STRINGSTRING
G6PD G6PD ERAS ERAS AKT2 AKT2 SLC1A5 SLC1A5 PIK3R2 PIK3R2 IDH2 IDH2 HK1 HK1 HKDC1 HKDC1 EGFR EGFR FGFR1 FGFR1 LOC112412913 LOC112412913 NRAS NRAS CSDE1 CSDE1 LOC112412867 LOC112412867 MAPK1 MAPK1 LDHAL6B LDHAL6B PARP6 PARP6 PKM PKM SLC16A3 SLC16A3 PFKL PFKL AKT1 AKT1 MET MET RAF1 RAF1 FGFR2 FGFR2 PIK3CA PIK3CA LOC112406592 LOC112406592 FLT3 FLT3 PFKP PFKP AKT3 AKT3 LOC112405116 LOC112405116 PIK3R1 PIK3R1 HK2 HK2 RET RET PIK3CB PIK3CB PIK3CD PIK3CD MTOR MTOR SIRT3 SIRT3 HRAS HRAS TP53 TP53 HIF1A HIF1A NTRK1 NTRK1 LOC112401637 LOC112401637 GCK GCK KIT KIT PGAM2 PGAM2 PDHB PDHB MAP2K2 MAP2K2 PDGFRA PDGFRA LOC112400438 LOC112400438 SIRT6 SIRT6 SLC2A1 SLC2A1 PTEN PTEN MAPK3 MAPK3 ERBB2 ERBB2 HK3 HK3 MYC MYC PARP8 PARP8 PDHA1 PDHA1 IDH1 IDH1 GLS2 GLS2 PFKM PFKM LOC112394703 LOC112394703 PDHA2 PDHA2 PGAM1 PGAM1 SLC2A2 SLC2A2 SLC7A5 SLC7A5 MAP2K1 MAP2K1 GLS GLS LOC112392060 LOC112392060 NTRK3 NTRK3 TIGAR TIGAR LDHB LDHB LOC112391556 LOC112391556 TNIK TNIK FGFR3 FGFR3 PDGFRB PDGFRB LOC112392089 LOC112392089 LOC112392078 LOC112392078 KRAS KRAS PDK1 PDK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G6PDGlucose-6-phosphate 1-dehydrogenase. (614 aa)
ERASGTPase ERas. (225 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
SLC1A5Amino acid transporter. (592 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (723 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
HK1Hexokinase-1 isoform X2. (935 aa)
HKDC1Putative hexokinase HKDC1 isoform X1. (917 aa)
EGFRReceptor protein-tyrosine kinase. (1156 aa)
FGFR1Fibroblast growth factor receptor. (722 aa)
LOC112412913L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (798 aa)
LOC112412867LOW QUALITY PROTEIN: L-lactate dehydrogenase C chain-like; Belongs to the LDH/MDH superfamily. (224 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
LDHAL6BLOW QUALITY PROTEIN: L-lactate dehydrogenase A-like 6B; Belongs to the LDH/MDH superfamily. (335 aa)
PARP6Poly [ADP-ribose] polymerase. (631 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
SLC16A3Monocarboxylate transporter 4 isoform X1. (574 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (732 aa)
AKT1RAC-alpha serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (339 aa)
METHepatocyte growth factor receptor isoform X1. (1382 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
FGFR2Fibroblast growth factor receptor. (841 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC112406592Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2-like isoform X1. (598 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1136 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (791 aa)
AKT3Non-specific serine/threonine protein kinase. (531 aa)
LOC112405116Protein SCO1 homolog, mitochondrial. (190 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
HK2Hexokinase-2. (917 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1078 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa)
SIRT3NAD-dependent protein deacetylase sirtuin-3, mitochondrial isoform X1. (152 aa)
HRASGTPase HRas isoform X1. (189 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
HIF1AHypoxia-inducible factor 1-alpha. (823 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
LOC112401637L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (374 aa)
GCKPhosphotransferase. (537 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (253 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2. (303 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC112400438Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (354 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
MAPK3Mitogen-activated protein kinase 3. (265 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HK3Hexokinase-3 isoform X1. (989 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
PARP8Poly [ADP-ribose] polymerase. (929 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
GLS2Glutaminase liver isoform, mitochondrial. (602 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (851 aa)
LOC112394703Protein SCO2 homolog, mitochondrial. (266 aa)
PDHA2annotation not available (387 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (524 aa)
SLC7A5Large neutral amino acids transporter small subunit 1. (478 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
GLSLOW QUALITY PROTEIN: glutaminase kidney isoform, mitochondrial. (674 aa)
LOC112392060Fibroblast growth factor receptor 1-like. (98 aa)
NTRK3NT-3 growth factor receptor. (514 aa)
TIGARFructose-2,6-bisphosphatase TIGAR isoform X1. (269 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
LOC112391556Tyrosine-protein kinase receptor. (342 aa)
TNIKTRAF2 and NCK-interacting protein kinase isoform X1. (1331 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
LOC112392089RAC-alpha serine/threonine-protein kinase. (138 aa)
LOC112392078NAD-dependent protein deacetylase sirtuin-3, mitochondrial-like. (196 aa)
KRASGTPase KRas isoform X3. (227 aa)
PDK1Protein-serine/threonine kinase. (378 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
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