STRINGSTRING
fabG-4 fabG-4 asd asd ilvC ilvC rkpK rkpK CUQ65137.1 CUQ65137.1 CUQ65152.1 CUQ65152.1 fabG fabG fabG-2 fabG-2 sucD sucD aclA aclA folD folD fabG-3 fabG-3 proC proC dfrA dfrA hldD hldD CUQ65392.1 CUQ65392.1 CUQ65398.1 CUQ65398.1 adhC adhC CUQ65534.1 CUQ65534.1 CUQ65590.1 CUQ65590.1 zwf zwf hom hom fabI fabI mmgB mmgB mdh mdh CUQ66104.1 CUQ66104.1 gpsA gpsA dapB dapB gdhA gdhA xecD xecD aroE aroE CUQ66379.1 CUQ66379.1 CUQ66522.1 CUQ66522.1 ahcY ahcY CUQ66621.1 CUQ66621.1 CUQ66625.1 CUQ66625.1 adhA adhA tdh tdh CUQ66638.1 CUQ66638.1 dxr dxr zwf-2 zwf-2 yqeC yqeC CUQ67057.1 CUQ67057.1 CUQ67077.1 CUQ67077.1 rfbG rfbG CUQ67228.1 CUQ67228.1 maeB maeB CUQ67363.1 CUQ67363.1 CUQ67387.1 CUQ67387.1 CUQ67388.1 CUQ67388.1 CUQ67398.1 CUQ67398.1 capL capL argC argC hemA hemA fabG-5 fabG-5 tiaE tiaE CUQ67596.1 CUQ67596.1 serA serA CUQ67661.1 CUQ67661.1 CUQ67695.1 CUQ67695.1 CUQ67704.1 CUQ67704.1 CUQ67835.1 CUQ67835.1 CUQ67859.1 CUQ67859.1 CUQ67880.1 CUQ67880.1 CUQ68000.1 CUQ68000.1 rfbD rfbD epsC epsC CUQ68067.1 CUQ68067.1 rmlB rmlB fcl fcl gmd gmd CUQ68103.1 CUQ68103.1 gapA gapA galE galE ald ald
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
fabG-43-oxoacyl-(Acyl-carrier-protein) reductase. (265 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (339 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
rkpKUDP-glucose 6-dehydrogenase. (441 aa)
CUQ65137.1Uncharacterized oxidoreductase MexAM1_META1p0182. (243 aa)
CUQ65152.1Homologs of previously reported genes of unknown function. (285 aa)
fabG3-oxoacyl-(Acyl-carrier-protein) reductase. (244 aa)
fabG-23-oxoacyl-[acyl-carrier-protein] reductase FabG. (241 aa)
sucDsuccinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
aclAATP citrate lyase, alpha subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (606 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
fabG-33-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa)
dfrAPutative dihydroflavonol-4-reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (327 aa)
hldDADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (338 aa)
CUQ65392.1GroES-like protein. (731 aa)
CUQ65398.1Homologs of previously reported genes of unknown function. (391 aa)
adhCAlcohol dehydrogenase, NADP-dependent; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (347 aa)
CUQ65534.1Zn-dependent alcohol dehydrogenase. (338 aa)
CUQ65590.1Putative Acyl-CoA synthetase (NDP forming) (fragment); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (726 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (455 aa)
homHomoserine dehydrogenase. (437 aa)
fabIEnoyl-[acyl-carrier-protein] reductase [NADH] FabI. (259 aa)
mmgBPutative 3-hydroxybutyryl-CoA dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme;fragment of methylmalonyl-CoA mutase (part 1). (296 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (340 aa)
CUQ66104.1Homologs of previously reported genes of unknown function. (322 aa)
gpsAGlycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (267 aa)
gdhAGlutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (418 aa)
xecD2-(R)-hydroxypropyl-CoM dehydrogenase. (253 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (284 aa)
CUQ66379.1Putative UDP-glucose 4-epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (305 aa)
CUQ66522.1Putative Histidine kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (382 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (418 aa)
CUQ66621.1Putative Glutathione-regulated potassium-efflux system; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. (669 aa)
CUQ66625.1Uncharacterized 37.6 kDa protein in cld 5'region. (340 aa)
adhAPutative alcohol dehydrogenase AdhA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (336 aa)
tdhThreonine 3-dehydrogenase, NAD(P)-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (344 aa)
CUQ66638.1Putative Histidine kinase with N-terminal NAD-binding region; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (377 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (386 aa)
zwf-2Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (518 aa)
yqeCPutative 6-phosphogluconate dehydrogenase YqeC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (297 aa)
CUQ67057.1Putative Saccharopine dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (384 aa)
CUQ67077.1Putative Oxidoreductase, GFO/IDH/MOCA family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (346 aa)
rfbGCDP-glucose 4,6-dehydratase. (359 aa)
CUQ67228.1NAD-dependent epimerase/dehydratase. (302 aa)
maeBMalate dehydrogenase (oxaloacetate-decarboxylating); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (482 aa)
CUQ67363.1Putative Undecaprenyl-phosphate galactose phosphotransferase RfbP; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (350 aa)
CUQ67387.1Putative chlorophyll synthesis pathway protein BchC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (371 aa)
CUQ67388.1Homologs of previously reported genes of unknown function. (350 aa)
CUQ67398.1Dehydrogenase and related protein-like protein. (678 aa)
capLProtein CapL; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (431 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (350 aa)
hemAGlutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (458 aa)
fabG-53-oxoacyl-(Acyl-carrier-protein) reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (242 aa)
tiaE2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase); Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
CUQ67596.1Putative NAD-dependent epimerase/dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (277 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (537 aa)
CUQ67661.1Homologs of previously reported genes of unknown function. (362 aa)
CUQ67695.12-dehydropantoate 2-reductase. (454 aa)
CUQ67704.1Oxidoreductase, Glucose/ribitol dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (289 aa)
CUQ67835.1Oxidoreductase, zinc-binding dehydrogenase family. (334 aa)
CUQ67859.1Putative Precorrin-2 dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (217 aa)
CUQ67880.1Putative NAD-dependent alcohol dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (342 aa)
CUQ68000.1NAD-dependent epimerase/dehydratase. (253 aa)
rfbDdTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (280 aa)
epsCPutative polysaccharide biosynthesis protein EpsC; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (649 aa)
CUQ68067.1NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase. (336 aa)
rmlBdTDP-glucose 4,6 dehydratase, NAD(P)-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (384 aa)
fclGDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (318 aa)
gmdGDP-D-mannose dehydratase, NAD(P)-binding; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (341 aa)
CUQ68103.1Putative Oxidoreductase, Gfo/Idh/MocA family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (334 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa)
galEUDP-galactose-4-epimerase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (341 aa)
aldAlanine dehydrogenase; Belongs to the AlaDH/PNT family. (367 aa)
Your Current Organism:
Nitrospira inopinata
NCBI taxonomy Id: 1715989
Other names: C. Nitrospira inopinata, Candidatus Nitrospira inopinata, Nitrospira sp. ENR4
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