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SLC7A5 SLC7A5 SLC2A2 SLC2A2 PGAM1 PGAM1 PDGFRA PDGFRA MAP2K2 MAP2K2 PDHB PDHB PDHA2 PDHA2 LOC112394703 LOC112394703 PFKM PFKM GLS2 GLS2 IDH1 IDH1 PDHA1 PDHA1 PARP8 PARP8 MYC MYC HK3 HK3 ERBB2 ERBB2 MAPK3 MAPK3 PTEN PTEN SLC2A1 SLC2A1 SIRT6 SIRT6 LOC112400438 LOC112400438 G6PD G6PD LOC112392089 LOC112392089 PGAM2 PGAM2 KIT KIT GCK GCK LOC112401637 LOC112401637 NTRK1 NTRK1 HIF1A HIF1A TP53 TP53 HRAS HRAS SIRT3 SIRT3 MTOR MTOR PIK3CD PIK3CD PIK3CB PIK3CB RET RET HK2 HK2 PIK3R1 PIK3R1 LOC112405116 LOC112405116 AKT3 AKT3 PFKP PFKP FLT3 FLT3 LOC112406592 LOC112406592 PIK3CA PIK3CA FGFR2 FGFR2 RAF1 RAF1 MET MET AKT1 AKT1 PFKL PFKL SLC16A3 SLC16A3 PKM PKM PARP6 PARP6 LDHAL6B LDHAL6B MAPK1 MAPK1 LOC112412867 LOC112412867 CSDE1 CSDE1 NRAS NRAS LOC112412913 LOC112412913 FGFR1 FGFR1 EGFR EGFR HKDC1 HKDC1 HK1 HK1 IDH2 IDH2 PIK3R2 PIK3R2 SLC1A5 SLC1A5 AKT2 AKT2 ERAS ERAS LOC112392078 LOC112392078 KRAS KRAS PDK1 PDK1 PDGFRB PDGFRB FGFR3 FGFR3 TNIK TNIK LOC112391556 LOC112391556 LDHB LDHB TIGAR TIGAR NTRK3 NTRK3 LOC112392060 LOC112392060 GLS GLS MAP2K1 MAP2K1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC7A5Large neutral amino acids transporter small subunit 1. (478 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
PDHA2annotation not available (387 aa)
LOC112394703Protein SCO2 homolog, mitochondrial. (266 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
GLS2Glutaminase liver isoform, mitochondrial. (602 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
PARP8Poly [ADP-ribose] polymerase. (929 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
HK3Hexokinase-3 isoform X1. (989 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (354 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase. (614 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
GCKPhosphotransferase. (537 aa)
LOC112401637L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (374 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
HRASGTPase HRas isoform X1. (189 aa)
SIRT3NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1. (152 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
HK2Hexokinase-2. (917 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LOC112405116Protein SCO1 homolog, mitochondrial. (190 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1136 aa)
LOC112406592Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (732 aa)
SLC16A3Monocarboxylate transporter 4 isoform X1. (574 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
LDHAL6BLOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6B; Belongs to the LDH/MDH superfamily. (335 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
LOC112412867LOW QUALITY PROTEIN: L-lactate dehydrogenase C chain-like; Belongs to the LDH/MDH superfamily. (224 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
NRASGTPase NRas. (189 aa)
LOC112412913L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
SLC1A5Amino acid transporter. (592 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ERASGTPase ERas. (225 aa)
LOC112392078NAD-dependent protein deacetylase sirtuin-3, mitochondrial-like. (196 aa)
KRASGTPase KRas isoform X3. (227 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
TNIKTRAF2 and NCK-interacting protein kinase isoform X1. (1331 aa)
LOC112391556Tyrosine-protein kinase receptor. (342 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (269 aa)
NTRK3NT-3 growth factor receptor. (514 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
GLSLOW QUALITY PROTEIN: glutaminase kidney isoform, mitochondrial. (674 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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