61 items (Neophocaena asiaeorientalis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL22	Interleukin-22. (189 aa)
	TGFB3	Transforming growth factor beta-3. (456 aa)
	IL6	Interleukin-6. (208 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	IL18RAP	Interleukin-18 receptor accessory protein isoform X1. (584 aa)
	IL18R1	Interleukin-18 receptor 1 isoform X1. (555 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (265 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	IL21R	Interleukin-21 receptor. (537 aa)
	TBX21	T-box transcription factor TBX21. (501 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (832 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
	FOXP3	LOW QUALITY PROTEIN: forkhead box protein P3. (452 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	IL13	Interleukin-13. (145 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2 isoform X1. (1021 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	IL12RB1	Interleukin-12 receptor subunit beta-1 isoform X1. (762 aa)
	LOC112414040	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family. (250 aa)
	LOC112413938	HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family. (260 aa)
	LOC112414069	HLA class II histocompatibility antigen, DM beta chain isoform X1. (263 aa)
	IL17A	interleukin-17A isoform X1. (155 aa)
	IL17F	interleukin-17F. (165 aa)
	TLR4	Toll-like receptor 4 isoform X1; Belongs to the Toll-like receptor family. (841 aa)
	RORC	Nuclear receptor ROR-gamma isoform X1. (544 aa)
	IFNGR1	Interferon gamma receptor 1 isoform X1. (468 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (364 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	LOC112408477	Uncharacterized protein LOC112408477. (247 aa)
	TLR2	Toll-like receptor 2; Belongs to the Toll-like receptor family. (785 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	JUN	LOW QUALITY PROTEIN: transcription factor AP-1; Belongs to the bZIP family. (284 aa)
	LOC112406848	DLA class II histocompatibility antigen, DR-1 beta chain-like. (266 aa)
	LOC112406849	boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1. (276 aa)
	NFATC1	Nuclear factor of activated T-cells, cytoplasmic 1. (700 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL10	Interleukin-10. (178 aa)
	TLR5	Toll-like receptor 5 isoform X1; Belongs to the Toll-like receptor family. (865 aa)
	RELA	Transcription factor p65. (562 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	DMA	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family. (261 aa)
	DRA	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family. (253 aa)
	Neas-DQA	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family. (255 aa)
	Neas-DOB	HLA class II histocompatibility antigen, DO beta chain. (273 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	IL23R	Interleukin-23 receptor. (630 aa)
	SMAD3	Mothers against decapentaplegic homolog. (376 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	MAF	LOW QUALITY PROTEIN: transcription factor Maf; Belongs to the bZIP family. (323 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2 isoform X1. (859 aa)
	RORA	Nuclear receptor ROR-alpha. (386 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	IL23A	Interleukin-23 subunit alpha. (189 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DMA	DRA	A0A0U2GPM3	A0A0U2GPH7	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	0.994
DMA	LOC112406848	A0A0U2GPM3	A0A341CA33	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.980
DMA	LOC112406849	A0A0U2GPM3	A0A341CA17	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1.	0.971
DMA	LOC112413938	A0A0U2GPM3	A0A341D7D8	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family.	0.543
DMA	LOC112414040	A0A0U2GPM3	A0A341D7V7	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.992
DMA	LOC112414069	A0A0U2GPM3	A0A341D5D9	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM beta chain isoform X1.	0.999
DMA	Neas-DOB	A0A0U2GPM3	A0A0R9CVE8	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DO beta chain.	0.986
DMA	Neas-DQA	A0A0U2GPM3	A0A0R9D118	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family.	0.951
DRA	DMA	A0A0U2GPH7	A0A0U2GPM3	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM alpha chain isoform X1; Belongs to the MHC class II family.	0.994
DRA	LOC112406848	A0A0U2GPH7	A0A341CA33	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	DLA class II histocompatibility antigen, DR-1 beta chain-like.	0.990
DRA	LOC112406849	A0A0U2GPH7	A0A341CA17	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1.	0.989
DRA	LOC112408477	A0A0U2GPH7	A0A341CGW1	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	Uncharacterized protein LOC112408477.	0.940
DRA	LOC112413938	A0A0U2GPH7	A0A341D7D8	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM alpha chain isoform X2; Belongs to the MHC class II family.	0.994
DRA	LOC112414040	A0A0U2GPH7	A0A341D7V7	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DO alpha chain-like; Belongs to the MHC class II family.	0.928
DRA	LOC112414069	A0A0U2GPH7	A0A341D5D9	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM beta chain isoform X1.	0.998
DRA	Neas-DOB	A0A0U2GPH7	A0A0R9CVE8	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DO beta chain.	0.990
DRA	Neas-DQA	A0A0U2GPH7	A0A0R9D118	HLA class II histocompatibility antigen, DR alpha chain; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DQ alpha 2 chain; Belongs to the MHC class II family.	0.982
FOXP3	GATA3	A0A341BFI0	A0A341ABP1	LOW QUALITY PROTEIN: forkhead box protein P3.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.804
FOXP3	IFNG	A0A341BFI0	A0A341APD9	LOW QUALITY PROTEIN: forkhead box protein P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.914
FOXP3	IL10	A0A341BFI0	A0A341BVQ6	LOW QUALITY PROTEIN: forkhead box protein P3.	Interleukin-10.	0.756