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| | glnP | ABC transporter membrane-spanning permease - glutamine transport. (219 aa) |
| | dnaA | DNA biosynthesis, initiation, binding protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (453 aa) |
| | ftsH | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. (652 aa) |
| | spr0034 | Conserved hypothetical protein. (340 aa) |
| | comA | Transport ATP-binding protein ComA; Required for induction of competence. Seems to transport the competence-stimulating peptide (CSP) (By similarity); Belongs to the ABC transporter superfamily. HlyB family. (717 aa) |
| | comB | Transport protein ComB; Required for induction of competence; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (449 aa) |
| | PTS-EIIC | Phosphotransferase system sugar-specific EIIC component. (301 aa) |
| | PTS-EIID | Phosphotransferase system sugar-specific EIID component. (276 aa) |
| | agaS | Tagatose-6-phosphate ketose/aldose isomerase. (388 aa) |
| | hk08 | Histidine kinase. (350 aa) |
| | ABC-MSP | ABC transporter membrane-spanning permease - sugar transport. (319 aa) |
| | ABC-MSP-2 | ABC transporter membrane spanning permease - sugar transport. (307 aa) |
| | spr0090 | Conserved hypothetical protein. (388 aa) |
| | ABC-NBD | ABC transporter ATP-binding protein - amino acid transport. (213 aa) |
| | spr0144 | Conserved hypothetical protein. (409 aa) |
| | spr0145 | Hypothetical protein. (198 aa) |
| | ABC-NBD-2 | ABC transporter ATP-binding protein - unknown substrate; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (353 aa) |
| | ABC-MSD | ABC transporter membrane-spanning permease - unknown substrate. (230 aa) |
| | cls | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (510 aa) |
| | secY | Multispanning membrane protein, translocator of proteins; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move indepen [...] (436 aa) |
| | ABC-MSP-4 | ABC transporter membrane-spanning permease - iron transport. (344 aa) |
| | ABC-MSP-5 | ABC transporter membrane-spanning permease - iron transport. (208 aa) |
| | ABC-NBD-3 | ABC transporter ATP-binding protein - iron transport; Belongs to the ABC transporter superfamily. (363 aa) |
| | PTS-EIIC-2 | Phosphotransferase system sugar-specific EIIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (440 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (267 aa) |
| | eep | Determinant for enhanced expression of pheromone; Belongs to the peptidase M50B family. (419 aa) |
| | spr0255 | Conserved hypothetical protein. (76 aa) |
| | manN | Phosphotransferase system, mannose-specific EIID. (303 aa) |
| | manM | Phosphotransferase system, mannose-specific EIIC. (267 aa) |
| | manL | Phosphotransferase system, mannose-specific EIIAB. (332 aa) |
| | spr0264 | Conserved hypothetical protein. (490 aa) |
| | PTS-EII-4 | Phosphotransferase system sugar-specific EII component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (448 aa) |
| | PTS-EII-7 | Phosphotransferase system sugar-specific EII component. (259 aa) |
| | PTS-EII-8 | Phosphotransferase system sugar-specific EII component. (272 aa) |
| | spr0296 | Conserved hypothetical protein. (97 aa) |
| | ftsL | Cell division protein; Essential cell division protein; Belongs to the FtsL family. (105 aa) |
| | pbpX | Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. (750 aa) |
| | mraY | Undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (326 aa) |
| | cps2J | The type 2 capsule locus of Streptococcus pneumoniae. (469 aa) |
| | aliA | ABC transporter substrate-binding protein - oligopeptide transport. (660 aa) |
| | mapZ | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. (464 aa) |
| | hk03 | Histidine kinase. (331 aa) |
| | mtlA | Mannitol PTS EII; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (589 aa) |
| | mtlF | Mannitol-specific enzyme IIA component. (145 aa) |
| | spi | Signal peptidase I; Belongs to the peptidase S26 family. (204 aa) |
| | dagA | D-alanine glycine permease. (440 aa) |
| | shetA | Exfoliative toxin A. (303 aa) |
| | glnH | ABC transporter substrate binding protein - glutamine transport. (311 aa) |
| | bacA | A lipid kinase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (281 aa) |
