STRINGSTRING
ALL04210.1 ALL04210.1 ALL04442.1 ALL04442.1 ALL04450.1 ALL04450.1 ALL04539.1 ALL04539.1 ALL04540.1 ALL04540.1 ALL04544.1 ALL04544.1 ALL04896.1 ALL04896.1 ALL04912.1 ALL04912.1 sdhA sdhA ALL04914.1 ALL04914.1 ALL04944.1 ALL04944.1 ALL05090.1 ALL05090.1 sucC sucC ALL05138.1 ALL05138.1 ALL05156.1 ALL05156.1 ALL05658.1 ALL05658.1 gltA gltA ALL08731.1 ALL08731.1 ALL05987.1 ALL05987.1 ALL06255.1 ALL06255.1 ALL06501.1 ALL06501.1 gltD gltD ALL07056.1 ALL07056.1 ALL08856.1 ALL08856.1 mqo mqo ALL07140.1 ALL07140.1 ALL07636.1 ALL07636.1 ALL07638.1 ALL07638.1 ALL08022.1 ALL08022.1 mdh mdh sucD sucD ALL08158.1 ALL08158.1 lipA lipA lipB lipB ALL08446.1 ALL08446.1 sdhA-2 sdhA-2 ALL08448.1 ALL08448.1 ALL08486.1 ALL08486.1 pdhA pdhA fumC fumC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALL04210.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (328 aa)
ALL04442.1Malic enzyme; NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (771 aa)
ALL04450.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
ALL04539.12-oxoglutarate dehydrogenase subunit E1; Derived by automated computational analysis using gene prediction method: Protein Homology. (930 aa)
ALL04540.12-oxoglutarate dehydrogenase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (406 aa)
ALL04544.1Catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
ALL04896.1Fumarylacetoacetate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ALL04912.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (638 aa)
ALL04914.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ALL04944.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (473 aa)
ALL05090.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (739 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
ALL05138.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
ALL05156.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (728 aa)
ALL05658.1Diapophytoene dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (428 aa)
ALL08731.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
ALL05987.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (446 aa)
ALL06255.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ALL06501.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1501 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
ALL07056.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (460 aa)
ALL08856.1Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (411 aa)
mqoMalate:quinone oxidoreductase; Malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
ALL07140.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
ALL07636.1Transketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (807 aa)
ALL07638.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ALL08022.12-hydroxyhepta-2,4-diene-1,7-dioate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
sucDsuccinate--CoA ligase; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
ALL08158.1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (758 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (295 aa)
lipBOctanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (231 aa)
ALL08446.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
sdhA-2Part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (659 aa)
ALL08448.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
ALL08486.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (549 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (331 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
Your Current Organism:
Pedobacter sp. PACM27299
NCBI taxonomy Id: 1727164
Other names: P. sp. PACM 27299, Pedobacter sp. PACM 27299
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