STRINGSTRING
purU purU CEW89_08125 CEW89_08125 thyA thyA folD folD CEW89_17315 CEW89_17315 purU-2 purU-2 folD-2 folD-2 CEW89_17230 CEW89_17230 CEW89_08275 CEW89_08275 metF metF CEW89_14380 CEW89_14380 gcvP gcvP gcvH gcvH gcvT gcvT glyA glyA hemA hemA CEW89_15750 CEW89_15750 folD-3 folD-3 purU-3 purU-3 CEW89_15775 CEW89_15775 glyA-2 glyA-2 CEW89_15815 CEW89_15815 CEW89_15820 CEW89_15820 CEW89_15825 CEW89_15825 CEW89_15830 CEW89_15830 CEW89_15840 CEW89_15840 CEW89_15845 CEW89_15845 CEW89_15850 CEW89_15850
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
CEW89_08125Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (157 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
CEW89_17315Unannotated protein; Belongs to the GcvT family. (377 aa)
purU-2Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa)
CEW89_17230Unannotated protein; Belongs to the GcvT family. (790 aa)
CEW89_08275Unannotated protein. (399 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (277 aa)
CEW89_14380Unannotated protein; Belongs to the folylpolyglutamate synthase family. (424 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (948 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
gcvTUnannotated protein. (379 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
hemAUnannotated protein. (409 aa)
CEW89_15750Unannotated protein; Belongs to the GcvT family. (853 aa)
folD-3Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
purU-3Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
CEW89_15775Unannotated protein. (360 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
CEW89_15815Unannotated protein. (184 aa)
CEW89_15820Unannotated protein; Belongs to the GcvT family. (997 aa)
CEW89_15825Unannotated protein. (100 aa)
CEW89_15830Unannotated protein. (417 aa)
CEW89_15840Unannotated protein; Belongs to the BCCT transporter (TC 2.A.15) family. (546 aa)
CEW89_15845Unannotated protein. (364 aa)
CEW89_15850Unannotated protein. (429 aa)
Your Current Organism:
Celeribacter ethanolicus
NCBI taxonomy Id: 1758178
Other names: C. ethanolicus, CGMCC 1.15406, Celeribacter ethanolicus Jian et al. 2016, Celeribacter sp. NH195, JCM 31095, strain NH195
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.