| | PTS-EII-9 | Phosphotransferase system sugar-specific EII component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (441 aa) |
| | PTS-EII-11 | Phosphotransferase system sugar-specific EII component. (559 aa) |
| | trkH-2 | Trk transporter membrane-spanning protein - K+ transport. (479 aa) |
| | trkA-2 | Trk transporter NAD+ binding protein - K+ transport. (449 aa) |
| | spr0429 | Conserved hypothetical protein. (182 aa) |
| | ABC-NBD-4 | ABC transporter ATP-binding protein - cobalt transport; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). (560 aa) |
| | ABC-MSD-2 | ABC transporter membrane-spanning permease - unknown substrate. (276 aa) |
| | spr0433 | Conserved hypothetical protein; Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins; Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family. (192 aa) |
| | spr0439 | Conserved hypothetical protein; Probable integral membrane protein. (543 aa) |
| | spr0442 | Hypothetical protein. (175 aa) |
| | PTS-EII-12 | Phosphotransferase system sugar-specific EII component. (612 aa) |
| | vex1 | ABC transporter membrane-spanning permease - Pep export. (425 aa) |
| | vex2 | ABC transporter ATP-binding protein - Pep export. (215 aa) |
| | vex3 | ABC transporter membrane-spanning permease - Pep export. (459 aa) |
| | glnP-2 | ABC transporter membrane-spanning permease - glutamine transport. (225 aa) |
| | brnQ | Branched-chain amino acid transport system carrier protein; Component of the transport system for branched-chain amino acids. (446 aa) |
| | PTS-EII-14 | Phosphotransferase system sugar-specific EII component. (491 aa) |
| | nha2 | Na+/H+ antiporter. (684 aa) |
| | hk09 | Histidine kinase. (563 aa) |
| | ABC-NBD-7 | ABC transporter ATP-binding protein - sodium transport. (213 aa) |
| | murG | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (352 aa) |
| | divIB | Cell division protein DivIB; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex. (396 aa) |
| | glnP-3 | ABC transporter membrane-spanning permease - glutamine transport. (225 aa) |
| | glnP-4 | ABC transporter membrane-spanning permease - glutamine transport. (226 aa) |
| | lctO | Lactate oxidase. (378 aa) |
| | ABC-NBD-9 | ABC transporter ATP-binding protein - cobalt or other cation transport. (461 aa) |
| | ctpA | P-type ATPase - probable copper transporter. (750 aa) |
| | livH | ABC transporter membrane-spanning permease - branched chain amino acid transport; Belongs to the binding-protein-dependent transport system permease family. (292 aa) |
| | livM | ABC transporter membrane-spanning permease - branched chain amino acid transport; Belongs to the binding-protein-dependent transport system permease family. (318 aa) |
| | livG | ABC transporter ATP-binding protein - branched chain amino acid transport. (254 aa) |
| | ftsE | ABC transporter ATP-binding protein & cell division protein; Part of the ABC transporter FtsEX involved in cellular division. (230 aa) |
| | ftsX | Cell division protein FtsX; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (329 aa) |
| | ptsG | PTS glucose-specific enzyme IIABC component. (726 aa) |
| | bioY | Biotin synthase. (178 aa) |
| | spr0695 | Conserved hypothetical protein. (419 aa) |
| | ciaH | Sensor protein CiaH histide kinase; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR. (444 aa) |
| | rodA | Rod shape determining protein; Belongs to the SEDS family. (416 aa) |
| | ezrA | Cell division regulator, negative regulator of FtsZ ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (584 aa) |
| | glnP-5 | ABC transporter membrane-spanning permease - glutamine transport. (229 aa) |
| | spr0747 | Conserved hypothetical protein; Similar to basic membrane protein A from Lactococcus lactis subsp. lactis. (374 aa) |
| | ABC-MSP-7 | ABC transporter membrane-spanning permease - ribose/galactose transport; Belongs to the binding-protein-dependent transport system permease family. (361 aa) |
| | ABC-MSP-8 | ABC transporter membrane-spanning permease - ribose/galactose transport; Belongs to the binding-protein-dependent transport system permease family. (318 aa) |
| | plsY | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (213 aa) |
