STRINGSTRING
MAP2K1 MAP2K1 BAX BAX ERAS ERAS BAK1 BAK1 CDKN1A CDKN1A RXRB RXRB CCDC6 CCDC6 NRAS NRAS CSDE1 CSDE1 MAPK1 MAPK1 RXRA RXRA TFG TFG LOC112408488 LOC112408488 TCF7L2 TCF7L2 CTNNB1 CTNNB1 TPR TPR RET RET CCND1 CCND1 DDB2 DDB2 HRAS HRAS TP53 TP53 NTRK1 NTRK1 TPM3 TPM3 MAP2K2 MAP2K2 TCF7 TCF7 TCF7L1 TCF7L1 MAPK3 MAPK3 PAX8 PAX8 BRAF BRAF MYC MYC RXRG RXRG LEF1 LEF1 PPARG PPARG GADD45B GADD45B NCOA4 NCOA4 GADD45A GADD45A CDH1 CDH1 POLK POLK KRAS KRAS GADD45G GADD45G
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
BAXApoptosis regulator BAX. (192 aa)
ERASGTPase ERas. (225 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (442 aa)
CCDC6Coiled-coil domain-containing protein 6. (476 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
TFGProtein TFG isoform X1. (400 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
CTNNB1Catenin beta-1. (781 aa)
TPRNucleoprotein TPR isoform X1. (2438 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
HRASGTPase HRas isoform X1. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
TPM3Tropomyosin alpha-3 chain isoform X2; Belongs to the tropomyosin family. (284 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PAX8Paired box protein Pax-8 isoform X1. (458 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
NCOA4Nuclear receptor coactivator 4 isoform X1. (625 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
POLKDNA polymerase kappa. (878 aa)
KRASGTPase KRas isoform X3. (227 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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