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purU | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) | ||||
CEW89_08125 | Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (157 aa) | ||||
thyA | Unannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) | ||||
folD | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa) | ||||
CEW89_17315 | Unannotated protein; Belongs to the GcvT family. (377 aa) | ||||
purU-2 | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa) | ||||
folD-2 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa) | ||||
CEW89_17230 | Unannotated protein; Belongs to the GcvT family. (790 aa) | ||||
CEW89_08275 | Unannotated protein. (399 aa) | ||||
metF | Unannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (277 aa) | ||||
CEW89_14380 | Unannotated protein; Belongs to the folylpolyglutamate synthase family. (424 aa) | ||||
gcvP | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (948 aa) | ||||
gcvH | Unannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa) | ||||
gcvT | Unannotated protein. (379 aa) | ||||
glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) | ||||
hemA | Unannotated protein. (409 aa) | ||||
CEW89_15750 | Unannotated protein; Belongs to the GcvT family. (853 aa) | ||||
folD-3 | Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa) | ||||
purU-3 | Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa) | ||||
CEW89_15775 | Unannotated protein. (360 aa) | ||||
glyA-2 | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa) | ||||
CEW89_15815 | Unannotated protein. (184 aa) | ||||
CEW89_15820 | Unannotated protein; Belongs to the GcvT family. (997 aa) | ||||
CEW89_15825 | Unannotated protein. (100 aa) | ||||
CEW89_15830 | Unannotated protein. (417 aa) | ||||
CEW89_15840 | Unannotated protein; Belongs to the BCCT transporter (TC 2.A.15) family. (546 aa) | ||||
CEW89_15845 | Unannotated protein. (364 aa) | ||||
CEW89_15850 | Unannotated protein. (429 aa) |