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| | thmA | Amphipathic pore-forming peptide precursor. (76 aa) |
| | strH | Beta-N-acetyl-hexosaminidase precursor. (1312 aa) |
| | spr0072 | Conserved hypothetical protein. (179 aa) |
| | spr0074 | Hypothetical protein. (136 aa) |
| | spr0091 | Conserved hypothetical protein; Putative sugar transferase related protein. (385 aa) |
| | capD | CapD protein, required for the biosynthesis of type 1 capsular polysaccharide. (616 aa) |
| | pspA | Surface protein pspA precursor. (619 aa) |
| | epsG | Glycosyltransferase involved exopolysaccharide (EPS) synthesis. (404 aa) |
| | spr0136 | Glycosyl transferase, family 2. (317 aa) |
| | spr0157 | Conserved hypothetical protein. (420 aa) |
| | uppS | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (258 aa) |
| | hysA | Hyaluronate lyase precursor (hyaluronidase/hyase). (1078 aa) |
| | spr0312 | Degenerate transposase. (53 aa) |
| | cps2A | The type 2 capsule locus of Streptococcus pneumoniae. (320 aa) |
| | cps2H | The type 2 capsule locus of Streptococcus pneumoniae. (344 aa) |
| | cps2I | The type 2 capsule locus of Streptococcus pneumoniae. (385 aa) |
| | cps2J | The type 2 capsule locus of Streptococcus pneumoniae. (469 aa) |
| | cps2K | The type 2 capsule locus of Streptococcus pneumoniae. (412 aa) |
| | cps2P | The type 2 capsule locus of Streptococcus pneumoniae. (201 aa) |
| | cps2L | The type 2 capsule locus of Streptococcus pneumoniae; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (289 aa) |
| | cps2M | The type 2 capsule locus of Streptococcus pneumoniae. (197 aa) |
| | cpsN | dTDP-glucose-4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (349 aa) |
| | cpsO | dTDP-L-rhamnose synthase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (283 aa) |
| | spr0324 | Transposase, uncharacterized, truncation. (148 aa) |
| | spr0325 | Hypothetical protein. (149 aa) |
| | spr0326 | Hypothetical protein. (52 aa) |
| | spr0333 | Conserved hypothetical protein; Belongs to the methyltransferase superfamily. (390 aa) |
| | mapZ | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. (464 aa) |
| | csrR | Response regulator. (229 aa) |
| | cbpF | Choline-binding protein F. (338 aa) |
| | mvk | Mevalonate kinase. (292 aa) |
| | mvd1 | Diphosphomevalonate decarboxylase. (344 aa) |
| | mvaK2 | Phosphomevalonate kinase. (335 aa) |
| | fni | Isopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (336 aa) |
| | spr0342 | Conserved hypothetical protein. (232 aa) |
| | hk03 | Histidine kinase. (331 aa) |
| | rr03 | Response regulator. (210 aa) |
| | spr0345 | DNA alkylation repair enzyme, truncation. (48 aa) |
| | spr0346 | DNA alkylation repair enzyme, truncation. (84 aa) |
| | spr0347 | DNA alkylation repair enzyme, truncation. (90 aa) |
| | spr0348 | Hypothetical protein. (64 aa) |
| | spr0349 | Choline binding protein G, truncation. (218 aa) |
| | cbpG | Choline binding protein G. (42 aa) |
| | pcpC | Choline-binding protein. (294 aa) |
| | spr0361 | Conserved hypothetical protein. (37 aa) |
| | prtA | Cell wall-associated serine proteinase precursor PrtA. (2144 aa) |
| | spr0574 | Conserved hypothetical protein. (291 aa) |
| | zmpB | Zinc metalloprotease; Similar to IgA1 protease. (1876 aa) |
| | spr0583 | Hypothetical protein; Similar to 1,4-beta-N-acetylmuramidase. (329 aa) |
| | ciaR | Response regulator, transcriptional regulatory protein; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. (246 aa) |
| | ciaH | Sensor protein CiaH histide kinase; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR. (444 aa) |
| | spr0719 | Transposase. (59 aa) |
| | spr0810 | Hypothetical protein. (100 aa) |
| | lytB | Endo-beta-N-acetylglucosaminidase; Plays an important role in cell wall degradation and cell separation. (721 aa) |
| | flpA | Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. (560 aa) |
| | lmb | Lipoprotein; Belongs to the bacterial solute-binding protein 9 family. (311 aa) |
| | phtD | Pneumococcal histidine triad protein D precursor. (853 aa) |
| | phtE | Pneumococcal histidine triad protein E precursor. (1039 aa) |
| | spr0909 | Hypothetical protein. (46 aa) |
| | spr0910 | Pneumococcal histidine triad protein E precursor, truncation. (182 aa) |