| | parC | Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (826 aa) |
| | fruA | Fructose specific-phosphotransferase system IIBC component. (650 aa) |
| | ftsK | Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity). Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination; Belongs to the FtsK/SpoIIIE/SftA family. (767 aa) |
| | spr0805 | Conserved hypothetical protein. (301 aa) |
| | spr0810 | Hypothetical protein. (100 aa) |
| | ABC-MSD-3 | ABC transporter membrane-spanning permease - unknown substrate. (662 aa) |
| | lspA | Signal peptidase type II; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. (153 aa) |
| | celB | Competence induced; comE-like protein B; Putative DNA uptake by homology. (746 aa) |
| | dgkA | Diacylglycerol kinase. (131 aa) |
| | era | GTPase/GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity). Complements an E.coli era disruption mutant. Binds 16S rRNA as well as poly(U) RNA, binding to the latter is inhibited by liposomes; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family. (299 aa) |
| | pmrA | Major facilitator superfamily multi-drug resistance efflux pump; Efflux pump for various substrates; Belongs to the major facilitator superfamily. TCR/Tet family. (399 aa) |
| | secG | Protein-export membrane protein secG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (77 aa) |
| | ppmA | Proteinase maturation protein; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (313 aa) |
| | mscL | Large conductance mechano-sensitive ion channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell. (125 aa) |
| | mesH | MesH protein. (143 aa) |
| | ABC-MSP-9 | ABC transporter membrane-spanning permease - iron transport; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (339 aa) |
| | ABC-MSP-10 | ABC transporter membrane-spanning permease - iron transport; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (335 aa) |
| | mefE | ABC transporter membrane-spanning permease - macrolide efflux. (403 aa) |
| | ftsW | Cell division protein FtsW; Belongs to the SEDS family. (409 aa) |
| | ABC-MSP-11 | ABC transporter membrane-spanning permease - unknown substrate; Belongs to the binding-protein-dependent transport system permease family. (288 aa) |
| | ABC-NBD-16 | ABC transporter ATP-binding protein - unknown substrate. (252 aa) |
| | cpoA | Glycosyltransferase; Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn- glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)- 1,2-diacyl-sn-glycerol). It ca [...] (374 aa) |
| | spr0982 | Conserved Hypothetical protein; Glucosyltransferase involved in the biosynthesis of the non- bilayer-prone membrane lipid alpha-monoglucosyldiacylglycerol. This is a major component for maintaining a certain anionic lipid surface charge density, for balancing the bilayer to non-bilayer phase equilibria and for keeping a constant lipid bilayer spontaneous curvature (curvature packing stress). Catalyzes the transfer of a glucosyl residue from UDP-Glc to diacylglycerol (DAG) acceptor to form the corresponding alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D- glucopyranosyl)-sn-glycerol). It ca [...] (441 aa) |
| | spr0983 | Hypothetical protein. (58 aa) |
| | spr1018 | Conserved hypothetical protein. (282 aa) |
| | ABC-MSP-12 | ABC transporter membrane-spanning permease - macrolide efflux. (392 aa) |
| | spr1045 | Conserved hypothetical protein; Putative channel transporter. (521 aa) |
| | norM | Conserved hypothetical protein; Multidrug efflux pump; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (453 aa) |
| | lacE | PTS system, lactose-specific IIBC component. (563 aa) |
| | lepA | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (607 aa) |
| | nirC | Formate-nitrate transporter. (265 aa) |
| | glnP-6 | ABC transporter membrane spanning permease - glutamine transport. (721 aa) |
| | ftsY | Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (425 aa) |
| | spr1140 | Conserved hypothetical protein. (119 aa) |
| | spr1150 | Conserved hypothetical protein; Probable oligosaccharide repeat unit transporter. (495 aa) |
| | htpX | Heat shock protein; Belongs to the peptidase M48B family. (302 aa) |
| | pyrP | Uracil permease. (439 aa) |
| | crcB | CrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (109 aa) |
