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| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa) |
| | ALV31060.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa) |
| | ALV31112.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa) |
| | ALV38328.1 | Lysine 2,3-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa) |
| | ALV31113.1 | Lysine 2,3-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa) |
| | ALV38333.1 | Peptide synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa) |
| | ALV31131.1 | Decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa) |
| | ALV31132.1 | Methylaspartate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa) |
| | ALV38425.1 | Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa) |
| | ALV31781.1 | Pyridoxal-5'-phosphate-dependent protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa) |
| | ALV31790.1 | Prephenate dehydratase; Catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa) |
| | ALV32182.1 | Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (542 aa) |
| | ALV32355.1 | Saccharopine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa) |
| | ALV32356.1 | Saccharopine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (291 aa) |
| | dapA | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | ALV32998.1 | Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (200 aa) |
| | leuD | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | leuC | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (474 aa) |
| | ALV33325.1 | Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (534 aa) |
| | ALV33331.1 | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (347 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | ALV33344.1 | Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa) |
| | ALV38590.1 | Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (616 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (305 aa) |
| | ALV33499.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (352 aa) |
| | ALV33500.1 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (463 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (438 aa) |
| | ALV33687.1 | Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa) |
| | ALV33751.1 | Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa) |
| | ALV33752.1 | Succinyldiaminopimelate transaminase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa) |
| | ALV33753.1 | Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (105 aa) |
| | ALV33755.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa) |
| | ALV33863.1 | Aminotransferase; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa) |
| | ALV33883.1 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa) |
| | ALV33995.1 | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (733 aa) |
| | ALV34046.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa) |
| | ALV34147.1 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (617 aa) |
| | ALV34428.1 | Isopropylmalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa) |
| | ALV34458.1 | Inhibition of morphological differentiation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (352 aa) |
| | ALV34487.1 | Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (423 aa) |
| | ALV34523.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa) |
| | ALV34653.1 | Aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) |
| | ALV34739.1 | Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa) |
| | ALV35014.1 | Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa) |
| | ALV35298.1 | Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa) |
| | ALV35547.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (562 aa) |
| | aroA-2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (417 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (338 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (354 aa) |
| | ALV36210.1 | Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (626 aa) |
| | ALV36211.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II DAHP synthase family. (450 aa) |
| | hisD-2 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa) |
| | hisC | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (375 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (215 aa) |
| | priA | 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (241 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (130 aa) |
| | trpE | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (492 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (269 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (427 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | ALV36320.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (116 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa) |
| | dapA-2 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa) |
| | ALV36475.1 | Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (578 aa) |
| | ALV38921.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa) |
| | ALV36616.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa) |
| | ALV36617.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa) |
| | ALV36862.1 | Chloride transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa) |
| | ALV36863.1 | 4-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa) |
| | ALV36915.1 | Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the shikimate dehydrogenase family. (271 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (171 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | ALV37523.1 | Peptidase dimerization protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa) |
| | ALV37721.1 | Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa) |
| | ALV37746.1 | ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (404 aa) |
| | ALV37976.1 | Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa) |
| | ALV39097.1 | GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa) |
| | ALV38017.1 | Benzaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (484 aa) |
| | ALV38018.1 | Benzoylformate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (524 aa) |