| | mesH | MesH protein. (143 aa) |
| | spr0955 | Hypothetical protein in TN5252. (119 aa) |
| | spr0956 | Hypothetical protein. (109 aa) |
| | spr0958 | Tn5252, relaxase, truncation. (185 aa) |
| | spr0959 | Hypothetical protein. (198 aa) |
| | ABC-NBD-17 | ABC transporter ATP-binding protein - unknown substrate. (633 aa) |
| | iga | Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. (1963 aa) |
| | phpA | Histidine Motif-Containing protein. (855 aa) |
| | phtA | Pneumococcal histidine triad protein A precursor. (828 aa) |
| | ispA | Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (291 aa) |
| | licC | Homologous to LicC, which regulates expression of LPS epitopes in H. influenzae. (229 aa) |
| | licB | Homologous to LicB, which regulates expression of LPS epitopes in H. influenzae. (296 aa) |
| | pck | Choline kinase. (289 aa) |
| | tarJ | Conserved hypothetical protein; Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate. (346 aa) |
| | tarI | Conserved hypothetical protein; Catalyzes the transfer of the cytidylyl group of CTP to D- ribitol 5-phosphate. (235 aa) |
| | spr1150 | Conserved hypothetical protein; Probable oligosaccharide repeat unit transporter. (495 aa) |
| | licD1 | Required for phosphorylcholine incorporation in teichoic and lipoteichoic acids. (267 aa) |
| | licD2 | licD Protein; Required for phosphorylcholine incorporation in teichoic and lipoteichoic acids. (269 aa) |
| | spr1221 | Hypothetical protein. (344 aa) |
| | spr1222 | Hypothetical protein. (477 aa) |
| | cps23FU | Galactosyl transferase paralog. (328 aa) |
| | spr1224 | Conserved hypothetical protein; Similar to capsular polysaccharide biosynthsis protein. (385 aa) |
| | licD1-2 | LicD1 paralog. (281 aa) |
| | spr1274 | Choline binding protein. (129 aa) |
| | spr1294 | Hypothetical protein. (153 aa) |
| | spr1295 | Transposase, uncharacterized, truncation. (70 aa) |
| | spr1296 | Hypothetical protein. (122 aa) |
| | Transposase_E | Degenerate transposase. (116 aa) |
| | spr1299 | Degenerate transposase (orf1). (79 aa) |
| | lytC | 1,4-beta-N-acetylmuramidase. (501 aa) |
| | gtrB | Glycosil transferase. (363 aa) |
| | psaB | ABC transporter ATP-binding protein - manganese transport. (240 aa) |
| | psaC | ABC transporter membrane-spanning permease - manganese transport. (282 aa) |
| | psaA | ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. (309 aa) |
| | nanB | Sialidase B precursor (neuraminidase B). (697 aa) |
| | nanA | Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. (1035 aa) |
| | mvaA | 3-hydroxy-3-methylglutaryl-coenzyme a reductase; Belongs to the HMG-CoA reductase family. (424 aa) |
| | mvaS | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase. (398 aa) |
| | spr1654 | Conserved hypothetical protein; Putative role in biosynthesis of amino sugar; Belongs to the DegT/DnrJ/EryC1 family. (417 aa) |
| | spr1655 | Conserved hypothetical protein; Putative glycosyltransferase. (243 aa) |
| | spr1708 | Hypothetical protein. (397 aa) |
| | ply | Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). (471 aa) |
| | lytA | Autolysin (N-acetylmuramoyl-L-alanine amidase). (318 aa) |
| | pcpA | Choline-binding protein. (690 aa) |
| | adcA | ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family. (501 aa) |
| | adcB | ABC transporter membrane-spanning permease - Zinc (Zn2+) transport. (278 aa) |
| | adcC | ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity). (234 aa) |
| | adcR | Transcriptional repressor for Zn(2+)-responsive expression. (166 aa) |
| | dltD | D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain. (427 aa) |
| | dltC | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa) |
| | dltB | D-alanine transfer from Dcp to undecaprenol-phosphate; Could be involved in the transport of activated D-alanine through the membrane. (414 aa) |
| | dltA | D-alanine-D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP [...] (488 aa) |
| | pspC | Choline binding protein A. (701 aa) |
| | cbpD | Choline binding protein D. (448 aa) |
| | Transposase_G | Transposase, uncharacterized, truncation. (89 aa) |
| | spr2018 | Degenerate transposase. (95 aa) |
| | spr2036 | Conserved hypothetical protein. (850 aa) |
| | sphtra | Serine protease. (397 aa) |
