STRINGSTRING
SPIB SPIB PIM2 PIM2 AKT2 AKT2 ERAS ERAS SOS2 SOS2 LOC112392089 LOC112392089 KRAS KRAS CEBPE CEBPE LOC112397463 LOC112397463 CSF2 CSF2 CSF1R CSF1R LOC112395092 LOC112395092 CHUK CHUK NFKB1 NFKB1 MAP2K1 MAP2K1 LOC112392034 LOC112392034 CEBPA CEBPA EIF4EBP1 EIF4EBP1 IKBKB IKBKB NRAS NRAS CSDE1 CSDE1 MAPK1 MAPK1 PML PML GRB2 GRB2 RUNX1T1 RUNX1T1 RUNX1 RUNX1 LOC112408488 LOC112408488 AKT1 AKT1 MPO MPO RPS6KB1 RPS6KB1 LOC112407246 LOC112407246 RAF1 RAF1 TCF7L2 TCF7L2 PIK3CA PIK3CA FLT3 FLT3 CCNA1 CCNA1 DUSP6 DUSP6 AKT3 AKT3 SOS1 SOS1 CD14 CD14 PER2 PER2 PIK3R1 PIK3R1 ZBTB16 ZBTB16 PIK3CB PIK3CB ARAF ARAF PIK3CD PIK3CD MTOR MTOR BAD BAD RELA RELA CCND1 CCND1 HRAS HRAS RPS6KB2 RPS6KB2 SPI1 SPI1 KIT KIT IKBKG IKBKG MAP2K2 MAP2K2 JUP JUP LOC112400438 LOC112400438 TCF7 TCF7 ITGAM ITGAM STAT3 STAT3 LOC112399174 LOC112399174 CCNA2 CCNA2 TCF7L1 TCF7L1 MAPK3 MAPK3 STAT5A STAT5A LOC112398305 LOC112398305 RARA RARA BRAF BRAF MYC MYC LEF1 LEF1 PPARD PPARD PIM1 PIM1 PIK3R2 PIK3R2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPIBTranscription factor Spi-B isoform X1. (262 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERASGTPase ERas. (225 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
KRASGTPase KRas isoform X3. (227 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
LOC112397463Interleukin-3-like. (149 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (134 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
LOC112395092Protein CBFA2T1. (481 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1. (744 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
LOC112392034Signal transducer and activator of transcription 5A-like. (105 aa)
CEBPACCAAT/enhancer-binding protein. (315 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E-binding protein 1. (118 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (821 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
PMLProtein PML isoform X1. (965 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RUNX1T1Protein CBFA2T1. (144 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
MPOMyeloperoxidase. (718 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
LOC112407246LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 14B-like. (156 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1136 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (421 aa)
DUSP6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (381 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
CD14Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (372 aa)
PER2Period circadian protein homolog 2 isoform X1. (1294 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
BADBcl2-associated agonist of cell death. (168 aa)
RELATranscription factor p65. (562 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
SPI1Transcription factor PU.1 isoform X1. (271 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
IKBKGNF-kappa-B essential modulator isoform X1. (498 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
JUPJunction plakoglobin. (744 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
ITGAMIntegrin alpha-M isoform X1; Belongs to the integrin alpha chain family. (1153 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
LOC112399174Signal transducer and activator of transcription. (618 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (432 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
STAT5ASignal transducer and activator of transcription. (726 aa)
LOC112398305Bcl-2-related protein A1. (175 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
PPARDPeroxisome proliferator-activated receptor delta. (441 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (349 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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