(37 nodes) Mixed, incl. Cell wall/choline-binding repeat, and PhtA domain superfamily network (Streptococcus pneumoniae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	strH	Beta-N-acetyl-hexosaminidase precursor. (1312 aa)
	pspA	Surface protein pspA precursor. (619 aa)
	spr0157	Conserved hypothetical protein. (420 aa)
	hysA	Hyaluronate lyase precursor (hyaluronidase/hyase). (1078 aa)
	cbpF	Choline-binding protein F. (338 aa)
	spr0349	Choline binding protein G, truncation. (218 aa)
	cbpG	Choline binding protein G. (42 aa)
	pcpC	Choline-binding protein. (294 aa)
	prtA	Cell wall-associated serine proteinase precursor PrtA. (2144 aa)
	zmpB	Zinc metalloprotease; Similar to IgA1 protease. (1876 aa)
	spr0583	Hypothetical protein; Similar to 1,4-beta-N-acetylmuramidase. (329 aa)
	lytB	Endo-beta-N-acetylglucosaminidase; Plays an important role in cell wall degradation and cell separation. (721 aa)
	flpA	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. (560 aa)
	lmb	Lipoprotein; Belongs to the bacterial solute-binding protein 9 family. (311 aa)
	phtD	Pneumococcal histidine triad protein D precursor. (853 aa)
	phtE	Pneumococcal histidine triad protein E precursor. (1039 aa)
	spr0909	Hypothetical protein. (46 aa)
	spr0910	Pneumococcal histidine triad protein E precursor, truncation. (182 aa)
	iga	Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region. (1963 aa)
	phpA	Histidine Motif-Containing protein. (855 aa)
	phtA	Pneumococcal histidine triad protein A precursor. (828 aa)
	spr1274	Choline binding protein. (129 aa)
	lytC	1,4-beta-N-acetylmuramidase. (501 aa)
	psaB	ABC transporter ATP-binding protein - manganese transport. (240 aa)
	psaC	ABC transporter membrane-spanning permease - manganese transport. (282 aa)
	psaA	ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. (309 aa)
	nanB	Sialidase B precursor (neuraminidase B). (697 aa)
	nanA	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. (1035 aa)
	ply	Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity). (471 aa)
	lytA	Autolysin (N-acetylmuramoyl-L-alanine amidase). (318 aa)
	pcpA	Choline-binding protein. (690 aa)
	adcA	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family. (501 aa)
	adcB	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport. (278 aa)
	adcC	ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity). (234 aa)
	adcR	Transcriptional repressor for Zn(2+)-responsive expression. (166 aa)
	pspC	Choline binding protein A. (701 aa)
	cbpD	Choline binding protein D. (448 aa)

Your Current Organism:

Streptococcus pneumoniae

NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
adcA	adcB	spr1975	spr1976	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	0.999
adcA	adcC	spr1975	spr1977	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity).	0.999
adcA	adcR	spr1975	spr1978	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Transcriptional repressor for Zn(2+)-responsive expression.	0.999
adcA	lmb	spr1975	spr0906	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Lipoprotein; Belongs to the bacterial solute-binding protein 9 family.	0.999
adcA	phpA	spr1975	spr1060	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Histidine Motif-Containing protein.	0.967
adcA	phtA	spr1975	spr1061	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Pneumococcal histidine triad protein A precursor.	0.736
adcA	phtD	spr1975	spr0907	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Pneumococcal histidine triad protein D precursor.	0.999
adcA	phtE	spr1975	spr0908	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Pneumococcal histidine triad protein E precursor.	0.656
adcA	psaA	spr1975	spr1494	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily.	0.420
adcA	psaB	spr1975	spr1492	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	ABC transporter ATP-binding protein - manganese transport.	0.978
adcA	psaC	spr1975	spr1493	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	ABC transporter membrane-spanning permease - manganese transport.	0.959
adcA	spr0909	spr1975	spr0909	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Hypothetical protein.	0.831
adcA	spr0910	spr1975	spr0910	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	Pneumococcal histidine triad protein E precursor, truncation.	0.678
adcB	adcA	spr1976	spr1975	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.	0.999
adcB	adcC	spr1976	spr1977	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity).	0.999
adcB	adcR	spr1976	spr1978	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	Transcriptional repressor for Zn(2+)-responsive expression.	0.999
adcB	lmb	spr1976	spr0906	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	Lipoprotein; Belongs to the bacterial solute-binding protein 9 family.	0.998
adcB	phpA	spr1976	spr1060	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	Histidine Motif-Containing protein.	0.751
adcB	phtA	spr1976	spr1061	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	Pneumococcal histidine triad protein A precursor.	0.594
adcB	phtD	spr1976	spr0907	ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.	Pneumococcal histidine triad protein D precursor.	0.999

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