKBKB MAPK9 MAPK9 HKDC1 HKDC1 HK1 HK1 CACNA1A CACNA1A PIK3R2 PIK3R2 PARP6 PARP6 PKM PKM SOCS3 SOCS3 PRKCZ PRKCZ CACNA1E CACNA1E PIK3CA PIK3CA PDX1 PDX1 IRS2 IRS2 SOCS2 SOCS2 PRKCE PRKCE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADIPOQAdiponectin. (243 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HK2Hexokinase-2. (917 aa)
LOC112403425Protein kinase C zeta type-like. (85 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
IRS4LOW QUALITY PROTEIN: insulin receptor substrate 4. (1261 aa)
GCKPhosphotransferase. (537 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2183 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LOC112399963LOW QUALITY PROTEIN: insulin receptor substrate 1-like. (561 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
SOCS1Suppressor of cytokine signaling 1. (214 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2382 aa)
HK3Hexokinase-3 isoform X1. (989 aa)
MAFATranscription factor MafA. (230 aa)
IRS1Insulin receptor substrate 1. (1248 aa)
PARP8Poly [ADP-ribose] polymerase. (929 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SOCS4Suppressor of cytokine signaling 4. (440 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
TNIKTRAF2 and NCK-interacting protein kinase isoform X1. (1331 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2111 aa)
ABCC8ATP-binding cassette sub-family C member 8 isoform X1. (1608 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11. (388 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (603 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (1986 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2284 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
SOCS3Suppressor of cytokine signaling 3. (237 aa)
PRKCZLOW QUALITY PROTEIN: protein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (546 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2314 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDX1Pancreas/duodenum homeobox protein 1. (289 aa)
IRS2Insulin receptor substrate 2. (702 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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