STRINGSTRING
comA comA comB comB rr08 rr08 hk08 hk08 spr0105 spr0105 spr0106 spr0106 spr0107 spr0107 spr0108 spr0108 spr0109 spr0109 tag tag spr0167 spr0167 blpT blpT blpS blpS rr13 rr13 hk13 hk13 ip ip spr0466 spr0466 spr0467 spr0467 spr0468 spr0468 spr0469 spr0469 spr0470 spr0470 spr0471 spr0471 blpY blpY blpZ blpZ pncP pncP vex1 vex1 vex2 vex2 vex3 vex3 pep27 pep27 vncR vncR vncS vncS spr0606 spr0606 spr0609 spr0609 spr0610 spr0610 spr0611 spr0611 spr0693 spr0693 ABC-NBD-11 ABC-NBD-11 spr0695 spr0695 ABC-NBD-14 ABC-NBD-14 ABC-MSD-3 ABC-MSD-3 spr0852 spr0852 spr0853 spr0853 spr0854 spr0854 spr0855 spr0855 spr0858 spr0858 spr0859 spr0859 spr0860 spr0860 pmrA pmrA spr1201 spr1201 ABC-NDB ABC-NDB ABC-NP-2 ABC-NP-2 ptrB ptrB spr1205 spr1205 trzA trzA ABC-N/P ABC-N/P ABC-N/P-2 ABC-N/P-2 spr1275 spr1275 spr1278 spr1278 spr1279 spr1279 spr1280 spr1280 ABC-NBD-20 ABC-NBD-20 spr1371 spr1371 spr1372 spr1372 spr1374 spr1374 snf snf patB patB spr1378 spr1378 spr1379 spr1379 spr1380 spr1380 spr1381 spr1381 whiA whiA spr1423 spr1423 aldR aldR spr1428 spr1428 dpr dpr hk01 hk01 rr01 rr01 spr1496 spr1496 ABC-NBD-23 ABC-NBD-23 spr1622 spr1622 ABC-N/P-5 ABC-N/P-5 ABC-N/P-6 ABC-N/P-6 spr1658 spr1658 spr1659 spr1659 ydfG ydfG spr1726 spr1726 spr1728 spr1728 spr1729 spr1729 spr1730 spr1730 spr1731 spr1731 spr1732 spr1732 spr1733 spr1733 spr1734 spr1734 spr1735 spr1735 spr1736 spr1736 spr1737 spr1737 spr1764 spr1764 spr1765 spr1765 spr1766 spr1766 cylM cylM spr1768 spr1768 spr1769 spr1769 clyB clyB nisP nisP spr1772 spr1772 ABC-NBD-27 ABC-NBD-27 spr1774 spr1774 rr11 rr11 hk11 hk11 spr1816 spr1816 ABC-NBD-29 ABC-NBD-29 spr1818 spr1818 spr1826 spr1826 spr1880 spr1880 spr1883 spr1883 guaA-2 guaA-2 ABC-NP-3 ABC-NP-3 spr1886 spr1886 ABC-NP-4 ABC-NP-4 spr1996 spr1996 hk06 hk06 rr06 rr06
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
comATransport ATP-binding protein ComA; Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP) (By similarity); Belongs to the ABC transporter superfamily. HlyB family. (717 aa)
comBTransport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (449 aa)
rr08Response regulator. (232 aa)
hk08Histidine kinase. (350 aa)
spr0105Transporter, truncation. (77 aa)
spr0106Transporter, truncation; Similar to competence factor transporting ATP-binding/permease protein ComA. (644 aa)
spr0107Hypothetical protein. (155 aa)
spr0108Conserved hypothetical protein; Similar to ComB protein. (450 aa)
spr0109Hypothetical protein. (126 aa)
tag3-Methyladenine DNA glycosylase I, constitutive. (187 aa)
spr0167Conserved hypothetical protein. (225 aa)
blpTHypothetical protein. (109 aa)
blpSRegulatory protein. (112 aa)
rr13Response regulator. (245 aa)
hk13Histidine kinase. (446 aa)
ipBacteriocin-like peptide, double glycine cleavage type. (51 aa)
spr0466Conserved hypothetical protein, truncation; blpB. (335 aa)
spr0467Conserved hypothetical protein, truncation; blpB. (111 aa)
spr0468Conserved hypothetical protein, truncation; blpA. (541 aa)
spr0469Conserved hypothetical protein, truncation; blpA. (197 aa)
spr0470Hypothetical protein. (77 aa)
spr0471Hypothetical protein. (59 aa)
blpYBlpY protein. (229 aa)
blpZHypothetical protein. (77 aa)
pncPABC transporter ATP binding protein - unknown substrate. (203 aa)
vex1ABC transporter membrane-spanning permease - Pep export. (425 aa)
vex2ABC transporter ATP-binding protein - Pep export. (215 aa)
vex3ABC transporter membrane-spanning permease - Pep export. (459 aa)
pep27A secreted peptide which is the signal sensed by VncR/S. (27 aa)
vncRVncR, response regulator. (218 aa)
vncSVncS, histidine kinase. (442 aa)
spr0606Hypothetical protein. (76 aa)
spr0609ABC transporter ATP-binding protein - unknown substrate, truncation. (41 aa)
spr0610ABC transporter ATP-binding protein - unknown substrate, truncation. (217 aa)
spr0611Putative membrane spanning protein. (237 aa)
spr0693Conserved hypothetical protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (399 aa)
ABC-NBD-11ABC transporter ATP-binding protein - unknown substrate. (233 aa)
spr0695Conserved hypothetical protein. (419 aa)
ABC-NBD-14ABC transporter ATP-binding protein - unknown substrate. (271 aa)
ABC-MSD-3ABC transporter membrane-spanning permease - unknown substrate. (662 aa)
spr0852Alanine dehydrogenase, truncation. (91 aa)
spr0853Alanine dehydrogenase, truncation. (87 aa)
spr0854Alanine dehydrogenase, truncation. (141 aa)
spr0855Conserved hypothetical protein; Probable acetyl transferase. (189 aa)
spr0858Hypothetical protein. (62 aa)
spr0859Hypothetical protein. (165 aa)
spr0860Hypothetical protein. (393 aa)
