STRINGSTRING
WNT9A WNT9A BMP2 BMP2 WNT2B WNT2B WNT7A WNT7A FZD4 FZD4 PTCH2 PTCH2 WNT10A WNT10A WNT6 WNT6 SMO SMO WNT3 WNT3 FZD2 FZD2 WNT9B WNT9B AXIN2 AXIN2 DVL1 DVL1 AXIN1 AXIN1 GLI2 GLI2 FZD10 FZD10 WNT2 WNT2 FZD7 FZD7 WNT16 WNT16 WNT11 WNT11 TCF7L2 TCF7L2 CTNNB1 CTNNB1 PTCH1 PTCH1 KIF27 KIF27 WNT8A WNT8A DDB2 DDB2 TP53 TP53 WNT5A WNT5A FZD9 FZD9 TCF7 TCF7 TCF7L1 TCF7L1 FZD6 FZD6 APC APC LEF1 LEF1 GADD45B GADD45B APC2 APC2 FZD5 FZD5 SHH SHH WNT7B WNT7B GLI1 GLI1 WNT10B WNT10B HHIP HHIP WNT1 WNT1 WNT8B WNT8B GADD45A GADD45A BMP4 BMP4 SUFU SUFU GLI3 GLI3 WNT5B WNT5B POLK POLK GADD45G GADD45G DVL2 DVL2 WNT3A WNT3A LOC112413704 LOC112413704 FZD1 FZD1 CDKN1A CDKN1A BAK1 BAK1 WNT4 WNT4 KIF7 KIF7 FZD3 FZD3 DVL3 DVL3 GSK3B GSK3B BAX BAX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
BMP2Bone morphogenetic protein 2 isoform X1. (395 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
PTCH2Protein patched homolog 2 isoform X1. (1234 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
AXIN2Axin-2. (720 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
AXIN1Axin-1 isoform X1. (866 aa)
GLI2LOW QUALITY PROTEIN: zinc finger protein GLI2. (1541 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
CTNNB1Catenin beta-1. (781 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
KIF27Kinesin-like protein KIF27 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1405 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
APCAdenomatous polyposis coli protein isoform X1. (2863 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
APC2Adenomatous polyposis coli protein 2. (1995 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
SHHSonic hedgehog protein. (328 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1106 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
HHIPHedgehog-interacting protein. (700 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
GLI3Transcriptional activator GLI3. (1587 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
POLKDNA polymerase kappa. (878 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC112413704LOW QUALITY PROTEIN: frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (420 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
KIF7Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1319 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
BAXApoptosis regulator BAX. (192 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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