| | crcB-2 | CrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. (124 aa) |
| | appC | ABC transporter membrane-spanning permease - oligopeptide transport. (283 aa) |
| | appB | ABC transporter membrane-spanning permease - oligopeptide transport. (331 aa) |
| | appA | ABC transporter substrate-binding protein - oligopeptide transport. (542 aa) |
| | spr1201 | Hypothetical protein. (439 aa) |
| | ABC-NDB | ABC transporter ATP-binding protein - unknown substrate. (252 aa) |
| | ABC-N/P-2 | ABC transporter ATP-binding/membrane-spanning protein - unknown substrate. (574 aa) |
| | msrA-2 | Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (By similarity). Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (312 aa) |
| | potC | ABC transporter membrane-spanning permease - spermidine/putrescine transport. (257 aa) |
| | potB | ABC transporter membrane-spanning permease - spermidine/putrescine transport. (275 aa) |
| | potA | ABC transporter ATP-binding protein - spermidine/putrescine transport; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (385 aa) |
| | pstB | ABC transporter ATP-binding protein - phosphate transport; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (252 aa) |
| | pstB-2 | ABC transporter ATP-binding protein - phosphate transport; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (267 aa) |
| | pstA | ABC transporter membrane-spanning permease - phosphate transport. (294 aa) |
| | pstC | ABC transporter membrane-spanning permease - phosphate transport; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (305 aa) |
| | pstS | ABC transporter substrate-binding protein - phosphate transport; Part of the ABC transporter complex PstSACB involved in phosphate import. (292 aa) |
| | lgt | Prolipoprotein diacylglycerol transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. (266 aa) |
| | ABC-N/P-3 | ABC transporter ATP-binding/membrane-spanning protein - unknown substrate. (586 aa) |
| | ABC-N/P-4 | ABC transporter ATP-binding/membrane-spanning protein - unknown substrate. (581 aa) |
| | spr1292 | Conserved hypothetical protein. (231 aa) |
| | ABC-NBD-21 | ABC transporter ATP-binding protein - unknown substrate. (454 aa) |
| | ABC-MSP-13 | ABC transporter membrane-spanning permease - aspartate/glutamate transport. (266 aa) |
| | pgdA | Peptidoglycan GlcNAc deacetylase; Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan, a modification that confers host lysozyme resistance and contributes to pneumococcal virulence. (463 aa) |
| | glpF | Glycerol uptake facilitator protein paralog; Belongs to the MIP/aquaporin (TC 1.A.8) family. (289 aa) |
| | glnP-7 | ABC transporter membrane-spanning permease - glutamine transport. (232 aa) |
| | atpC | Proton-translocating ATPase, F1 sector, epsilon-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane; Belongs to the ATPase epsilon chain family. (139 aa) |
| | atpD | Proton-translocating ATPase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa) |
| | atpG | Proton-translocating ATPase, F1 sector, gamma-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpA | Proton-translocating ATPase, F1 sector, alpha-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (501 aa) |
| | atpH | Proton-translocating ATPase, F1 sector, delta-subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa) |
| | atpF | Proton-translocating ATPase, F0 sector, subunit b; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (164 aa) |
| | atpB | Proton-translocating ATPase, F0 sector, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (238 aa) |
| | atpE | Proton-translocating ATPase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (66 aa) |
| | mltG | Hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (551 aa) |
| | aliB | ABC transporter substrate-binding protein - oligopeptide transport; Part of the binding-protein-dependent transport system for oligopeptides; probably an oligopeptide binding protein; Belongs to the bacterial solute-binding protein 5 family. (652 aa) |
| | spr1383 | Polysaccharide transporter. (540 aa) |
| | dacA-2 | Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (292 aa) |
