STRINGSTRING
FGF6 FGF6 LRP6 LRP6 LOC112392971 LOC112392971 LOC112392931 LOC112392931 FGF8 FGF8 CCNE1 CCNE1 CDH1 CDH1 SMAD3 SMAD3 MAP2K1 MAP2K1 TGFBR1 TGFBR1 GADD45A GADD45A WNT8B WNT8B GAB1 GAB1 WNT1 WNT1 WNT10B WNT10B CDK2 CDK2 WNT7B WNT7B CSNK1A1 CSNK1A1 RARB RARB TGFB3 TGFB3 SHH SHH TGFB2 TGFB2 FZD5 FZD5 ABCB1 ABCB1 APC2 APC2 FGF22 FGF22 GADD45B GADD45B E2F3 E2F3 FGF10 FGF10 SHC2 SHC2 WNT4 WNT4 LEF1 LEF1 RXRG RXRG MYC MYC EGF EGF BRAF BRAF APC APC ERBB2 ERBB2 E2F1 E2F1 TGFBR2 TGFBR2 FZD6 FZD6 MAPK3 MAPK3 TCF7L1 TCF7L1 TCF7 TCF7 FGF2 FGF2 LOC112400438 LOC112400438 JUP JUP MAP2K2 MAP2K2 LOC112400428 LOC112400428 FZD9 FZD9 WNT5A WNT5A FGF17 FGF17 SHC1 SHC1 FGF7 FGF7 TP53 TP53 GALK2 GALK2 RPS6KB2 RPS6KB2 HRAS HRAS DDB2 DDB2 LRP5 LRP5 CCND1 CCND1 CEP152 CEP152 SHC4 SHC4 MTOR MTOR FGF4 FGF4 FGF19 FGF19 PIK3CD PIK3CD ARAF ARAF PIK3CB PIK3CB CTNNA1 CTNNA1 HGF HGF PIK3R1 PIK3R1 FGF18 FGF18 WNT8A WNT8A SOS1 SOS1 FGF5 FGF5 FGF9 FGF9 AKT3 AKT3 CTNNB1 CTNNB1 BCL2 BCL2 PIK3CA PIK3CA FGFR2 FGFR2 TCF7L2 TCF7L2 MLH1 MLH1 LOC112406920 LOC112406920 RB1 RB1 RAF1 RAF1 SMAD2 SMAD2 CCNE2 CCNE2 SMAD4 SMAD4 RPS6KB1 RPS6KB1 WNT11 WNT11 WNT16 WNT16 MET MET FZD7 FZD7 AKT1 AKT1 LOC112408488 LOC112408488 WNT2 WNT2 FZD10 FZD10 AXIN1 AXIN1 FGF20 FGF20 DVL1 DVL1 AXIN2 AXIN2 WNT9B WNT9B FZD2 FZD2 WNT3 WNT3 GRB2 GRB2 RXRA RXRA WNT6 WNT6 WNT10A WNT10A MAPK1 MAPK1 LOC112411691 LOC112411691 FZD4 FZD4 WNT7A WNT7A CSDE1 CSDE1 NRAS NRAS WNT2B WNT2B EGFR EGFR PIK3R2 PIK3R2 BAK1 BAK1 CDKN1A CDKN1A CTNNA2 CTNNA2 FZD1 FZD1 RXRB RXRB LOC112413704 LOC112413704 CDH17 CDH17 REG4 REG4 WNT3A WNT3A CTNNA3 CTNNA3 WNT9A WNT9A BAX BAX ERAS ERAS SOS2 SOS2 WNT5B WNT5B LOC112392089 LOC112392089 TERT TERT POLK POLK CDKN1B CDKN1B KRAS KRAS GADD45G GADD45G SHC3 SHC3 DVL2 DVL2 FGF23 FGF23 FZD3 FZD3 AKT2 AKT2 GSK3B GSK3B FGF21 FGF21 TGFB1 TGFB1 DVL3 DVL3 CDKN2B CDKN2B E2F2 E2F2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa)
LOC112392971LOW QUALITY PROTEIN: proto-oncogene FRAT1-like. (250 aa)
LOC112392931GSK-3-binding protein FRAT2-like. (114 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (885 aa)
SMAD3Mothers against decapentaplegic homolog. (376 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (438 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha. (165 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (325 aa)
GAB1GRB2-associated-binding protein 1 isoform X3. (724 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
CSNK1A1Casein kinase I isoform X1; Belongs to the protein kinase superfamily. (365 aa)
RARBRetinoic acid receptor beta. (311 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
SHHSonic hedgehog protein. (328 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (555 aa)
ABCB1Multidrug resistance protein 1. (1284 aa)
APC2Adenomatous polyposis coli protein 2. (1995 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (265 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta. (160 aa)
E2F3Transcription factor E2F3. (349 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SHC2SHC-transforming protein 2. (426 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (414 aa)
RXRGRetinoic acid receptor RXR-gamma isoform X1. (463 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1238 aa)
BRAFSerine/threonine-protein kinase B-raf isoform X1. (581 aa)
APCAdenomatous polyposis coli protein isoform X1. (2863 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
E2F1Transcription factor E2F1. (360 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
TCF7L1Transcription factor 7-like 1 isoform X1. (463 aa)
TCF7Transcription factor 7 isoform X1. (303 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (304 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
JUPJunction plakoglobin. (744 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
