STRINGSTRING
FZD3 FZD3 BAX BAX ERAS ERAS AKT2 AKT2 GSK3B GSK3B DLL3 DLL3 FGF21 FGF21 DVL3 DVL3 E2F2 E2F2 PIK3R2 PIK3R2 NOTCH3 NOTCH3 CDK6 CDK6 WNT4 WNT4 BAK1 BAK1 CDKN1A CDKN1A FLT4 FLT4 FZD1 FZD1 LOC112413704 LOC112413704 WNT3A WNT3A WNT9A WNT9A EGFR EGFR FGFR1 FGFR1 WNT2B WNT2B NRAS NRAS CSDE1 CSDE1 NOTCH2 NOTCH2 NCOA1 NCOA1 WNT7A WNT7A FZD4 FZD4 MAPK1 MAPK1 WNT10A WNT10A WNT6 WNT6 NOTCH1 NOTCH1 GRB2 GRB2 EYS EYS WNT3 WNT3 PGR PGR HES5 HES5 FZD2 FZD2 WNT9B WNT9B AXIN2 AXIN2 DVL1 DVL1 JAG2 JAG2 FGF20 FGF20 HEY2 HEY2 AXIN1 AXIN1 NCOA7 NCOA7 FZD10 FZD10 WNT2 WNT2 LOC112408488 LOC112408488 AKT1 AKT1 FZD7 FZD7 WNT16 WNT16 WNT11 WNT11 RPS6KB1 RPS6KB1 RAF1 RAF1 RB1 RB1 JUN JUN TCF7L2 TCF7L2 PIK3CA PIK3CA LOC112406592 LOC112406592 BRCA2 BRCA2 TNFSF11 TNFSF11 CTNNB1 CTNNB1 AKT3 AKT3 FGF9 FGF9 FGF5 FGF5 SOS1 SOS1 WNT8A WNT8A FGF18 FGF18 PIK3R1 PIK3R1 HES1 HES1 LOC112403409 LOC112403409 PIK3CB PIK3CB ESR2 ESR2 ARAF ARAF PIK3CD PIK3CD FGF19 FGF19 FGF4 FGF4 MTOR MTOR SHC4 SHC4 CEP152 CEP152 CCND1 CCND1 LRP5 LRP5 DDB2 DDB2 HRAS HRAS RPS6KB2 RPS6KB2 GALK2 GALK2 TP53 TP53 FGF7 FGF7 CCDC170 CCDC170 ESR1 ESR1 SHC1 SHC1 FGF17 FGF17 KIT KIT WNT5A WNT5A FZD9 FZD9 MAP2K2 MAP2K2 NCOA3 NCOA3 LOC112400438 LOC112400438 DLL1 DLL1 FGF2 FGF2 TCF7 TCF7 PTEN PTEN TCF7L1 TCF7L1 MAPK3 MAPK3 FZD6 FZD6 E2F1 E2F1 ERBB2 ERBB2 APC APC BRAF BRAF EGF EGF BRCA1 BRCA1 MYC MYC LEF1 LEF1 SHC2 SHC2 FGF10 FGF10 E2F3 E2F3 GADD45B GADD45B FGF22 FGF22 APC2 APC2 FZD5 FZD5 HEYL HEYL GPSM3 GPSM3 FOS FOS NOTCH4 NOTCH4 CSNK1A1 CSNK1A1 WNT7B WNT7B CDK4 CDK4 WNT10B WNT10B SP1 SP1 WNT1 WNT1 WNT8B WNT8B GADD45A GADD45A JAG1 JAG1 MAP2K1 MAP2K1 NFKB2 NFKB2 FGF8 FGF8 LOC112392931 LOC112392931 LOC112392971 LOC112392971 LRP6 LRP6 LOC112392060 LOC112392060 FGF6 FGF6 FGF23 FGF23 SOS2 SOS2 WNT5B WNT5B LOC112392089 LOC112392089 POLK POLK DLL4 DLL4 IGF1R IGF1R KRAS KRAS HEY1 HEY1 IGF1 IGF1 GADD45G GADD45G SHC3 SHC3 DVL2 DVL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
BAXApoptosis regulator BAX. (192 aa)
ERASGTPase ERas. (225 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
DLL3Delta-like protein 3. (587 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
NOTCH3Neurogenic locus notch homolog protein 3. (2320 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
FLT4Vascular endothelial growth factor receptor 3 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1368 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
LOC112413704LOW QUALITY PROTEIN: frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (420 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform X1. (2485 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
NOTCH1LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1. (2633 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
EYSLOW QUALITY PROTEIN: protein eyes shut homolog. (3129 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
PGRProgesterone receptor. (888 aa)
HES5Transcription factor HES-5. (94 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
AXIN2Axin-2. (720 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1064 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (337 aa)
AXIN1Axin-1 isoform X1. (866 aa)
NCOA7Nuclear receptor coactivator 7 isoform X1. (943 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RB1Retinoblastoma-associated protein. (816 aa)
JUNLOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC112406592Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3435 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (323 aa)
CTNNB1Catenin beta-1. (781 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HES1Transcription factor HES-1. (280 aa)
LOC112403409LOW QUALITY PROTEIN: restin homolog. (543 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
ESR2Estrogen receptor beta isoform X1. (527 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SHC4SHC-transforming protein 4 isoform X1. (630 aa)
CEP152Centrosomal protein of 152 kDa. (1724 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
HRASGTPase HRas isoform X1. (189 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
GALK2N-acetylgalactosamine kinase isoform X1. (498 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
CCDC170LOW QUALITY PROTEIN: coiled-coil domain-containing protein 170. (730 aa)
ESR1Estrogen receptor. (604 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
NCOA3Nuclear receptor coactivator. (1400 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (759 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
E2F1Transcription factor E2F1. (360 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
APCAdenomatous polyposis coli protein isoform X1. (2863 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1870 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
SHC2SHC-transforming protein 2. (426 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
E2F3Transcription factor E2F3. (349 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
APC2Adenomatous polyposis coli protein 2. (1995 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (357 aa)
GPSM3G-protein-signaling modulator 3. (162 aa)
FOSProto-oncogene c-Fos. (380 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1993 aa)
CSNK1A1Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (365 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
CDK4Cyclin-dependent kinase 4 isoform X1; Belongs to the protein kinase superfamily. (303 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SP1Transcription factor Sp1. (780 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1177 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit isoform X1. (900 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
LOC112392931GSK-3-binding protein FRAT2-like. (114 aa)
LOC112392971LOW QUALITY PROTEIN: proto-oncogene FRAT1-like. (250 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (212 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
POLKDNA polymerase kappa. (878 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
IGF1RTyrosine-protein kinase receptor. (1368 aa)
KRASGTPase KRas isoform X3. (227 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1. (304 aa)
IGF1Insulin-like growth factor I isoform X1. (208 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SHC3SHC-transforming protein 3. (470 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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