STRINGSTRING
pyrR pyrR FSZ17_09510 FSZ17_09510 pyrB pyrB pyrC pyrC carB carB pyrK pyrK pyrD pyrD pyrF pyrF pyrE pyrE FSZ17_10945 FSZ17_10945 allB allB FSZ17_04825 FSZ17_04825 guaD guaD FSZ17_03405 FSZ17_03405 FSZ17_03690 FSZ17_03690 FSZ17_12440 FSZ17_12440 guaC guaC FSZ17_12365 FSZ17_12365 FSZ17_12360 FSZ17_12360 FSZ17_18725 FSZ17_18725 tmk tmk tilS tilS hpt hpt deoD deoD FSZ17_14325 FSZ17_14325 thyA thyA fhs fhs FSZ17_14630 FSZ17_14630 xpt xpt FSZ17_15315 FSZ17_15315 FSZ17_15320 FSZ17_15320 deoB deoB FSZ17_15485 FSZ17_15485 folD folD purD purD purH purH purN purN purM purM purF purF purL purL purQ purQ purS purS purC purC purB purB purK purK purE purE guaB guaB tadA tadA FSZ17_16265 FSZ17_16265 deoC deoC FSZ17_16415 FSZ17_16415 udk udk purA purA FSZ17_22770 FSZ17_22770 tdk tdk glyA glyA upp upp FSZ17_21565 FSZ17_21565 folD-2 folD-2 FSZ17_20385 FSZ17_20385 FSZ17_20575 FSZ17_20575 FSZ17_08120 FSZ17_08120 FSZ17_07420 FSZ17_07420 FSZ17_07320 FSZ17_07320 mgtE-2 mgtE-2 purU purU
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrRUnannotated protein; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (190 aa)
FSZ17_09510Unannotated protein. (435 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (312 aa)
pyrCUnannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (428 aa)
carBUnannotated protein; Belongs to the CarB family. (1070 aa)
pyrKUnannotated protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (259 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (303 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (212 aa)
FSZ17_10945Unannotated protein. (442 aa)
allBUnannotated protein. (488 aa)
FSZ17_04825Unannotated protein. (440 aa)
guaDUnannotated protein; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (455 aa)
FSZ17_03405Unannotated protein. (590 aa)
FSZ17_03690Unannotated protein. (441 aa)
FSZ17_12440Unannotated protein. (152 aa)
guaCUnannotated protein; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
FSZ17_12365Unannotated protein. (444 aa)
FSZ17_12360Unannotated protein. (324 aa)
FSZ17_18725Unannotated protein. (426 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
tilSUnannotated protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (467 aa)
hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (181 aa)
deoDUnannotated protein. (234 aa)
FSZ17_14325Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (161 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
fhsUnannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (562 aa)
FSZ17_14630Unannotated protein. (435 aa)
xptUnannotated protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (198 aa)
FSZ17_15315Unannotated protein. (434 aa)
FSZ17_15320Unannotated protein; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa)
deoBUnannotated protein; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (394 aa)
FSZ17_15485Unannotated protein. (1247 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
purDUnannotated protein; Belongs to the GARS family. (424 aa)
purHUnannotated protein. (511 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (188 aa)
purMUnannotated protein. (341 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (471 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (738 aa)
purQUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (228 aa)
purSUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (84 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (241 aa)
purBUnannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (384 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (487 aa)
tadAUnannotated protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (177 aa)
FSZ17_16265Unannotated protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (132 aa)
deoCUnannotated protein; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (223 aa)
FSZ17_16415Unannotated protein. (143 aa)
udkUnannotated protein. (211 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
FSZ17_22770Unannotated protein. (802 aa)
tdkUnannotated protein. (205 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
FSZ17_21565Unannotated protein; Belongs to the 5'-nucleotidase family. (625 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
FSZ17_20385Unannotated protein. (234 aa)
FSZ17_20575Unannotated protein; Belongs to the 5'-nucleotidase family. (597 aa)
FSZ17_08120Unannotated protein. (149 aa)
FSZ17_07420Unannotated protein. (431 aa)
FSZ17_07320Unannotated protein. (613 aa)
mgtE-2Unannotated protein; Acts as a magnesium transporter. (452 aa)
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
Your Current Organism:
Bacillus sp. FJAT25496
NCBI taxonomy Id: 1742359
Other names: B. sp. FJAT-25496, Bacillus sp. FJAT-25496
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