STRINGSTRING
spr1842 spr1842 nadC nadC rpmG-2 rpmG-2 rpmH rpmH rnmV rnmV lysA lysA spr1744 spr1744 spr1727 spr1727 treP treP czcD czcD cshA cshA trxA trxA spr1594 spr1594 nadD nadD priA priA spr1574 spr1574 IS1381-4 IS1381-4 mvaS mvaS mvaA mvaA scrA scrA dnaB dnaB dnaI dnaI nanA nanA nanB nanB PTS-EII-15 PTS-EII-15 spr1522 spr1522 recR recR spr1506 spr1506 dtd dtd hk01 hk01 rpsO rpsO ctpE ctpE truA truA murT murT cshA-2 cshA-2 spr1433 spr1433 aldR aldR spr1411 spr1411 spr1190 spr1190 pacL pacL rpsF rpsF rpsR rpsR spr1392 spr1392 snf snf spr1372 spr1372 spr1368 spr1368 spr1356 spr1356 DEAD/H DEAD/H pdx1 pdx1 ogt ogt rpsC rpsC rplV rplV rpsS rpsS rplB rplB rplW rplW rplD rplD rplC rplC rpsJ rpsJ spr0186 spr0186 spr0176 spr0176 rpsD rpsD bgaC bgaC purD purD purF purF spr0039 spr0039 recO recO tadA tadA ychF ychF rpsE rpsE rpmD rpmD rplO rplO adk adk rpmJ rpmJ rpsM rpsM rpsK rpsK rplQ rplQ gldA gldA spr0237 spr0237 rpsL rpsL rpsG rpsG rplM rplM rpsI rpsI kdgK kdgK fni fni cbpG cbpG fabF fabF rpmB rpmB spr0480 spr0480 PTS-EII-12 PTS-EII-12 spr0512 spr0512 mrnC mrnC spr0523 spr0523 rplK rplK rplA rplA ABC-NBD-6 ABC-NBD-6 ccdA ccdA rnz rnz spr0592 spr0592 spr0625 spr0625 lctO lctO comEB comEB spr0664 spr0664 ptsG ptsG rheB rheB rpsP rpsP spr0693 spr0693 gyrB gyrB ezrA ezrA flaR flaR rpsT rpsT parE parE rpsA rpsA ABC-NBD-13 ABC-NBD-13 spr0772 spr0772 spr0775 spr0775 spr0783 spr0783 spr0786 spr0786 spr0788 spr0788 spr0801 spr0801 spr0814 spr0814 nspC nspC spr0839 spr0839 IS1381 IS1381 IS1381-2 IS1381-2 spr0851 spr0851 rpmI rpmI rplT rplT ybeY ybeY dgkA dgkA rpmG rpmG ccdA-2 ccdA-2 hemH hemH spr0927 spr0927 spr0940 spr0940 spr0946 spr0946 dnaG dnaG spr0993 spr0993 IS1381-3 IS1381-3 radC radC nifS nifS spr1010 spr1010 rplU rplU rpmA rpmA mreA mreA hlpA hlpA RbgA RbgA acoB acoB acoA acoA spr1078 spr1078 spr1079 spr1079 recN recN ispA ispA udK udK spr1093 spr1093 spr1095 spr1095 spr1096 spr1096 vicX vicX fhs fhs smc smc spr1136 spr1136 spr1137 spr1137 cutC cutC topA topA nth nth spr1169 spr1169 rplS rplS spr1176 spr1176 rpmE rpmE rplF rplF rpsH rpsH rpsN rpsN rplE rplE rplX rplX rplN rplN rpsQ rpsQ rpmC rpmC rplP rplP rplR rplR spo0J spo0J imdH imdH recF recF rpsB rpsB hpf hpf dnaC dnaC spr1994 spr1994 spr1985 spr1985 spr1984 spr1984 fucA fucA spr1954 spr1954 spr1952 spr1952 spr1951 spr1951 IS1381-6 IS1381-6 spr1946 spr1946 rpmG3 rpmG3 rpmF rpmF tktN tktN tyrS tyrS hipO hipO spr1904 spr1904 IS1381-5 IS1381-5 spr1879 spr1879 ackA ackA araD araD spr1197 spr1197 spr1209 spr1209 rplL rplL rplJ rplJ pheA pheA rpsU rpsU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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spr1842Conserved hypothetical protein. (363 aa)
nadCProbable nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (299 aa)
rpmG-250S Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (50 aa)
rpmH50S Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
rnmVConserved hypothetical protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (186 aa)
lysADiaminopimelate decarboxylase. (416 aa)
spr1744Degenerate transposase (orf1). (43 aa)
spr1727Conserved hypothetical protein; Similar to thioredoxin H1. (105 aa)
trePPhosphotransferase system, trehalose-specific IIBC component. (705 aa)
czcDCation diffusion facilitator transporter - heavy metal transport. (299 aa)
cshAChromosome segregation helicase. (423 aa)
trxAThioredoxin reductase; Belongs to the thioredoxin family. (104 aa)
spr1594Conserved hypothetical protein; Similar to GTP-binding protein. (368 aa)
nadDConserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (209 aa)
priAPrimosomal replication factor Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (798 aa)
spr1574Degenerate transposase (orf1). (66 aa)
IS1381-4Tranposase (orf2). (129 aa)
mvaS3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase. (398 aa)
mvaA3-hydroxy-3-methylglutaryl-coenzyme a reductase; Belongs to the HMG-CoA reductase family. (424 aa)
scrAPhosphotransferase system enzyme II. (627 aa)
dnaBChromosome replication initiation protein/membrane attachment protein, Putative. (389 aa)