pmrAMajor facilitator superfamily multi-drug resistance efflux pump; Efflux pump for various substrates; Belongs to the major facilitator superfamily. TCR/Tet family. (399 aa)
spr1201Hypothetical protein. (439 aa)
ABC-NDBABC transporter ATP-binding protein - unknown substrate. (252 aa)
ABC-NP-2ABC transporter ATP-binding/membrane spanning protein - multidrug resistance. (535 aa)
ptrBProtease II (oligopeptidase B). (646 aa)
spr1205Conserved hypothetical protein. (878 aa)
trzAN-ethylammeline chlorohydrolase. (488 aa)
ABC-N/PABC transporter ATP-binding/membrane-spanning protein - unknown substrate. (596 aa)
ABC-N/P-2ABC transporter ATP-binding/membrane-spanning protein - unknown substrate. (574 aa)
spr1275Conserved hypothetical protein; Putative alanine acetyl transferase. (183 aa)
spr1278Hypothetical protein. (162 aa)
spr1279Conserved hypothetical protein; Putative transcription regulator. (79 aa)
spr1280Hypothetical protein. (242 aa)
ABC-NBD-20ABC transporter ATP-binding protein - multidrug efflux. (240 aa)
spr1371Conserved hypothetical protein; Putative acetyltransferase. (164 aa)
spr1372Hypothetical protein; N-terminal acetyltransferase related protein. (154 aa)
spr1374Hypothetical protein. (205 aa)
snfSWF/SNF family ATP-dependent RNA helicase. (1032 aa)
patBAminotransferase. (388 aa)
spr1378ABC transporter, truncation. (50 aa)
spr1379ABC transporter, truncation. (150 aa)
spr1380ABC transporter, truncation. (207 aa)
spr1381ABC transporter, truncation. (100 aa)
whiAConserved hypothetical protein; Involved in cell division and chromosome segregation. (303 aa)
spr1423Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (325 aa)
aldRTranscription regulator. (126 aa)
spr1428Hypothetical protein. (56 aa)
dprDNA binding protein starved cells-like peroxide resistance protein; Belongs to the Dps family. (178 aa)
hk01Histidine kinase. (324 aa)
rr01Response regulator. (225 aa)
spr1496Hypothetical protein. (924 aa)
ABC-NBD-23ABC transporter ATP-binding protein - unknown substrate. (236 aa)
spr1622Conserved hypothetical protein; Putative regulator protein. (512 aa)
ABC-N/P-5ABC transporter ATP-binding/membrane spanning protein - unknown substrate. (583 aa)
ABC-N/P-6ABC transporter ATP-binding/membrane spanning protein - unknown substrate. (594 aa)
spr1658Conserved hypothetical protein. (176 aa)
spr1659Hypothetical protein. (89 aa)
ydfGOxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (253 aa)
spr1726Conserved hypothetical protein; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (208 aa)
spr1728Hypothetical protein. (99 aa)
spr1729Conserved hypothetical protein. (71 aa)
spr1730Hypothetical protein. (224 aa)
spr1731Hypothetical protein. (149 aa)
spr1732Conserved hypothetical protein; Similar to bacteriocin transport permease. (167 aa)
spr1733Hypothetical protein. (120 aa)
spr1734ABC transporter ATP-binding protein - unknown substrate, truncation. (343 aa)
spr1735ABC transporter ATP-binding protein - unknown substrate, truncation. (56 aa)
spr1736ABC transporter ATP-binding protein - unknown substrate, truncation. (215 aa)
spr1737Conserved hypothetical protein; Putative transcriptional regulator. (114 aa)
spr1764Hypothetical protein. (56 aa)
spr1765Hypothetical protein. (74 aa)
spr1766Hypothetical protein. (62 aa)
cylMCylM protein, cytolytic toxin system. (996 aa)
spr1768Conserved hypothetical protein; Related to Trp repressor binding protein. (234 aa)
spr1769Hypothetical protein. (309 aa)
clyBABC transporter ATP-binding/membrane-spanning - hemolysin secretion protein. (702 aa)
nisPSubtilisin-like serine protease. (579 aa)
spr1772Hypothetical protein, truncation. (255 aa)
ABC-NBD-27ABC transporter ATP-binding protein - unknown substrate. (210 aa)
spr1774Hypothetical protein. (53 aa)
rr11Response regulator. (199 aa)
hk11Histidine kinase. (365 aa)
spr1816Conserved hypothetical protein. (255 aa)
ABC-NBD-29ABC transporter ATP binding protein - unknown substrate. (294 aa)
spr1818Hypothetical protein. (68 aa)
spr1826Conserved hypothetical protein. (326 aa)
spr1880Conserved hypothetical protein; Low similarity to cytidine/deoxycytidylate deaminases. (144 aa)
spr1883Hypothetical protein. (59 aa)
guaA-2Glutamine amidotransferase. (245 aa)
ABC-NP-3ABC transporter ATP-binding/membrane spanning protein - unknown substrate. (603 aa)
spr1886Degenerate transposase. (104 aa)
ABC-NP-4ABC transporter ATP-binding/membrane spanning protein - unknown substrate. (564 aa)
spr1996Conserved hypothetical protein. (175 aa)
hk06Histidine kinase. (443 aa)
rr06Response regulator. (217 aa)
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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