LOC112400428LOW QUALITY PROTEIN: catenin alpha-1-like. (875 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (564 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (204 aa)
SHC1SHC-transforming protein 1 isoform X1. (609 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
GALK2N-acetylgalactosamine kinase isoform X1. (498 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (486 aa)
HRASGTPase HRas isoform X1. (189 aa)
DDB2DNA damage-binding protein 2 isoform X1. (457 aa)
LRP5Low-density lipoprotein receptor-related protein 5 isoform X1. (1461 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
CEP152Centrosomal protein of 152 kDa. (1724 aa)
SHC4SHC-transforming protein 4 isoform X1. (630 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (363 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X1. (625 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
CTNNA1Catenin alpha-1. (906 aa)
HGFHepatocyte growth factor isoform X1; Belongs to the peptidase S1 family. (734 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (300 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SOS1Son of sevenless homolog 1 isoform X1. (1350 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (270 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
CTNNB1Catenin beta-1. (781 aa)
BCL2Apoptosis regulator Bcl-2 isoform X1. (233 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
TCF7L2Transcription factor 7-like 2 isoform X1. (510 aa)
MLH1LOW QUALITY PROTEIN: DNA mismatch repair protein Mlh1. (753 aa)
LOC112406920Lithostathine-like. (174 aa)
RB1Retinoblastoma-associated protein. (816 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
SMAD4Mothers against decapentaplegic homolog. (599 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
LOC112408488Serine/threonine-protein kinase B-raf-like. (250 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
AXIN1Axin-1 isoform X1. (866 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
AXIN2Axin-2. (720 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (602 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
GRB2Growth factor receptor-bound protein 2. (217 aa)
RXRARetinoic acid receptor RXR-alpha. (439 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
LOC112411691Retinoic acid receptor beta-like. (329 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NRASGTPase NRas. (189 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
BAK1Bcl-2 homologous antagonist/killer isoform X1. (239 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (164 aa)
CTNNA2Catenin alpha-2 isoform X1. (953 aa)
FZD1Frizzled-1; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
RXRBRetinoic acid receptor RXR-beta isoform X1. (442 aa)
LOC112413704LOW QUALITY PROTEIN: frizzled-8-like; Belongs to the G-protein coupled receptor Fz/Smo family. (420 aa)
CDH17Cadherin-17. (832 aa)
REG4LOW QUALITY PROTEIN: regenerating islet-derived protein 4. (203 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CTNNA3LOW QUALITY PROTEIN: catenin alpha-3. (895 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (428 aa)
BAXApoptosis regulator BAX. (192 aa)
ERASGTPase ERas. (225 aa)
SOS2Son of sevenless homolog 2 isoform X1. (1272 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1136 aa)
POLKDNA polymerase kappa. (878 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
KRASGTPase KRas isoform X3. (227 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
SHC3SHC-transforming protein 3. (470 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (212 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (131 aa)
E2F2Transcription factor E2F2 isoform X1. (437 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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