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hemA hemA hemL hemL Tel_02240 Tel_02240 Tel_02360 Tel_02360 hemC hemC Tel_16575 Tel_16575 hemF hemF hemH hemH Tel_06600 Tel_06600 Tel_07015 Tel_07015 Tel_08420 Tel_08420 Tel_08425 Tel_08425 Tel_09215 Tel_09215 cysG cysG Tel_10515 Tel_10515 Tel_13945 Tel_13945 hemE hemE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (420 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
Tel_02240Delta-aminolevulinic acid dehydratase; Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (322 aa)
Tel_02360Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (258 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (310 aa)
Tel_16575Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (306 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (368 aa)
Tel_06600Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
Tel_07015Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (383 aa)
Tel_08420Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
Tel_08425Squalene synthase HpnD; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
Tel_09215Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
cysGSirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (463 aa)
Tel_10515Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)
Tel_13945Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (354 aa)
Your Current Organism:
Tenderia electrophaga
NCBI taxonomy Id: 1748243
Other names: C. Tenderia electrophaga, Candidatus Tenderia electrophaga, Gammaproteobacteria bacterium NRL1
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