| | msmK | ABC transporter ATP-binding protein - multiple sugar transport; Belongs to the ABC transporter superfamily. (376 aa) |
| | cshA-2 | Conserved hypothetical protein; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (524 aa) |
| | oxlT | Major facilitator:Oxalate:Formate Antiporter. (408 aa) |
| | spr1453 | Major facilitator superfamily transporter - efflux. (383 aa) |
| | gtrB | Glycosil transferase. (363 aa) |
| | ctpE | P-type ATPase - metal cation transport. (778 aa) |
| | pepO | Endopeptidase O. (630 aa) |
| | psaB | ABC transporter ATP-binding protein - manganese transport. (240 aa) |
| | psaC | ABC transporter membrane-spanning permease - manganese transport. (282 aa) |
| | psaA | ABC transporter substrate-binding protein - manganese transport; Part of an ATP-driven transport system; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. (309 aa) |
| | spr1496 | Hypothetical protein. (924 aa) |
| | ftsA | Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (457 aa) |
| | pbp2b | Penicillin-binding protein 2B. (685 aa) |
| | ABC-MSP-14 | ABC transporter membrane-spanning permease - sugar transport. (279 aa) |
| | ABC-MSP-15 | ABC transporter membrane-spanning permease - sugar transport. (298 aa) |
| | PTS-EII-15 | Phosphotransferase system sugar-specific EII component. (510 aa) |
| | ABC-MSP-16 | ABC transporter membrane-spanning permease - sugar transport. (277 aa) |
| | ABC-MSP-17 | ABC transporter membrane-spanning permease - sugar transport. (294 aa) |
| | secA | Preprotein translocase secA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (837 aa) |
| | natB | ABC transporter membrane-spanning permease - Na+ export. (399 aa) |
| | spr1564 | Hypothetical protein. (205 aa) |
| | scrA | Phosphotransferase system enzyme II. (627 aa) |
| | spr1575 | Hypothetical protein. (149 aa) |
| | spr1576 | Conserved hypothetical protein. (252 aa) |
| | pkn2 | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] (659 aa) |
| | rny | Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (537 aa) |
| | spr1597 | Hypothetical protein. (201 aa) |
| | dctA | Dicarboxylate/amino acid:cation (Na+ or H+) symporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (319 aa) |
| | ABC-MSP-18 | ABC transporter membrane-spanning permease - sugar transport. (284 aa) |
| | ABC-MSP-19 | ABC transporter membrane-spanning permease - sugar transporter. (302 aa) |
| | pilD | Type 4 prepilin peptidase. (219 aa) |
| | mgtC | Mg(2+) transport ATPase/permease. (236 aa) |
| | ABC-MSP-20 | ABC transporter membrane-spanning permease - unknown substrate. (563 aa) |
| | ABC-NBD-26 | ABC transporter ATP-binding protein - unknown substrate; Belongs to the ABC transporter superfamily. (336 aa) |
| | spr1658 | Conserved hypothetical protein. (176 aa) |
| | pbuX | Nucleobase:cation symporter for xanthine. (420 aa) |
| | czcD | Cation diffusion facilitator transporter - heavy metal transport. (299 aa) |
| | proWX | ABC transporter membrane-spanning permease - choline transporter. (506 aa) |
| | fatD | ABC transporter membrane-spanning permease - ferric iron transport; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (324 aa) |
| | fatC | ABC transporter membrane-spanning permease - ferric iron transport; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily. (318 aa) |
| | spr1688 | Conserved hypothetical protein; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. (80 aa) |
| | spr1697 | Hypothetical protein. (100 aa) |
| | treP | Phosphotransferase system, trehalose-specific IIBC component. (705 aa) |
| | amiE | ABC transporter ATP-binding protein - oligopeptide transport; Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. (355 aa) |
| | amiD | ABC transporter membrane-spanning permease - oligopeptide transport; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (308 aa) |
| | amiC | ABC transporter membrane-spanning permease - oligopeptide transport; Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily. (498 aa) |
| | amiA | ABC transporter substrate-binding protein - oligopeptide transport. (659 aa) |
| | msmG | ABC transporter membrane spanning permease - multiple sugars. (277 aa) |
| | msmF | ABC transporter membrane-spanning permease - multiple sugars. (296 aa) |
| | hlyX | Hemolysin. (443 aa) |
