node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AOT82_133 | AOT82_1483 | AOT82_133 | AOT82_1483 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.921 |
AOT82_133 | AOT82_722 | AOT82_133 | AOT82_722 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Small (beta) subunit of the fatty acid-oxidizing multienzyme complex; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
AOT82_1483 | AOT82_133 | AOT82_1483 | AOT82_133 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.921 |
AOT82_1483 | AOT82_722 | AOT82_1483 | AOT82_722 | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | Small (beta) subunit of the fatty acid-oxidizing multienzyme complex; Belongs to the thiolase-like superfamily. Thiolase family. | 0.921 |
AOT82_2139 | AOT82_958 | AOT82_2139 | AOT82_958 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | 0.927 |
AOT82_2139 | dxr | AOT82_2139 | AOT82_2701 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 0.450 |
AOT82_2139 | dxs | AOT82_2139 | AOT82_1517 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.526 |
AOT82_2139 | ispE | AOT82_2139 | AOT82_1595 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.434 |
AOT82_2139 | ispH | AOT82_2139 | AOT82_2388 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | LytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. | 0.928 |
AOT82_2139 | uppS | AOT82_2139 | AOT82_2699 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.963 |
AOT82_722 | AOT82_133 | AOT82_722 | AOT82_133 | Small (beta) subunit of the fatty acid-oxidizing multienzyme complex; Belongs to the thiolase-like superfamily. Thiolase family. | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.925 |
AOT82_722 | AOT82_1483 | AOT82_722 | AOT82_1483 | Small (beta) subunit of the fatty acid-oxidizing multienzyme complex; Belongs to the thiolase-like superfamily. Thiolase family. | acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.921 |
AOT82_958 | AOT82_2139 | AOT82_958 | AOT82_2139 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.927 |
AOT82_958 | uppS | AOT82_958 | AOT82_2699 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. | 0.966 |
dxr | AOT82_2139 | AOT82_2701 | AOT82_2139 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. | 0.450 |
dxr | dxs | AOT82_2701 | AOT82_1517 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. | 0.981 |
dxr | ispD | AOT82_2701 | AOT82_1142 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.983 |
dxr | ispE | AOT82_2701 | AOT82_1595 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.836 |
dxr | ispF | AOT82_2701 | AOT82_228 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). | 0.842 |
dxr | ispG | AOT82_2701 | AOT82_2636 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. | 0.841 |