(7 nodes) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain network (Thermococcus piezophilus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANF22127.1	Indolepyruvate ferredoxin oxidoreductase subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (648 aa)
	ANF22579.1	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
	ANF22582.1	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
	ANF22775.1	Indolepyruvate ferredoxin oxidoreductase subunit alpha; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (635 aa)
	ANF23279.1	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
	ANF23282.1	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)
	ANF23534.1	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)

Your Current Organism:

Thermococcus piezophilus

NCBI taxonomy Id: 1712654
Other names: ATCC TSD-33, T. piezophilus, Thermococcus piezophilus Dalmasso et al. 2017, Thermococcus sp. CDGS, UBOCC 3296, strain CDGS

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANF22579.1	ANF22582.1	A7C91_04880	A7C91_04895	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.724
ANF22579.1	ANF23279.1	A7C91_04880	A7C91_08930	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF22579.1	ANF23282.1	A7C91_04880	A7C91_08945	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF22579.1	ANF23534.1	A7C91_04880	A7C91_10490	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF22582.1	ANF22579.1	A7C91_04895	A7C91_04880	2-ketoisovalerate ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.724
ANF23279.1	ANF22579.1	A7C91_08930	A7C91_04880	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF23279.1	ANF23282.1	A7C91_08930	A7C91_08945	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ANF23279.1	ANF23534.1	A7C91_08930	A7C91_10490	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.908
ANF23282.1	ANF22579.1	A7C91_08945	A7C91_04880	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF23282.1	ANF23279.1	A7C91_08945	A7C91_08930	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
ANF23282.1	ANF23534.1	A7C91_08945	A7C91_10490	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910
ANF23534.1	ANF22579.1	A7C91_10490	A7C91_04880	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyruvate ferredoxin oxidoreductase; Catalyzes the formation of acetyl-CoA from pyruvate and coenzyme A; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.900
ANF23534.1	ANF23279.1	A7C91_10490	A7C91_08930	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.908
ANF23534.1	ANF23282.1	A7C91_10490	A7C91_08945	2-oxoacid ferredoxin oxidoreductase; Catalyzes the coenzyme A-dependent decarboxylation of 2-oxoacids, such as pyruvate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology.	2-oxoglutarate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.910

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Databases

Cooccurrence

Experiments

Fusion

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About