STRINGSTRING
SMAD3 SMAD3 STAT1 STAT1 LOC112392089 LOC112392089 TGFBR1 TGFBR1 PLD1 PLD1 NFKB1 NFKB1 CHUK CHUK GADD45A GADD45A CDK4 CDK4 PLD2 PLD2 TGFB3 TGFB3 MAPK8 MAPK8 BAX BAX AKT2 AKT2 LOC112415059 LOC112415059 TGFB1 TGFB1 E2F2 E2F2 PIK3R2 PIK3R2 CDK6 CDK6 CDC42 CDC42 BAK1 BAK1 CDKN1A CDKN1A VEGFA VEGFA EGFR EGFR MAPK9 MAPK9 IKBKB IKBKB JAK1 JAK1 MAPK10 MAPK10 POLK POLK RALBP1 RALBP1 MAPK1 MAPK1 RALGDS RALGDS RAC2 RAC2 RAC3 RAC3 ARHGEF6 ARHGEF6 RALB RALB LOC112408488 LOC112408488 AKT1 AKT1 RPS6KB1 RPS6KB1 SMAD4 SMAD4 SMAD2 SMAD2 LOC112407246 LOC112407246 RAF1 RAF1 TGFA TGFA RB1 RB1 PIK3CA PIK3CA BRCA2 BRCA2 AKT3 AKT3 PIK3R1 PIK3R1 RALA RALA PIK3CB PIK3CB ARAF ARAF PIK3CD PIK3CD MTOR MTOR BAD BAD CASP9 CASP9 RELA RELA CCND1 CCND1 DDB2 DDB2 RPS6KB2 RPS6KB2 TP53 TP53 IKBKG IKBKG LOC112400438 LOC112400438 RAC1 RAC1 STAT3 STAT3 MAPK3 MAPK3 TGFBR2 TGFBR2 BCL2L1 BCL2L1 E2F1 E2F1 ERBB2 ERBB2 BRAF BRAF EGF EGF E2F3 E2F3 GADD45B GADD45B TGFB2 TGFB2 RAD51 RAD51 MAP2K1 MAP2K1 KRAS KRAS GADD45G GADD45G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD3Mothers against decapentaplegic homolog. (376 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
PLD1Phospholipase. (1151 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
PLD2Phospholipase. (933 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAXApoptosis regulator BAX. (192 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC112415059Cyclin-dependent kinase inhibitor 2A-like. (109 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
CDC42Cell division control protein 42 homolog. (191 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (632 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
JAK1Tyrosine-protein kinase. (1153 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
POLKDNA polymerase kappa. (878 aa)
RALBP1ralA-binding protein 1. (635 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
RALGDSRal guanine nucleotide dissociation stimulator isoform X1. (853 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (197 aa)
RAC3Ras-related C3 botulinum toxin substrate 3. (221 aa)
ARHGEF6Rho guanine nucleotide exchange factor 6 isoform X4. (780 aa)
RALBRas-related protein Ral-B isoform X1. (242 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC112407246LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (156 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
RB1Retinoblastoma-associated protein. (816 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
RALARas-related protein Ral-A. (206 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
BADBcl2-associated agonist of cell death. (168 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (442 aa)
RELATranscription factor p65. (562 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (148 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
E2F1Transcription factor E2F1. (360 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
E2F3Transcription factor E2F3. (349 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
KRASGTPase KRas isoform X3. (227 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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