dnaIPrimosome component (helicase loader). (298 aa)
nanASialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family. (1035 aa)
nanBSialidase B precursor (neuraminidase B). (697 aa)
PTS-EII-15Phosphotransferase system sugar-specific EII component. (510 aa)
spr1522Hypothetical protein. (154 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation ; Belongs to the RecR family. (198 aa)
spr1506Conserved hypothetical protein. (283 aa)
dtdConserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (147 aa)
hk01Histidine kinase. (324 aa)
rpsO30S Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa)
ctpEP-type ATPase - metal cation transport. (778 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (249 aa)
murTConserved hypothetical protein; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. Belongs to the MurCDEF family. MurT subfamily. (447 aa)
cshA-2Conserved hypothetical protein; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (524 aa)
spr1433Conserved hypothetical protein. (225 aa)
aldRTranscription regulator. (126 aa)
spr1411Conserved hypothetical protein; Probable cation transporter; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (394 aa)
spr1190Hypothetical protein. (472 aa)
pacLP-type ATPase - calcium transporter; Putative calcium transporter. (898 aa)
rpsF30S Ribosomal protein S6 (S6); Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsR30S Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa)
spr1392Conserved hypothetical protein; Similar to general stress protein GSP13 from Lactococcus lactis subsp. lactis and Bacillus subtilis. (128 aa)
snfSWF/SNF family ATP-dependent RNA helicase. (1032 aa)
spr1372Hypothetical protein; N-terminal acetyltransferase related protein. (154 aa)
spr1368Hypothetical protein. (160 aa)
spr1356Conserved hypothetical protein. (414 aa)
DEAD/HDEAD RNA helicase. (360 aa)
pdx1Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (297 aa)
ogtO6-methylguanine-DNA methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (176 aa)
rpsC30S Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (217 aa)
rplV50S Ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (114 aa)
rpsS30S Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplB50S Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rplW50S Ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplD50S Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (207 aa)
rplC50S Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (208 aa)
rpsJ30S Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
spr0186Hypothetical protein. (205 aa)
spr0176Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. (139 aa)
rpsD30S Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa)
bgaCBeta-galactosidase 3; Belongs to the glycosyl hydrolase 35 family. (595 aa)
purDPhosphoribosylglycinamide synthetase. (420 aa)
purFAmidophosphoribosyl transferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (480 aa)
spr0039Degenerate transposase (orf2). (97 aa)
recOConserved hypothetical protein; Involved in DNA repair and RecF pathway recombination (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation ; Belongs to the RecO family. (256 aa)
tadAConserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (155 aa)
ychFConserved hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (371 aa)
rpsE30S Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (164 aa)
rpmD50S Ribosomal protein L30. (60 aa)
rplO50S Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
adkAdenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
rpmJ50S Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa)
rpsM30S Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
rpsK30S Ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa)
rplQ50S Ribosomal protein L17. (128 aa)
gldAGlycerol dehydrogenase, NAD+ dependent. (362 aa)
spr0237Conserved hypothetical protein; Similar to histone acetyltransferase HPA2 and related acetyltransferases. (138 aa)
rpsL30S Ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (137 aa)
