STRINGSTRING
pckA pckA FSZ17_17895 FSZ17_17895 FSZ17_17880 FSZ17_17880 acsA acsA FSZ17_17660 FSZ17_17660 ackA ackA FSZ17_17485 FSZ17_17485 accD accD accA accA pfkA pfkA pyk pyk citZ citZ FSZ17_17435 FSZ17_17435 mdh mdh FSZ17_17425 FSZ17_17425 FSZ17_17380 FSZ17_17380 FSZ17_17150 FSZ17_17150 sdhA sdhA FSZ17_10730 FSZ17_10730 lpdA-2 lpdA-2 FSZ17_10775 FSZ17_10775 acnA acnA FSZ17_11010 FSZ17_11010 FSZ17_11425 FSZ17_11425 FSZ17_11770 FSZ17_11770 odhB odhB sucA sucA FSZ17_05130 FSZ17_05130 FSZ17_04890 FSZ17_04890 FSZ17_04875 FSZ17_04875 FSZ17_01250 FSZ17_01250 FSZ17_01645 FSZ17_01645 fdhA fdhA FSZ17_01795 FSZ17_01795 FSZ17_03635 FSZ17_03635 cysE cysE pdhA pdhA FSZ17_09010 FSZ17_09010 FSZ17_09015 FSZ17_09015 lpdA lpdA pyc pyc FSZ17_09295 FSZ17_09295 FSZ17_09310 FSZ17_09310 sdhB sdhB FSZ17_17110 FSZ17_17110 gcvT gcvT gcvPA gcvPA gcvPB gcvPB accB accB accC accC folD folD lpdA-3 lpdA-3 FSZ17_15600 FSZ17_15600 scpA-2 scpA-2 mce mce FSZ17_15550 FSZ17_15550 gndA gndA zwf zwf FSZ17_15515 FSZ17_15515 FSZ17_15400 FSZ17_15400 FSZ17_15140 FSZ17_15140 fhs fhs ilvA ilvA FSZ17_14260 FSZ17_14260 glcB glcB FSZ17_13590 FSZ17_13590 FSZ17_13200 FSZ17_13200 cysK cysK FSZ17_00355 FSZ17_00355 prs prs pgi pgi fdrA fdrA FSZ17_18750 FSZ17_18750 arcC arcC GCA_001439625_01489 GCA_001439625_01489 GCA_001439625_01488 GCA_001439625_01488 FSZ17_12505 FSZ17_12505 FSZ17_20835 FSZ17_20835 eno eno gpmI gpmI tpiA tpiA pgk pgk gap gap FSZ17_10725 FSZ17_10725 pdhA-2 pdhA-2 FSZ17_10680 FSZ17_10680 FSZ17_10675 FSZ17_10675 sdaAA sdaAA sdaAB sdaAB tkt tkt FSZ17_10285 FSZ17_10285 FSZ17_10280 FSZ17_10280 sucD sucD sucC sucC FSZ17_09630 FSZ17_09630 FSZ17_09320 FSZ17_09320 FSZ17_09315 FSZ17_09315 FSZ17_03215 FSZ17_03215 FSZ17_03825 FSZ17_03825 aceA aceA FSZ17_04230 FSZ17_04230 FSZ17_04255 FSZ17_04255 FSZ17_04570 FSZ17_04570 FSZ17_02405 FSZ17_02405 FSZ17_02800 FSZ17_02800 FSZ17_02890 FSZ17_02890 FSZ17_05790 FSZ17_05790 FSZ17_03095 FSZ17_03095 FSZ17_06175 FSZ17_06175 cysE-2 cysE-2 fumC fumC serC serC spxA spxA FSZ17_08720 FSZ17_08720 FSZ17_08725 FSZ17_08725 FSZ17_20655 FSZ17_20655 FSZ17_20490 FSZ17_20490 GCA_001439625_03604 GCA_001439625_03604 GCA_001439625_03603 GCA_001439625_03603 FSZ17_20355 FSZ17_20355 FSZ17_20350 FSZ17_20350 FSZ17_20345 FSZ17_20345 FSZ17_20155 FSZ17_20155 FSZ17_20150 FSZ17_20150 folD-2 folD-2 FSZ17_19380 FSZ17_19380 FSZ17_19365 FSZ17_19365 gcvH gcvH yugI yugI glyA glyA rpiB rpiB glpX glpX fsa fsa icmF icmF FSZ17_22135 FSZ17_22135 FSZ17_22145 FSZ17_22145 FSZ17_22150 FSZ17_22150 pta pta FSZ17_22295 FSZ17_22295 FSZ17_22300 FSZ17_22300 fdnG fdnG GCA_001439625_03045 GCA_001439625_03045 FSZ17_22525 FSZ17_22525 FSZ17_22660 FSZ17_22660 FSZ17_22820 FSZ17_22820 sucD-2 sucD-2 sucC-2 sucC-2 odhB-2 odhB-2 odhA odhA lpdA-4 lpdA-4 mqo mqo FSZ17_18310 FSZ17_18310
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pckAUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (528 aa)
FSZ17_17895Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (268 aa)
FSZ17_17880Unannotated protein. (280 aa)
acsAUnannotated protein. (572 aa)
FSZ17_17660Unannotated protein. (527 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (395 aa)
FSZ17_17485Unannotated protein. (412 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (325 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (586 aa)
citZUnannotated protein; Belongs to the citrate synthase family. (372 aa)
FSZ17_17435Unannotated protein. (422 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (312 aa)
FSZ17_17425Unannotated protein. (158 aa)
FSZ17_17380Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (343 aa)
