STRINGSTRING
GNA15 GNA15 GNA14 GNA14 LOC112395837 LOC112395837 GNA11 GNA11 IRAK4 IRAK4 GNAI3 GNAI3 CD247 CD247 IL1B IL1B TGFBR2 TGFBR2 FAS FAS MAPK3 MAPK3 PPP2CA PPP2CA SERPINE1 SERPINE1 LOC112400438 LOC112400438 IL2 IL2 LOC112400529 LOC112400529 TICAM1 TICAM1 ADCY1 ADCY1 C3 C3 IKBKG IKBKG RELA RELA PLCB3 PLCB3 LOC112402955 LOC112402955 FADD FADD PIK3CD PIK3CD LOC112402987 LOC112402987 PIK3CB PIK3CB IL10 IL10 GNAO1 GNAO1 CD3E CD3E CD3D CD3D CD3G CD3G TRAF6 TRAF6 PIK3R1 PIK3R1 MAP2K4 MAP2K4 CXCL8 CXCL8 AKT3 AKT3 PPP2R1B PPP2R1B IL12A IL12A PIK3CA PIK3CA IRAK1 IRAK1 JUN JUN IFNB1 IFNB1 SMAD2 SMAD2 CASP8 CASP8 CFLAR CFLAR MYD88 MYD88 TLR2 TLR2 LOC112408083 LOC112408083 AKT1 AKT1 LOC112408477 LOC112408477 IFNGR2 IFNGR2 LOC112408041 LOC112408041 CCL5 CCL5 LOC112408084 LOC112408084 IFNGR1 IFNGR1 BDKRB2 BDKRB2 LOC112410212 LOC112410212 LOC112410281 LOC112410281 IKBKB IKBKB PPP2R2A PPP2R2A PPP2R1A PPP2R1A TGFB1 TGFB1 IL12B IL12B CALR CALR C1QA C1QA PIK3R2 PIK3R2 C1QB C1QB MAPK13 MAPK13 MAPK14 MAPK14 PLCB4 PLCB4 MAPK9 MAPK9 LOC112410213 LOC112410213 PPP2R2D PPP2R2D NFKBIA NFKBIA TLR4 TLR4 MAPK1 MAPK1 MAPK10 MAPK10 PLCB1 PLCB1 GNAL GNAL PPP2CB PPP2CB C1QC C1QC AKT2 AKT2 KNG1 KNG1 PLCB2 PLCB2 PPP2R2B PPP2R2B TLR6 TLR6 FASLG FASLG LOC112392089 LOC112392089 TNFRSF1A TNFRSF1A TGFBR1 TGFBR1 NFKB1 NFKB1 CHUK CHUK IFNG IFNG LOC112394151 LOC112394151 PPP2R2C PPP2R2C MAPK12 MAPK12 NOS2 NOS2 GNAI2 GNAI2 GNAI1 GNAI1 TGFB3 TGFB3 FOS FOS MAPK11 MAPK11 LOC112395611 LOC112395611 IL6 IL6 MAPK8 MAPK8 TGFB2 TGFB2 TNF TNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
LOC112395837LOW QUALITY PROTEIN: calreticulin-like. (540 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (337 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CD247T-cell surface glycoprotein CD3 zeta chain. (165 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FASTumor necrosis factor receptor superfamily member 6 isoform X1. (334 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SERPINE1Plasminogen activator inhibitor 1 isoform X1; Belongs to the serpin family. (402 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
LOC112400529Toll-like receptor 9 isoform X4. (1323 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (699 aa)
ADCY1Adenylate cyclase type 1. (907 aa)
C3LOW QUALITY PROTEIN: complement C3. (1656 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
RELATranscription factor p65. (562 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1172 aa)
LOC112402955Guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas-like. (946 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
LOC112402987Neuroendocrine secretory protein 55-like. (241 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
IL10Interleukin-10. (178 aa)
GNAO1LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(O) subunit alpha. (363 aa)
CD3ET-cell surface glycoprotein CD3 epsilon chain. (195 aa)
CD3DT-cell surface glycoprotein CD3 delta chain isoform X1. (171 aa)
CD3GT-cell surface glycoprotein CD3 gamma chain. (178 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (362 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
PPP2R1BSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2. (696 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (586 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
IFNB1Interferon beta. (185 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (497 aa)
CFLARCASP8 and FADD-like apoptosis regulator isoform X1; Belongs to the peptidase C14A family. (532 aa)
MYD88Myeloid differentiation primary response protein MyD88. (182 aa)
TLR2Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
LOC112408083C-C motif chemokine. (90 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
LOC112408477Uncharacterized protein LOC112408477. (247 aa)
IFNGR2Interferon gamma receptor 2 isoform X2. (364 aa)
LOC112408041C-C motif chemokine. (95 aa)
CCL5C-C motif chemokine. (91 aa)
LOC112408084C-C motif chemokine 3-like. (87 aa)
IFNGR1Interferon gamma receptor 1 isoform X1. (468 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LOC112410212Angiotensin-converting enzyme. (752 aa)
LOC112410281annotation not available (287 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
PPP2R1ASerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform. (589 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
CALRCalreticulin. (417 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
C1QBComplement C1q subcomponent subunit B. (290 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
LOC112410213Angiotensin-converting enzyme. (1380 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
NFKBIANF-kappa-B inhibitor alpha. (324 aa)
TLR4Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (380 aa)
PPP2CBSerine/threonine-protein phosphatase. (244 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
KNG1Kininogen-1 isoform X1. (627 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1185 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
TLR6Toll-like receptor 6; Belongs to the Toll-like receptor family. (797 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (262 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC112394151C-C motif chemokine. (99 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
MAPK12Mitogen-activated protein kinase. (424 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (355 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1. (354 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
FOSProto-oncogene c-Fos. (380 aa)
MAPK11Mitogen-activated protein kinase. (376 aa)
LOC112395611Guanine nucleotide-binding protein G(Q) subunit alpha. (301 aa)
IL6Interleukin-6. (208 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (22%) [HD]