rpsG30S Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rplM50S Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa)
rpsI30S Ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
kdgK2-keto-3-deoxygluconate kinase. (333 aa)
fniIsopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (336 aa)
cbpGCholine binding protein G. (42 aa)
fabFBeta ketoacyl-acyl carrier protein synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa)
rpmB50S Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa)
spr0480Conserved hypothetical protein; Probable ribosomal protein. (99 aa)
PTS-EII-12Phosphotransferase system sugar-specific EII component. (612 aa)
spr0512Degenerate transposase. (42 aa)
mrnCConserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (128 aa)
spr0523Transposase, uncharacterized, truncation. (57 aa)
rplK50S Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplA50S Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
ABC-NBD-6ABC transporter ATP-binding protein - role in polysaccharide efflux. (330 aa)
ccdACytochrome c-type biogenesis protein. (236 aa)
rnzConserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (309 aa)
spr0592Conserved hypothetical protein; Probable oxidoreductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
spr0625Lactate oxidase, truncation. (48 aa)
lctOLactate oxidase. (378 aa)
comEBdCMP deaminase; Putative late competence operon required for DNA binding and uptake. (155 aa)
spr0664Conserved hypothetical protein. (218 aa)
ptsGPTS glucose-specific enzyme IIABC component. (726 aa)
rheBATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa)
rpsP30S Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (90 aa)
spr0693Conserved hypothetical protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (399 aa)
gyrBDNA gyrase; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (648 aa)
ezrACell division regulator, negative regulator of FtsZ ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (584 aa)
flaRModulates DNA topology. (174 aa)
rpsT30S Ribosomal protein subunit S20; Binds directly to 16S ribosomal RNA. (83 aa)
parETopoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (647 aa)
rpsA30S Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity); Belongs to the bacterial ribosomal protein bS1 family. (400 aa)
ABC-NBD-13ABC transporter ATP-binding protein - unknown substrate. (263 aa)
spr0772Conserved hypothetical protein. (420 aa)
spr0775Conserved hypothetical protein. (470 aa)
spr0783Probable pyridoxal-phosphate dependent aminotransferase. (380 aa)
spr0786Hypothetical protein. (111 aa)
spr0788Hypothetical protein. (135 aa)
spr0801Degenerate transposase (orf1). (62 aa)
spr0814Conserved hypothetical protein. (196 aa)
nspCCarboxynorspermidine decarboxylase. (375 aa)
spr0839Conserved hypothetical protein. (181 aa)
IS1381Tranposase (orf2). (129 aa)
IS1381-2Tranposase (orf1). (129 aa)
spr0851Hypothetical protein. (75 aa)
rpmI50S Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa)
rplT50S Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (165 aa)
dgkADiacylglycerol kinase. (131 aa)
rpmG50S Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
ccdA-2Cytochrome c-type biogenesis protein. (235 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (364 aa)
spr0927Conserved hypothetical protein. (156 aa)
spr0940Hypothetical protein. (51 aa)
spr0946Conserved hypothetical protein; Putative hydrolase. (284 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (591 aa)
spr0993Degenerate transposase (orf1). (235 aa)
IS1381-3Tranposase (orf2). (129 aa)
radCDNA repair protein. (231 aa)
nifSPyridoxal-phosphate dependent aminotransferase. (371 aa)
spr1010Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa)
rplU50S Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa)
rpmA50S Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (89 aa)
mreAMacrolide-efflux protein; Belongs to the ribF family. (305 aa)
hlpAHistone-like DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (91 aa)
RbgAConserved hypothetical protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (283 aa)
