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prsA prsA pflE pflE pflF pflF talC talC adhP adhP gnd gnd pfl pfl pgk pgk fba fba glcK glcK lctO lctO spxB spxB rpiA rpiA deoB deoB deoC deoC pfkA pfkA pykF pykF prs prs pta pta gapN gapN eno eno lplA lplA acoL acoL acoC acoC acoB acoB acoA acoA ldh ldh zwf zwf pgm pgm spr1358 spr1358 tpi tpi merA merA gpmA gpmA PTS-EII-15 PTS-EII-15 acyP acyP pflC pflC rpe rpe gapA gapA adhE adhE tktA tktA ackA ackA adh adh gpi gpi tktC tktC tktN tktN adh2 adh2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prsAPhosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (339 aa)
pflEPyruvate formate-lyase 3. (258 aa)
pflFFormate acetyltransferase 3. (815 aa)
talCTransaldolase C. (222 aa)
adhPAlcohol dehydrogenase, propanol-preferring. (339 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (474 aa)
pflPyruvate formate-lyase. (774 aa)
pgkPhosphoglycerate kinase. (398 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (293 aa)
glcKGlucose kinase. (325 aa)
lctOLactate oxidase. (378 aa)
spxBPyruvate oxidase; Belongs to the TPP enzyme family. (591 aa)
rpiARibose-5-phosphate epimerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (246 aa)
deoBPhosphodeoxyribomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose. (424 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
pfkA6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (335 aa)
pykFPyruvate kinase I; fructose-stimulated. (501 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa)
ptaPhosphate acetyltransferase. (324 aa)
gapNNADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (434 aa)
lplALipoate protein ligase A. (329 aa)
acoLDihydrolipoamide dehydrogenase. (567 aa)
acoCDihydrolipoamide S-acetyltransferase. (375 aa)
acoBTPP-dependent acetoin dehydrogenase beta chain. (330 aa)
acoATPP-dependent acetoin dehydrogenase alpha chain. (322 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (495 aa)
pgmPhosphoglucomutase. (572 aa)
spr1358Conserved hypothetical protein. (337 aa)
tpiTriose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (259 aa)
merAOxidoreductase (Mercury (II) reductase). (438 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (230 aa)
PTS-EII-15Phosphotransferase system sugar-specific EII component. (510 aa)
acyPAcylphosphate phosphohydrolase. (92 aa)
pflCPyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (264 aa)
rpePentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
gapAGlyceraldehyde 3-phosphate dehydrogenase (phosphorylating); Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (359 aa)
adhEAlcohol-acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (890 aa)
tktATransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa)
ackAAcetate kinase (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
adhPutative alcohol dehydrogenase. (352 aa)
gpiGlucose-6-phosphate isomerase. (449 aa)
tktCPutative transketolase c-terminal section. (310 aa)
tktNPutative transketolase n-terminal section. (285 aa)
adh2Probable alcohol dehydrogenase. (383 aa)
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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