FSZ17_17150Unannotated protein. (202 aa)
sdhAUnannotated protein. (583 aa)
FSZ17_10730Unannotated protein. (388 aa)
lpdA-2Unannotated protein. (476 aa)
FSZ17_10775Unannotated protein; Belongs to the catalase family. (485 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (902 aa)
FSZ17_11010Unannotated protein. (207 aa)
FSZ17_11425Unannotated protein. (319 aa)
FSZ17_11770Unannotated protein; Belongs to the pyruvate kinase family. (485 aa)
odhBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (413 aa)
sucAUnannotated protein; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (947 aa)
FSZ17_05130Unannotated protein. (355 aa)
FSZ17_04890Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (509 aa)
FSZ17_04875Unannotated protein. (515 aa)
FSZ17_01250Unannotated protein. (306 aa)
FSZ17_01645Unannotated protein. (343 aa)
fdhAUnannotated protein. (404 aa)
FSZ17_01795Unannotated protein. (300 aa)
FSZ17_03635Unannotated protein; Belongs to the PEP-utilizing enzyme family. (889 aa)
cysEUnannotated protein. (222 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (371 aa)
FSZ17_09010Unannotated protein. (325 aa)
FSZ17_09015Unannotated protein. (433 aa)
lpdAUnannotated protein. (469 aa)
pycUnannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1146 aa)
FSZ17_09295Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (252 aa)
FSZ17_09310Unannotated protein. (447 aa)
sdhBUnannotated protein. (254 aa)
FSZ17_17110Unannotated protein. (358 aa)
gcvTUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
gcvPAUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (449 aa)
gcvPBUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (486 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (166 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
lpdA-3Unannotated protein. (473 aa)
FSZ17_15600Unannotated protein. (608 aa)
scpA-2Unannotated protein. (731 aa)
mceUnannotated protein. (137 aa)
FSZ17_15550Unannotated protein. (516 aa)
gndAUnannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (470 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (500 aa)
FSZ17_15515Unannotated protein. (121 aa)
FSZ17_15400Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
FSZ17_15140Unannotated protein. (352 aa)
fhsUnannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (562 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (422 aa)
FSZ17_14260Unannotated protein. (331 aa)
glcBUnannotated protein; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
FSZ17_13590Unannotated protein; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (522 aa)
FSZ17_13200Unannotated protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (220 aa)
cysKUnannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (309 aa)
FSZ17_00355Unannotated protein. (155 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (318 aa)
pgiUnannotated protein; Belongs to the GPI family. (449 aa)
fdrAUnannotated protein. (515 aa)
FSZ17_18750Unannotated protein. (475 aa)
arcCUnannotated protein; Belongs to the carbamate kinase family. (316 aa)
GCA_001439625_01489Unannotated protein. (305 aa)
GCA_001439625_01488Unannotated protein. (66 aa)
FSZ17_12505Unannotated protein. (175 aa)
FSZ17_20835Unannotated protein. (138 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (511 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (394 aa)
gapUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
FSZ17_10725Unannotated protein. (331 aa)
pdhA-2Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (356 aa)
