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leuB leuB leuA leuA ilvC ilvC ilvH ilvH ilvI ilvI sucD sucD sucC sucC idh idh acnA acnA aclA aclA aclB aclB forA forA forC forC forB forB CUQ65590.1 CUQ65590.1 ackA ackA CUQ65682.1 CUQ65682.1 leuC leuC leuD leuD gcvT gcvT CUQ65908.1 CUQ65908.1 prpC prpC prpB prpB prpD prpD paaF paaF argK argK mvaB mvaB CUQ65915.1 CUQ65915.1 pccB pccB mmgB mmgB atoB atoB CUQ65922.1 CUQ65922.1 CUQ65923.1 CUQ65923.1 CUQ65924.1 CUQ65924.1 CUQ65926.1 CUQ65926.1 CUQ65927.1 CUQ65927.1 CUQ65928.1 CUQ65928.1 CUQ65929.1 CUQ65929.1 CUQ65930.1 CUQ65930.1 CUQ65931.1 CUQ65931.1 mdh mdh gcvP gcvP purU purU CUQ66112.1 CUQ66112.1 gdhA gdhA lipB lipB ilvE ilvE sdhC sdhC sdhA-2 sdhA-2 sdhB sdhB CUQ66452.1 CUQ66452.1 CUQ66453.1 CUQ66453.1 porE porE porC porC porB porB porA porA glnA glnA CUQ66890.1 CUQ66890.1 ppdK ppdK acsA acsA fumC fumC CUQ67175.1 CUQ67175.1 CUQ67176.1 CUQ67176.1 pycB pycB pycA pycA CUQ67179.1 CUQ67179.1 lipA lipA maeB maeB gltA gltA gcvH gcvH lpd lpd ilvD ilvD accA accA CUQ67702.1 CUQ67702.1 accC accC accB accB accD accD ilvE-2 ilvE-2 acyP acyP gltD gltD gltB gltB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (357 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ilvHAcetolactate synthase III, thiamin-dependent, small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (172 aa)
ilvIAcetolactate synthase III, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (591 aa)
sucDsuccinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (392 aa)
idhIsocitrate dehydrogenase (NADP(+)); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the monomeric-type IDH family. (743 aa)
acnAAconitate hydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (748 aa)
aclAATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (606 aa)
aclBATP-citrate lyase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (399 aa)
forA2-oxoglutarate:ferredoxin oxidoredutase alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (444 aa)
forC2-oxoglutarate:ferredoxin oxidoredutase gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (239 aa)
forB2-oxoglutarate:ferredoxin oxidoredutase beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (300 aa)
CUQ65590.1Putative Acyl-CoA synthetase (NDP forming) (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (726 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (421 aa)
CUQ65682.1Putative phosphoketolase 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (796 aa)
leuC3-isopropylmalate dehydratase (isomerase), subunit with LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
leuD3-isopropylmalate isomerase subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (206 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
CUQ65908.1Putative 2-succinylbenzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (573 aa)
prpC2-methylcitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (386 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (307 aa)
prpD2-methylcitrate dehydratase. (479 aa)
paaFenoyl-CoA hydratase-isomerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
argKLAO/AO transport system ATPase. (266 aa)
mvaBHydroxymethylglutaryl-CoA lyase. (322 aa)
CUQ65915.1Putative Enoyl-CoA hydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (267 aa)
pccBPropionyl-CoA carboxylase. (533 aa)
mmgBPutative 3-hydroxybutyryl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme;fragment of methylmalonyl-CoA mutase (part 1). (296 aa)
atoBAcetyl-CoA acetyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
CUQ65922.1Branched-chain alpha-keto acid dehydrogenase, dihydrolipoamide acyltransferase (E2) component; Function of strongly homologous gene; enzyme. (401 aa)
CUQ65923.1Putative Pyruvate dehydrogenase E1 component, subunit beta; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa)
CUQ65924.1Putative Pyruvate dehydrogenase E1 component, subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (333 aa)
CUQ65926.1Putative Fumarylacetoacetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (327 aa)
CUQ65927.1Putative dioxygenase VC_1345; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (369 aa)
CUQ65928.1Putative 4-hydroxyphenylpyruvate dioxygenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (194 aa)
CUQ65929.1Homologs of previously reported genes of unknown function. (242 aa)
CUQ65930.1Homologs of previously reported genes of unknown function. (320 aa)
CUQ65931.1Putative Acyl-CoA dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (659 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (340 aa)
gcvPGlycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (961 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (288 aa)
CUQ66112.1Uncharacterized AIPM/Hcit synthase family transferase TM_0552; Belongs to the alpha-IPM synthase/homocitrate synthase family. (541 aa)
gdhAGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (282 aa)
ilvEPutative branched-chain-amino-acid aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (297 aa)
sdhCSuccinate dehydrogenase/fumarate reductase, cytochrome b558 subunit; Function of strongly homologous gene; enzyme. (226 aa)
sdhA-2Succinate dehydrogenase or fumarate reductase, flavoprotein subunit; Function of strongly homologous gene; enzyme. (638 aa)
sdhBSuccinate dehydrogenase/fumarate reductase, Fe-S protein subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (262 aa)
CUQ66452.1Putative isocitrate dehydrogenase (NADP); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (117 aa)
CUQ66453.1Isocitrate dehydrogenase (NAD+). (338 aa)
porEPyruvate:ferredoxin oxidoreductase, epsilon subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (92 aa)
porCPyruvate:ferredoxin oxidoreductase, gamma subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (235 aa)
porBPyruvate:ferredoxin oxidoreductase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (302 aa)
porAPyruvate:ferredoxin oxidoreductase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (403 aa)
glnAGlutamine synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (469 aa)
CUQ66890.1Putative Aminomethyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the GcvT family. (363 aa)
ppdKPyruvate, phosphate dikinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the PEP-utilizing enzyme family. (922 aa)
acsAAcetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (629 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (479 aa)
CUQ67175.1Putative Thiol peroxidase (Modular protein); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. (221 aa)
CUQ67176.1Putative 2-hydroxy-6-ketonona-2,4-dienedioate hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (333 aa)
pycBPyruvate carboxylase, subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (649 aa)
pycAPyruvate carboxylase, subunit A; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (486 aa)
CUQ67179.1Homologs of previously reported genes of unknown function. (320 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (313 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (482 aa)
gltACitrate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the citrate synthase family. (377 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
lpdDihydrolipoyl dehydrogenase, E3 component of Pyruvate and 2-oxoglutarate dehydrogenase complexes; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (477 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (557 aa)
accAacetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (321 aa)
CUQ67702.1Putative Biotin-(Acetyl-CoA-carboxylase) ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (279 aa)
accCacetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
accBAcetyl CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (186 aa)
accDacetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (278 aa)
ilvE-2Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (304 aa)
acyPAcylphosphatase; Function of strongly homologous gene; enzyme. (98 aa)
gltDGlutamate synthase [NADPH] small chain. (478 aa)
gltBGlutamate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1505 aa)
Your Current Organism:
Nitrospira inopinata
NCBI taxonomy Id: 1715989
Other names: C. Nitrospira inopinata, Candidatus Nitrospira inopinata, Nitrospira sp. ENR4
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