STRINGSTRING
pfkA pfkA ALL04121.1 ALL04121.1 ALL04127.1 ALL04127.1 ALL04196.1 ALL04196.1 ALL04210.1 ALL04210.1 ALL04226.1 ALL04226.1 pckA pckA ALL04434.1 ALL04434.1 ALL04442.1 ALL04442.1 ALL04450.1 ALL04450.1 ALL04454.1 ALL04454.1 ALL04539.1 ALL04539.1 ALL04540.1 ALL04540.1 ALL04544.1 ALL04544.1 ALL08644.1 ALL08644.1 ALL04696.1 ALL04696.1 ALL04738.1 ALL04738.1 ALL04833.1 ALL04833.1 pgk pgk ALL04882.1 ALL04882.1 pfkA-2 pfkA-2 ALL04896.1 ALL04896.1 ALL04912.1 ALL04912.1 sdhA sdhA ALL04914.1 ALL04914.1 ALL04944.1 ALL04944.1 ALL05028.1 ALL05028.1 ALL05029.1 ALL05029.1 ALL05030.1 ALL05030.1 ALL05031.1 ALL05031.1 ALL05090.1 ALL05090.1 sucC sucC ALL05133.1 ALL05133.1 ALL05138.1 ALL05138.1 ALL05156.1 ALL05156.1 fbp fbp ALL05528.1 ALL05528.1 ALL05644.1 ALL05644.1 ALL05658.1 ALL05658.1 gltA gltA ALL08731.1 ALL08731.1 ALL05987.1 ALL05987.1 ackA ackA ALL06251.1 ALL06251.1 ALL06252.1 ALL06252.1 ALL06253.1 ALL06253.1 ALL06254.1 ALL06254.1 ALL06255.1 ALL06255.1 ALL06256.1 ALL06256.1 gpmA gpmA ALL06427.1 ALL06427.1 ALL06478.1 ALL06478.1 tal tal ALL06501.1 ALL06501.1 gltD gltD ALL06555.1 ALL06555.1 ALL06646.1 ALL06646.1 ALL07056.1 ALL07056.1 ALL07058.1 ALL07058.1 ALL07059.1 ALL07059.1 ALL08856.1 ALL08856.1 pckA-2 pckA-2 ALL07125.1 ALL07125.1 ALL07134.1 ALL07134.1 mqo mqo ALL07140.1 ALL07140.1 ALL07212.1 ALL07212.1 ALL07326.1 ALL07326.1 tpiA tpiA ALL07557.1 ALL07557.1 ALL07636.1 ALL07636.1 ALL07638.1 ALL07638.1 ALL07741.1 ALL07741.1 gpmI gpmI ALL08022.1 ALL08022.1 ALL08025.1 ALL08025.1 ALL08026.1 ALL08026.1 mdh mdh eno eno sucD sucD ALL08158.1 ALL08158.1 ALL08224.1 ALL08224.1 lipA lipA pgi pgi lipB lipB ALL08446.1 ALL08446.1 sdhA-2 sdhA-2 ALL08448.1 ALL08448.1 ALL08486.1 ALL08486.1 pdhA pdhA fumC fumC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
ALL04121.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (466 aa)
ALL04127.1Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (863 aa)
ALL04196.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (476 aa)
ALL04210.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
ALL04226.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (512 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (534 aa)
ALL04434.1Acylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
ALL04442.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (771 aa)
ALL04450.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
ALL04454.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
ALL04539.12-oxoglutarate dehydrogenase subunit E1; Derived by automated computational analysis using gene prediction method: Protein Homology. (930 aa)
ALL04540.12-oxoglutarate dehydrogenase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (406 aa)
ALL04544.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
ALL08644.1DNA mismatch repair protein MutT; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
ALL04696.1acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (630 aa)
ALL04738.1Phosphoheptose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
ALL04833.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
pgkPhosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (397 aa)
ALL04882.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
pfkA-26-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (328 aa)
ALL04896.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ALL04912.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
ALL04914.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ALL04944.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (473 aa)
ALL05028.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (124 aa)
ALL05029.1Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
ALL05030.1Catalyzes the oxidation of acetaldehyde, benzaldehyde, propionaldehyde and other aldehydes; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
ALL05031.1AraC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
ALL05090.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
ALL05133.1Glyceraldehyde-3-phosphate dehydrogenase; Catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; involved in growth under gluconeogenic conditions and in glycolytic activity at high ATP concentrations in Corynebacterium; NAD and NADP dependent; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (482 aa)
ALL05138.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ALL05156.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (728 aa)
fbpFructose 1,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (351 aa)
ALL05528.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (342 aa)
ALL05644.1Ribulose phosphate epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (222 aa)
ALL05658.1Diapophytoene dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
ALL08731.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ALL05987.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (397 aa)
ALL06251.1Phosphoketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (786 aa)
ALL06252.1ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (899 aa)
ALL06253.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (78 aa)
ALL06254.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
ALL06255.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ALL06256.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (244 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (200 aa)
ALL06427.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
ALL06478.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
talFructose-6-phosphate aldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (221 aa)
ALL06501.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1501 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
ALL06555.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
ALL06646.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (541 aa)
ALL07056.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ALL07058.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (140 aa)
ALL07059.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetokinase family. (193 aa)
ALL08856.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (411 aa)
pckA-2Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (521 aa)
ALL07125.1Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (577 aa)
ALL07134.1Hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
ALL07140.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
ALL07212.1Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
ALL07326.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (472 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (254 aa)
ALL07557.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
ALL07636.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (807 aa)
ALL07638.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ALL07741.1Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
gpmI2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (506 aa)
ALL08022.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
ALL08025.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
ALL08026.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
ALL08158.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
ALL08224.1Ribose-phosphate pyrophosphokinase; Catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (295 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (548 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (231 aa)
ALL08446.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (659 aa)
ALL08448.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
ALL08486.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (549 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
Your Current Organism:
Pedobacter sp. PACM27299
NCBI taxonomy Id: 1727164
Other names: P. sp. PACM 27299, Pedobacter sp. PACM 27299
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