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bioD bioD ANI98770.1 ANI98770.1 ANI98771.1 ANI98771.1 bioB bioB ANI98822.1 ANI98822.1 thiL thiL ANI98912.1 ANI98912.1 ANI98916.1 ANI98916.1 ANI98922.1 ANI98922.1 ANI99012.1 ANI99012.1 ANI99058.1 ANI99058.1 ANI99065.1 ANI99065.1 ANI99071.1 ANI99071.1 ANI99344.1 ANI99344.1 folD folD asd asd accD accD metZ metZ ANI99485.1 ANI99485.1 thiC thiC ANI99595.1 ANI99595.1 thiG thiG thiE thiE ANI99598.1 ANI99598.1 ANI99606.1 ANI99606.1 accA accA ANI99625.1 ANI99625.1 acsA acsA ANI99760.1 ANI99760.1 ANI99762.1 ANI99762.1 ANI99963.1 ANI99963.1 dxs dxs ANJ00188.1 ANJ00188.1 dxs-2 dxs-2 ANJ00438.1 ANJ00438.1 ANJ00836.1 ANJ00836.1 gshB gshB lipA lipA ANJ00559.1 ANJ00559.1 ANJ00578.1 ANJ00578.1 metK metK metXS metXS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (239 aa)
ANI98770.18-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
ANI98771.1Adenosylmethionine--8-amino-7-oxononanoate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (326 aa)
ANI98822.1acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (336 aa)
ANI98912.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
ANI98916.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (568 aa)
ANI98922.13-oxoadipate enol-lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
ANI99012.1Homoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
ANI99058.1Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (251 aa)
ANI99065.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
ANI99071.1Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
ANI99344.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (385 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (295 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (402 aa)
ANI99485.1propionate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (627 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (647 aa)
ANI99595.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (272 aa)
thiEThiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (308 aa)
ANI99598.1Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (294 aa)
ANI99606.15'-methylthioadenosine nucleosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (323 aa)
ANI99625.1Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (252 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (657 aa)
ANI99760.1Omega amino acid--pyruvate aminotransferase; Catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (450 aa)
ANI99762.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
ANI99963.1Cysteine synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (303 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (625 aa)
ANJ00188.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (633 aa)
ANJ00438.1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
ANJ00836.1Methyltransferase type 11; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
gshBGlutathione synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic GSH synthase family. (313 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa)
ANJ00559.1Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (916 aa)
ANJ00578.1Methylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (276 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (388 aa)
metXSHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (379 aa)
Your Current Organism:
Polynucleobacter wuianus
NCBI taxonomy Id: 1743168
Other names: CIP 111100, DSM 24008, P. wuianus, Polynucleobacter sp. QLW-P1FAT50C-4, Polynucleobacter wuianus Hahn et al. 2017, strain QLW-P1FAT50C-4
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