STRINGSTRING
Tel_00235 Tel_00235 gmk gmk Tel_00265 Tel_00265 Tel_01615 Tel_01615 Tel_01895 Tel_01895 Tel_01945 Tel_01945 Tel_01990 Tel_01990 purT purT Tel_02060 Tel_02060 Tel_02110 Tel_02110 purE purE purK purK adk adk Tel_02390 Tel_02390 purH purH apaH apaH purD purD Tel_03045 Tel_03045 Tel_03225 Tel_03225 Tel_03230 Tel_03230 Tel_03850 Tel_03850 purC purC purL purL Tel_04410 Tel_04410 ppnP ppnP purN purN purM purM Tel_04860 Tel_04860 Tel_04945 Tel_04945 nudF nudF Tel_05870 Tel_05870 Tel_05955 Tel_05955 Tel_06135 Tel_06135 surE surE purA purA Tel_07895 Tel_07895 Tel_08720 Tel_08720 Tel_08755 Tel_08755 cysC cysC Tel_10200 Tel_10200 cpdA cpdA guaA guaA guaB guaB ndk ndk Tel_12855 Tel_12855 purF purF Tel_13810 Tel_13810 Tel_14155 Tel_14155 prs prs Tel_15985 Tel_15985 sat sat
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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Tel_00235Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (216 aa)
Tel_00265(p)ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (727 aa)
Tel_01615Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (688 aa)
Tel_01895Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
Tel_01945Nucleoside triphosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (267 aa)
Tel_01990Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
purTPhosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (399 aa)
Tel_02060Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (740 aa)
Tel_02110Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GppA/Ppx family. (506 aa)
purEN5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (360 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (423 aa)
Tel_02390Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (959 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Involved in de novo purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
apaHDiadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (278 aa)
purDPhosphoribosylamine--glycine ligase; Catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (429 aa)
Tel_03045Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
Tel_03225Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
Tel_03230ADP-ribose diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
Tel_03850Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (466 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1299 aa)
Tel_04410Deoxyadenosine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (105 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (219 aa)
purMHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
Tel_04860Phosphoribosylpyrophosphate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribose-phosphate pyrophosphokinase family. (289 aa)
Tel_04945Phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (544 aa)
nudFADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
Tel_05870LOG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
Tel_05955Metallophosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
Tel_06135Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (489 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (433 aa)
Tel_07895Hypothetical protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (741 aa)
Tel_08720Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
Tel_08755Hypoxanthine-guanine phosphoribosyltransferase; Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. (202 aa)
Tel_10200Adenylosuccinate lyase; Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (455 aa)
cpdAHypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (267 aa)
guaAGMP synthetase; Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
Tel_12855Ribose-phosphate pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (503 aa)
Tel_13810Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
Tel_14155Deoxyguanosinetriphosphate triphosphohydrolase; dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
Tel_15985Ribonucleoside-diphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1094 aa)
satATP sulfurylase; ATPS; converts ATP and sulfate to 5'phosphosulfate and pyrophosphate; in some organisms this enzyme is involved in the incorporation of inorganic sulfate while in others it is involved in the production of ATP in the reverse direction; the enzyme from Thermus thermophilus is dimeric and binds a zinc ion that is coordinated by cysteine and histidine residues that are not found in all related proteins but is found in some thermophilic organisms; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
Your Current Organism:
Tenderia electrophaga
NCBI taxonomy Id: 1748243
Other names: C. Tenderia electrophaga, Candidatus Tenderia electrophaga, Gammaproteobacteria bacterium NRL1
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