STRINGSTRING
LY96 LY96 LOC112407559 LOC112407559 NLRP10 NLRP10 CASP7 CASP7 LOC112407461 LOC112407461 CCDC125 CCDC125 JUN JUN IRAK1 IRAK1 NOD1 NOD1 IL12A IL12A NLRP3 NLRP3 LOC112405640 LOC112405640 CXCL8 CXCL8 CALM2 CALM2 CD14 CD14 TRAF6 TRAF6 C4BPA C4BPA C4BPB C4BPB LOC112403444 LOC112403444 IL10 IL10 SERPING1 SERPING1 RELA RELA CFL1 CFL1 IRF1 IRF1 LOC112400993 LOC112400993 C3 C3 TICAM1 TICAM1 LOC112400340 LOC112400340 LOC112399406 LOC112399406 ITGAM ITGAM MAPK3 MAPK3 TICAM2 TICAM2 TMED7 TMED7 LOC112399310 LOC112399310 IL1B IL1B IL1A IL1A TMED3 TMED3 GNAI3 GNAI3 IRAK4 IRAK4 TIRAP TIRAP LOC112396492 LOC112396492 TNF TNF LOC112407558 LOC112407558 ITGB2 ITGB2 C2 C2 LOC112395446 LOC112395446 MAPK8 MAPK8 IL6 IL6 MAPK11 MAPK11 FOS FOS GNAI1 GNAI1 GNAI2 GNAI2 RHOA RHOA NOS2 NOS2 MAPK12 MAPK12 IL23A IL23A CALM1 CALM1 IRF8 IRF8 ITGA5 ITGA5 NFKB1 NFKB1 C1RL C1RL C1R C1R C1S C1S CASP3 CASP3 PVALEF PVALEF CALML6 CALML6 CALML4 CALML4 EFCAB3 EFCAB3 CFL2 CFL2 C5 C5 TLR4 TLR4 MAPK1 MAPK1 MAPK10 MAPK10 MAPK9 MAPK9 MYD88 MYD88 MAPK14 MAPK14 MAPK13 MAPK13 ITGB1 ITGB1 C1QC C1QC C1QB C1QB C1QA C1QA IL12B IL12B IRF3 IRF3 CASP1 CASP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LY96Lymphocyte antigen 96. (160 aa)
LOC112407559Calmodulin-like protein 3; Belongs to the calmodulin family. (190 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (561 aa)
CASP7Caspase-7 isoform X1; Belongs to the peptidase C14A family. (301 aa)
LOC112407461LOW QUALITY PROTEIN: cofilin-1-like; Belongs to the actin-binding proteins ADF family. (238 aa)
CCDC125Coiled-coil domain-containing protein 125 isoform X1. (514 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (586 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1 isoform X1. (963 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
NLRP3NACHT, LRR and PYD domains-containing protein 3 isoform X1. (1035 aa)
LOC112405640C-X-C motif chemokine. (113 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
CALM2Calmodulin-2; Belongs to the calmodulin family. (149 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
C4BPAC4b-binding protein alpha chain isoform X1. (638 aa)
C4BPBC4b-binding protein beta chain. (255 aa)
LOC112403444Apolipoprotein R-like. (189 aa)
IL10Interleukin-10. (178 aa)
SERPING1Plasma protease C1 inhibitor isoform X1; Belongs to the serpin family. (484 aa)
RELATranscription factor p65. (562 aa)
CFL1Cofilin-1 isoform X1; Belongs to the actin-binding proteins ADF family. (166 aa)
IRF1Interferon regulatory factor. (322 aa)
LOC112400993Calmodulin-like; Belongs to the calmodulin family. (149 aa)
C3LOW QUALITY PROTEIN: complement C3. (1656 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
LOC112400340Complement C3-like. (1706 aa)
LOC112399406Apoptosis-associated speck-like protein containing a CARD isoform X1. (191 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1153 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TICAM2TIR domain-containing adapter molecule 2. (235 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (225 aa)
LOC112399310Apoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
TMED3Transmembrane emp24 domain-containing protein 3. (220 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
TIRAPToll/interleukin-1 receptor domain-containing adapter protein. (229 aa)
LOC112396492Pulmonary surfactant-associated protein A isoform X1. (248 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC112407558Calmodulin-like. (140 aa)
ITGB2Integrin beta. (770 aa)
C2Complement C2; Belongs to the peptidase S1 family. (751 aa)
LOC112395446Complement C4-like. (1739 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL6Interleukin-6. (208 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
FOSProto-oncogene c-Fos. (380 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
RHOATransforming protein RhoA. (193 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
MAPK12Mitogen-activated protein kinase. (424 aa)
IL23AInterleukin-23 subunit alpha. (189 aa)
CALM1Calmodulin-1; Belongs to the calmodulin family. (149 aa)
IRF8Interferon regulatory factor 8 isoform X1. (427 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
C1RLComplement C1r subcomponent-like protein isoform X1; Belongs to the peptidase S1 family. (534 aa)
C1RComplement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (713 aa)
C1SComplement C1s subcomponent; Belongs to the peptidase S1 family. (689 aa)
CASP3Caspase-3 isoform X1; Belongs to the peptidase C14A family. (307 aa)
PVALEFParvalbumin-like EF-hand-containing protein. (134 aa)
CALML6Calmodulin-like protein 6 isoform X1. (216 aa)
CALML4Calmodulin-like protein 4 isoform X1. (150 aa)
EFCAB3EF-hand calcium-binding domain-containing protein 3 isoform X1. (436 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (149 aa)
C5Complement C5. (1677 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
MYD88Myeloid differentiation primary response protein MyD88. (182 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
IRF3Interferon regulatory factor 3. (419 aa)
CASP1Caspase-1; Belongs to the peptidase C14A family. (404 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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