STRINGSTRING
RELA RELA IGF1 IGF1 KRAS KRAS IGF1R IGF1R CDKN1B CDKN1B SPINT1 SPINT1 LOC112392089 LOC112392089 HSP90B1 HSP90B1 PDGFRB PDGFRB SOS2 SOS2 LOC112392060 LOC112392060 CCNE1 CCNE1 LOC112392059 LOC112392059 MAP2K1 MAP2K1 NFKB1 NFKB1 CHUK CHUK NKX2-3 NKX2-3 LOC112394563 LOC112394563 CDK2 CDK2 MDM2 MDM2 CREB1 CREB1 EP300 EP300 ATF4 ATF4 E2F3 E2F3 CREB3L2 CREB3L2 PLAU PLAU LEF1 LEF1 EGF EGF BRAF BRAF ERBB2 ERBB2 E2F1 E2F1 IL1R2 IL1R2 MAPK3 MAPK3 TCF7L1 TCF7L1 PTEN PTEN TCF7 TCF7 CREB3L3 CREB3L3 PDGFC PDGFC LOC112400438 LOC112400438 PDGFRA PDGFRA MAP2K2 MAP2K2 IKBKG IKBKG NKX3-1 NKX3-1 MMP9 MMP9 INSRR INSRR SRD5A2 SRD5A2 CREB3L4 CREB3L4 LOC112402344 LOC112402344 TP53 TP53 HRAS HRAS CCND1 CCND1 CASP9 CASP9 CREB3L1 CREB3L1 BAD BAD MTOR MTOR LOC112402342 LOC112402342 INS INS PIK3CD PIK3CD ARAF ARAF PIK3CB PIK3CB ZEB1 ZEB1 AR AR PIK3R1 PIK3R1 SOS1 SOS1 AKT3 AKT3 CTNNB1 CTNNB1 CREB5 CREB5 BCL2 BCL2 FOXO1 FOXO1 LOC112406592 LOC112406592 PIK3CA PIK3CA FGFR2 FGFR2 TCF7L2 TCF7L2 RB1 RB1 TGFA TGFA RAF1 RAF1 LOC112407246 LOC112407246 CCNE2 CCNE2 AKT1 AKT1 LOC112408488 LOC112408488 TMPRSS2 TMPRSS2 ERG ERG PDPK1 PDPK1 CREBBP CREBBP HSP90AA1 HSP90AA1 PDGFB PDGFB GRB2 GRB2 NFKBIA NFKBIA CREB3 CREB3 PDGFA PDGFA MAPK1 MAPK1 CSDE1 CSDE1 NRAS NRAS IKBKB IKBKB FGFR1 FGFR1 EGFR EGFR PLAT PLAT HSP90AB1 HSP90AB1 CDKN1A CDKN1A PIK3R2 PIK3R2 E2F2 E2F2 ETV5 ETV5 LOC112415737 LOC112415737 PDGFD PDGFD GSK3B GSK3B AKT2 AKT2 ERAS ERAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RELATranscription factor p65. (562 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
KRASGTPase KRas isoform X3. (227 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
SPINT1Kunitz-type protease inhibitor 1. (510 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
HSP90B1Endoplasmin. (805 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
LOC112392059Stromelysin-1-like. (168 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
NKX2-3Homeobox protein Nkx-2.3. (363 aa)
LOC112394563Stromelysin-1-like. (242 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
EP300Histone acetyltransferase p300. (2399 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
E2F3Transcription factor E2F3. (349 aa)
CREB3L2Cyclic AMP-responsive element-binding protein 3-like protein 2. (520 aa)
PLAUUrokinase-type plasminogen activator. (431 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
E2F1Transcription factor E2F1. (360 aa)
IL1R2Interleukin-1 receptor type 2 isoform X1. (429 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (457 aa)
PDGFCPlatelet-derived growth factor C isoform X1. (314 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
NKX3-1Homeobox protein Nkx-3.1. (241 aa)
MMP9Matrix metalloproteinase-9. (709 aa)
INSRRTyrosine-protein kinase receptor. (1293 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (254 aa)
CREB3L4Cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1. (443 aa)
LOC112402344Glutathione S-transferase P; Belongs to the GST superfamily. (208 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
HRASGTPase HRas isoform X1. (189 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CASP9Caspase-9; Belongs to the peptidase C14A family. (442 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (520 aa)
BADBcl2-associated agonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
LOC112402342Glutathione S-transferase P-like isoform X1. (254 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ZEB1LOW QUALITY PROTEIN: zinc finger E-box-binding homeobox 1. (1042 aa)
ARAndrogen receptor isoform X1. (893 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
CTNNB1Catenin beta-1. (781 aa)
CREB5Cyclic AMP-responsive element-binding protein 5. (502 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
FOXO1Forkhead box protein O1. (511 aa)
LOC112406592Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
RB1Retinoblastoma-associated protein. (816 aa)
TGFAProtransforming growth factor alpha isoform X1. (290 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC112407246LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (156 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
TMPRSS2Transmembrane protease serine 2 isoform X1; Belongs to the peptidase S1 family. (528 aa)
ERGTranscriptional regulator ERG isoform X1. (486 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (531 aa)
CREBBPCREB-binding protein. (2443 aa)
HSP90AA1Heat shock protein HSP 90-alpha. (733 aa)
PDGFBPlatelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (209 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
NFKBIANF-kappa-B inhibitor alpha. (324 aa)
CREB3Cyclic AMP-responsive element-binding protein 3. (371 aa)
PDGFAPlatelet-derived growth factor subunit A isoform X1; Belongs to the PDGF/VEGF growth factor family. (211 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NRASGTPase NRas. (189 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (565 aa)
HSP90AB1Heat shock protein HSP 90-beta. (724 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
ETV5ETS translocation variant 5. (510 aa)
LOC112415737LOW QUALITY PROTEIN: macrophage metalloelastase-like. (209 aa)
PDGFDPlatelet-derived growth factor D isoform X1. (396 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERASGTPase ERas. (225 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.