| | endA | DNA-entry nuclease (competence-specific nuclease); By degrading DNA that enters the cell, plays a role in the competence of cells to be transformed; Belongs to the DNA/RNA non-specific endonuclease family. (274 aa) |
| | spr1787 | Conserved hypothetical protein; Putative transmembrane protein; Belongs to the BI1 family. (235 aa) |
| | yidC1 | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily. (308 aa) |
| | spr1816 | Conserved hypothetical protein. (255 aa) |
| | pbp2a | Penicillin-binding protein 2a. (731 aa) |
| | spr1826 | Conserved hypothetical protein. (326 aa) |
| | ptcC | Phosphotransferase system system, cellobiose-specific IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (431 aa) |
| | YajC | Conserved hypothetical protein. (99 aa) |
| | PTS-EII-18 | Phosphotransferase system sugar-specific EII component. (508 aa) |
| | yidC2 | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily. (276 aa) |
| | cglB | Competence induced; comG-like protein B. (363 aa) |
| | phoR | Histidine kinase. (443 aa) |
| | pstS-2 | ABC transporter substrate-binding protein - phosphate transport; Part of the ABC transporter complex PstSACB involved in phosphate import. (312 aa) |
| | pstC-2 | ABC transporter membrane-spanning permease - phosphate transport; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (287 aa) |
| | pstA-2 | ABC transporter membrane-spanning permease - phosphate transport. (271 aa) |
| | pstB-3 | ABC transporter ATP-binding protein - phosphate transport; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (250 aa) |
| | ctpC | P-type ATPase - metal/cation transport. (690 aa) |
| | malX | ABC transporter substrate-binding protein - maltose/maltodextrin; Binding protein for maltose and maltodextrin; involved in its cellular uptake. (423 aa) |
| | malC | ABC transporter membrane-spanning permease - maltose/maltodextrin; Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane. (435 aa) |
| | malD | ABC transporter membrane-spanning permease - maltose/maltodextrin; Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane. (287 aa) |
| | spr1923 | Conserved hypothetical protein. (313 aa) |
| | spr1932 | Conserved hypothetical protein; Putative permease. (415 aa) |
| | UlaA | Conserved hypothetical protein; Putative transporter. (448 aa) |
| | spr1959 | Conserved hypothetical integral membrane protein. (503 aa) |
| | spr1962 | Conserved hypothetical protein; Probable member of SPFH domain/Band 7 family. (299 aa) |
| | PTS-EII-19 | Phosphotransferase system sugar-specific EII component. (266 aa) |
| | PTS-EII-20 | Phosphotransferase system sugar-specific EII component. (257 aa) |
| | adcA | ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family. (501 aa) |
| | adcB | ABC transporter membrane-spanning permease - Zinc (Zn2+) transport. (278 aa) |
| | adcC | ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity). (234 aa) |
| | dltD | D-alanine transfer from undecaprenol-phosphate to the poly(glycerophosphate) chain. (427 aa) |
| | dltB | D-alanine transfer from Dcp to undecaprenol-phosphate; Could be involved in the transport of activated D-alanine through the membrane. (414 aa) |
| | spr1983 | Conserved hypothetical protein. (392 aa) |
| | glpF-2 | Glycerol uptake facilitator protein; Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity). (234 aa) |
| | ABC-MSP-21 | ABC transporter membrane-spanning permease - unknown substrate. (253 aa) |
| | spr2010 | Conserved hypothetical protein; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (657 aa) |
| | mreD | Cell-shape determining protein MreD. (164 aa) |
| | mreC | Cell shape determining protein MreC; Involved in formation and maintenance of cell shape. (272 aa) |
| | ABC-MSP-22 | ABC transporter membrane-spanning permease - unknown substrate; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (264 aa) |
| | ABC-NBP | ABC transporter ATP-binding protein - unknown substrate; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (279 aa) |
| | stpA | ABC transporter ATP-binding protein - unknown substrate; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (275 aa) |
| | spr2028 | Conserved hypothetical protein. (276 aa) |
| | sphtra | Serine protease. (397 aa) |