FSZ17_10680Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (409 aa)
FSZ17_10675Unannotated protein. (285 aa)
sdaAAUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (292 aa)
sdaABUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (220 aa)
tktUnannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
FSZ17_10285Unannotated protein. (288 aa)
FSZ17_10280Unannotated protein. (578 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
FSZ17_09630Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa)
FSZ17_09320Unannotated protein. (513 aa)
FSZ17_09315Unannotated protein. (70 aa)
FSZ17_03215Unannotated protein. (93 aa)
FSZ17_03825Unannotated protein. (131 aa)
aceAUnannotated protein. (428 aa)
FSZ17_04230Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
FSZ17_04255Unannotated protein. (77 aa)
FSZ17_04570Unannotated protein. (504 aa)
FSZ17_02405Unannotated protein. (407 aa)
FSZ17_02800Unannotated protein. (187 aa)
FSZ17_02890Unannotated protein. (306 aa)
FSZ17_05790Unannotated protein; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (515 aa)
FSZ17_03095Unannotated protein. (204 aa)
FSZ17_06175Unannotated protein. (290 aa)
cysE-2Unannotated protein. (221 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (457 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (358 aa)
spxAUnannotated protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
FSZ17_08720Unannotated protein. (337 aa)
FSZ17_08725Unannotated protein. (764 aa)
FSZ17_20655Unannotated protein. (463 aa)
FSZ17_20490Unannotated protein. (124 aa)
GCA_001439625_03604Unannotated protein. (281 aa)
GCA_001439625_03603Unannotated protein. (185 aa)
FSZ17_20355Unannotated protein. (569 aa)
FSZ17_20350Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (318 aa)
FSZ17_20345Unannotated protein. (294 aa)
FSZ17_20155Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (82 aa)
FSZ17_20150Unannotated protein. (451 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (283 aa)
FSZ17_19380Unannotated protein. (794 aa)
FSZ17_19365Unannotated protein; Belongs to the ArsC family. (119 aa)
gcvHUnannotated protein; Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate; Belongs to the GcvH family. (127 aa)
yugIUnannotated protein. (127 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (413 aa)
rpiBUnannotated protein. (146 aa)
glpXUnannotated protein. (320 aa)
fsaUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (214 aa)
icmFUnannotated protein; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1088 aa)
FSZ17_22135Unannotated protein. (379 aa)
FSZ17_22145Unannotated protein. (283 aa)
FSZ17_22150Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (395 aa)
ptaUnannotated protein. (325 aa)
FSZ17_22295Unannotated protein. (223 aa)
FSZ17_22300Unannotated protein. (272 aa)
fdnGUnannotated protein. (785 aa)
GCA_001439625_03045Unannotated protein. (188 aa)
FSZ17_22525Unannotated protein. (130 aa)
FSZ17_22660Unannotated protein. (284 aa)
FSZ17_22820Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (399 aa)
sucD-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucC-2Unannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa)
odhB-2Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (408 aa)
odhAUnannotated protein; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (942 aa)
lpdA-4Unannotated protein. (468 aa)
mqoUnannotated protein. (500 aa)
FSZ17_18310Unannotated protein. (123 aa)
Your Current Organism:
Bacillus sp. FJAT25496
NCBI taxonomy Id: 1742359
Other names: B. sp. FJAT-25496, Bacillus sp. FJAT-25496
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