STRINGSTRING
VEGFC VEGFC PLCB2 PLCB2 KRAS KRAS CDKN1B CDKN1B COL3A1 COL3A1 LOC112392089 LOC112392089 STAT1 STAT1 LOC112392034 LOC112392034 SMAD3 SMAD3 JAK2 JAK2 TGFBR1 TGFBR1 PLCG2 PLCG2 NFKB1 NFKB1 LOC112394151 LOC112394151 MAPK12 MAPK12 CDK4 CDK4 MMP20 MMP20 AGER AGER TGFB3 TGFB3 MAPK11 MAPK11 IL6 IL6 MAPK8 MAPK8 TGFB2 TGFB2 PLCE1 PLCE1 TNF TNF MFF MFF COL4A4 COL4A4 COL4A3 COL4A3 SELE SELE PLCG1 PLCG1 IL1A IL1A IL1B IL1B STAT5A STAT5A TGFBR2 TGFBR2 MAPK3 MAPK3 PRKCB PRKCB VEGFD VEGFD LOC112399174 LOC112399174 STAT3 STAT3 COL1A1 COL1A1 RAC1 RAC1 SERPINE1 SERPINE1 ICAM1 ICAM1 LOC112400438 LOC112400438 PRKCD PRKCD MMP2 MMP2 NOX1 NOX1 NOX3 NOX3 VEGFB VEGFB COL4A6 COL4A6 HRAS HRAS COL4A5 COL4A5 CCND1 CCND1 RELA RELA PLCB3 PLCB3 PIK3CD PIK3CD THBD THBD PIK3CB PIK3CB LOC112403425 LOC112403425 F3 F3 VCAM1 VCAM1 EGR1 EGR1 DIAPH1 DIAPH1 PIK3R1 PIK3R1 PRKCE PRKCE COL4A2 COL4A2 COL4A1 COL4A1 CXCL8 CXCL8 AKT3 AKT3 NOS3 NOS3 BCL2 BCL2 NFATC1 NFATC1 FOXO1 FOXO1 PIK3CA PIK3CA JUN JUN PLCD1 PLCD1 SMAD2 SMAD2 SMAD4 SMAD4 AKT1 AKT1 CASP3 CASP3 PRKCZ PRKCZ PLCD3 PLCD3 PRKCA PRKCA NOX4 NOX4 FN1 FN1 PLCD4 PLCD4 MAPK1 MAPK1 MAPK10 MAPK10 PLCB1 PLCB1 EDN1 EDN1 CSDE1 CSDE1 NRAS NRAS MAPK9 MAPK9 PLCB4 PLCB4 AGT AGT MAPK14 MAPK14 MAPK13 MAPK13 VEGFA VEGFA PIM1 PIM1 XK XK LOC112414233 LOC112414233 CDC42 CDC42 COL1A2 COL1A2 PIK3R2 PIK3R2 TGFB1 TGFB1 AGTR1 AGTR1 AKT2 AKT2 ERAS ERAS BAX BAX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (350 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
KRASGTPase KRas isoform X3. (227 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
COL3A1Collagen alpha-1(III) chain. (1463 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
LOC112392034Signal transducer and activator of transcription 5A-like. (105 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
LOC112394151C-C motif chemokine. (99 aa)
MAPK12Mitogen-activated protein kinase. (424 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
MMP20Matrix metalloproteinase-20. (483 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (513 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
IL6Interleukin-6. (208 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MFFMitochondrial fission factor isoform X1. (353 aa)
COL4A4Collagen alpha-4(IV) chain isoform X3. (1687 aa)
COL4A3Collagen alpha-3(IV) chain isoform X1. (1674 aa)
SELEE-selectin isoform X1. (552 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1179 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
LOC112399174Signal transducer and activator of transcription. (618 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
COL1A1Collagen alpha-1(I) chain. (1463 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (148 aa)
SERPINE1Plasminogen activator inhibitor 1 isoform X1; Belongs to the serpin family. (402 aa)
ICAM1Intercellular adhesion molecule 1. (536 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
MMP272 kDa type IV collagenase. (661 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (569 aa)
NOX3NADPH oxidase 3. (568 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (286 aa)
COL4A6Collagen alpha-6(IV) chain isoform X2. (1706 aa)
HRASGTPase HRas isoform X1. (189 aa)
COL4A5Collagen alpha-5(IV) chain. (1686 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
RELATranscription factor p65. (562 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
THBDThrombomodulin. (574 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
LOC112403425Protein kinase C zeta type-like. (85 aa)
F3Tissue factor. (297 aa)
VCAM1Vascular cell adhesion protein 1. (739 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
DIAPH1Protein diaphanous homolog 1 isoform X1. (1196 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
COL4A2Collagen alpha-2(IV) chain isoform X1. (1760 aa)
COL4A1Collagen alpha-1(IV) chain. (1730 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
FOXO1Forkhead box protein O1. (511 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
PLCD1Phosphoinositide phospholipase C. (715 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (307 aa)
PRKCZLOW QUALITY PROTEIN: protein kinase C zeta type; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (546 aa)
PLCD3Phosphoinositide phospholipase C. (832 aa)
PRKCANon-specific serine/threonine protein kinase. (541 aa)
NOX4NADPH oxidase 4 isoform X1. (530 aa)
FN1Fibronectin isoform X5. (2478 aa)
PLCD4Phosphoinositide phospholipase C. (822 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
EDN1Endothelin-1. (202 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NRASGTPase NRas. (189 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (349 aa)
XKXK-related protein. (444 aa)
LOC112414233Cytochrome b-245 heavy chain isoform X1. (570 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
COL1A2Collagen alpha-2(I) chain. (1366 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
AGTR1Type-1 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERASGTPase ERas. (225 aa)
BAXApoptosis regulator BAX. (192 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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