node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOT82_1697 | AOT82_962 | AOT82_1697 | AOT82_962 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.823 |
AOT82_1697 | hemA | AOT82_1697 | AOT82_1592 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.460 |
AOT82_1697 | hemC | AOT82_1697 | AOT82_1698 | Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.972 |
AOT82_1849 | AOT82_2216 | AOT82_1849 | AOT82_2216 | Oxygen-independent coproporphyrinogen III oxidase. | Hypothetical protein. | 0.912 |
AOT82_1849 | hemE | AOT82_1849 | AOT82_2734 | Oxygen-independent coproporphyrinogen III oxidase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.948 |
AOT82_1849 | hemF | AOT82_1849 | AOT82_1519 | Oxygen-independent coproporphyrinogen III oxidase. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.948 |
AOT82_1849 | hemH | AOT82_1849 | AOT82_1328 | Oxygen-independent coproporphyrinogen III oxidase. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.444 |
AOT82_2216 | AOT82_1849 | AOT82_2216 | AOT82_1849 | Hypothetical protein. | Oxygen-independent coproporphyrinogen III oxidase. | 0.912 |
AOT82_2216 | hemF | AOT82_2216 | AOT82_1519 | Hypothetical protein. | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. | 0.941 |
AOT82_2216 | hemH | AOT82_2216 | AOT82_1328 | Hypothetical protein. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.925 |
AOT82_2256 | AOT82_2257 | AOT82_2256 | AOT82_2257 | Hypothetical protein. | Hypothetical protein. | 0.603 |
AOT82_2257 | AOT82_2256 | AOT82_2257 | AOT82_2256 | Hypothetical protein. | Hypothetical protein. | 0.603 |
AOT82_2261 | AOT82_2262 | AOT82_2261 | AOT82_2262 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Hypothetical protein. | 0.625 |
AOT82_2261 | AOT82_2263 | AOT82_2261 | AOT82_2263 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme exporter protein B1; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | 0.997 |
AOT82_2261 | AOT82_2265 | AOT82_2261 | AOT82_2265 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.790 |
AOT82_2261 | AOT82_941 | AOT82_2261 | AOT82_941 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | NrfG protein. | 0.647 |
AOT82_2261 | AOT82_942 | AOT82_2261 | AOT82_942 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme lyase subunit; Possible subunit of a heme lyase. | 0.714 |
AOT82_2261 | AOT82_943 | AOT82_2261 | AOT82_943 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Thiol:disulfide interchange protein. | 0.590 |
AOT82_2261 | AOT82_944 | AOT82_2261 | AOT82_944 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Cytochrome c-type biogenesis protein. | 0.876 |
AOT82_2261 | ccmC | AOT82_2261 | AOT82_2264 | Heme exporter protein A1; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system. | Heme exporter protein C1; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | 0.995 |