acoBTPP-dependent acetoin dehydrogenase beta chain. (330 aa)
acoATPP-dependent acetoin dehydrogenase alpha chain. (322 aa)
spr1078Degenerate transposase (orf2). (132 aa)
spr1079Degenerate transposase (orf1). (173 aa)
recNDNA repair and genetic recombination; May be involved in recombinational repair of damaged DNA. (555 aa)
ispAFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (291 aa)
udKUridine kinase. (212 aa)
spr1093Conserved hypothetical protein. (1061 aa)
spr1095O-acetylhomoserine sulfhydrylase, truncation. (371 aa)
spr1096O-acetylhomoserine sulfhydrylase, truncation. (40 aa)
vicXVicX protein. (269 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
smcChromosome condensation and segregation SMC protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1179 aa)
spr11362-isopropylmalate synthase, truncation; Belongs to the alpha-IPM synthase/homocitrate synthase family. (144 aa)
spr11372-isopropylmalate synthase, truncation. (210 aa)
cutCCopper sensitivity; Participates in the control of copper homeostasis. Belongs to the CutC family. (210 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (701 aa)
nthEndonuclease III (DNA repair); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (209 aa)
spr1169Conserved hypothetical protein. (466 aa)
rplS50S Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa)
spr1176Conserved hypothetical protein. (315 aa)
rpmE50S ribosomal protein L31. (80 aa)
rplF50S Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa)
rpsH30S Ribosomal protein S8 (S8); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsN30S Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa)
rplE50S Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rplX50S Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (101 aa)
rplN50S Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa)
rpmC50S Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rplP50S Ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa)
rplR50S Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa)
spo0JChromosome segregation protein; Belongs to the ParB family. (252 aa)
imdHInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (492 aa)
recFRecombination protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation. (365 aa)
rpsB30S Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (259 aa)
hpfConserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (182 aa)
dnaCReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
spr1994Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (336 aa)
spr1985Transposase, uncharacterized, truncation. (93 aa)
spr1984Transposase, uncharacterized, truncation. (330 aa)
fucAL-fuculose phosphate aldolase. (217 aa)
spr1954Hypothetical protein. (583 aa)
spr1952Conserved hypothetical protein. (434 aa)
spr1951Conserved hypothetical protein; Probable sugar hydrolase. (886 aa)
IS1381-6Tranposase (orf2). (129 aa)
spr1946Degenerate transposase (orf1). (189 aa)
rpmG350S Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
rpmF50S Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
tktNPutative transketolase n-terminal section. (285 aa)
tyrSTyrosyl-tRNA synthetase 1; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa)
hipOSimilar to several hippurate hydrolases and amino acid amidohydrolases; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (376 aa)
spr1904Conserved hypothetical protein. (226 aa)
IS1381-5Tranposase (orf2). (129 aa)
spr1879Hypothetical protein. (425 aa)
ackAAcetate kinase (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (396 aa)
araDL-ribulose 5-phosphate 4-epimerase. (234 aa)
spr1197Degenerate transposase (orf2). (87 aa)
spr1209Hypothetical protein. (84 aa)
rplL50S Ribosomal protein L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (127 aa)
rplJ50S Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa)
pheAPrephenate dehydratase. (282 aa)
rpsU30S Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (66 aa)
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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